Ctdsp1 CTD small phosphatase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctdsp1provided by MGI
Official Full Name: CTD small phosphatase 1provided by MGI
Primary source: MGI:MGI:2654470
See related: Ensembl:ENSMUSG00000026176 AllianceGenome:MGI:2654470
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GIP; Nif3; SCP1; NLIIF
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell differentiation; and negative regulation of protein phosphorylation. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and integumental system. Orthologous to human CTDSP1 (CTD small phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 92.4), lung adult (RPKM 83.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C3; 1 38.54 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (74430625..74436444)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (74391609..74397285)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Consistently, the authors observed increased AKT phosphorylation and angiogenesis followed by enhanced tumorigenesis in Ctdsp1 (which encodes SCP1) gene - knockout mice. Importantly, they discovered that the membrane localization of SCP1 is crucial for impeding angiogenesis and tumor growth, and this localization depends on palmitoylation of a conserved cysteine motif within its NH2 terminus.
Title: Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis.
Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP.
Title: Regulatory effect of the glial Golli-BG21 protein on the full-length murine small C-terminal domain phosphatase (SCP1, or Golli-interacting protein).
Findings suggest that SCP1 may inhibit the osteoblastic differentiation induced by the BMP-Smad axis via Runx2 by suppressing downstream effector(s).
Title: Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase.
Expression and purification of the active variant of recombinant murine Golli-interacting protein (GIP) and its characterization
Title: Expression and purification of the active variant of recombinant murine Golli-interacting protein (GIP)--characterization of its phosphatase activity and interaction with Golli-BG21.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Names: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; NLI-interacting factor 3; golli-interacting protein; nuclear LIM interactor-interacting factor 3; small C-terminal domain phosphatase 1; small CTD phosphatase 1

NP_001408190.1

EC 3.1.3.16

NP_001408191.1

EC 3.1.3.16

NP_001408192.1

EC 3.1.3.16

NP_694728.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421261.1 → NP_001408190.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC098570
NM_001421262.1 → NP_001408191.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC098570
NM_001421263.1 → NP_001408192.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC098570
NM_153088.3 → NP_694728.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2

See identical proteins and their annotated locations for NP_694728.1

Status: VALIDATED

Source sequence(s)

AC098570

Consensus CDS

CCDS15048.1

UniProtKB/Swiss-Prot

P58466

UniProtKB/TrEMBL

Q5I0X8

Related

ENSMUSP00000027367.8, ENSMUST00000027367.14

Conserved Domains (1) summary

TIGR02251
Location:90 → 249

HIF-SF_euk; Dullard-like phosphatase domain