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    Zfp62 zinc finger protein 62 [ Mus musculus (house mouse) ]

    Gene ID: 22720, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp62provided by MGI
    Official Full Name
    zinc finger protein 62provided by MGI
    Primary source
    MGI:MGI:99662
    See related
    Ensembl:ENSMUSG00000046311 AllianceGenome:MGI:99662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; heart; limb; limb bud; and urinary system. Orthologous to human ZFP62 (ZFP62 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.2), CNS E14 (RPKM 4.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B1.2; 11 29.23 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49093556..49109643)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49203261..49218816)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily O member 1 Neighboring gene butyrophilin-like 9 Neighboring gene STARR-seq mESC enhancer starr_29371 Neighboring gene STARR-seq mESC enhancer starr_29372 Neighboring gene predicted gene, 18583 Neighboring gene STARR-positive B cell enhancer ABC_E6976 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49057557-49057744 Neighboring gene predicted gene, 51893 Neighboring gene STARR-positive B cell enhancer ABC_E195 Neighboring gene mannoside acetylglucosaminyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differentiation dependent expression in muscle cells of ZT3, a novel zinc finger factor differentially expressed in embryonic and adult tissues. Polimeni M, et al. Mech Dev, 1996 Jan. PMID 8808410
    2. Genetic mapping of mouse heat shock protein genes Hsc4a to chromosome 11 and Hsc74 to chromosome 18 and two Hsc74 pseudogenes to chromosomes X and 8. Hunt CR, et al. Genomics, 1999 Mar 15. PMID 10087208
    3. Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens. Danciger M, et al. Genomics, 1995 Jul 1. PMID 7590745
    4. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    5. A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Choi MY, et al. Development, 2006 Oct. PMID 16971476

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 62
    Names
    ZT3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024846.2 → NP_001020017.1  zinc finger protein 62 isoform 2

      See identical proteins and their annotated locations for NP_001020017.1

      Status: VALIDATED

      Source sequence(s)
      AK028351, AK048619, AL606829, BC065692, BE635021
      Consensus CDS
      CCDS24601.1
      UniProtKB/Swiss-Prot
      Q8C827
      Related
      ENSMUSP00000104820.2, ENSMUST00000109197.8
      Conserved Domains (3) summary
      COG5048
      Location:430 → 843
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:372 → 451
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001362725.1 → NP_001349654.1  zinc finger protein 62 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606829, BE635021
      UniProtKB/Swiss-Prot
      Q3U3H0, Q62510, Q8BT00, Q8C2S6, Q8C827, Q8R5D1
      Conserved Domains (3) summary
      COG5048
      Location:437 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:379 → 458
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001362726.1 → NP_001349655.1  zinc finger protein 62 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606829, BE635021
      UniProtKB/Swiss-Prot
      Q3U3H0, Q62510, Q8BT00, Q8C2S6, Q8C827, Q8R5D1
      Conserved Domains (3) summary
      COG5048
      Location:437 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:379 → 458
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001362727.1 → NP_001349656.1  zinc finger protein 62 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606829, BE635021
      UniProtKB/Swiss-Prot
      Q3U3H0, Q62510, Q8BT00, Q8C2S6, Q8C827, Q8R5D1
      Conserved Domains (3) summary
      COG5048
      Location:437 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:379 → 458
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001362728.1 → NP_001349657.1  zinc finger protein 62 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606829, BE635021
      Consensus CDS
      CCDS24601.1
      Conserved Domains (3) summary
      COG5048
      Location:430 → 843
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:372 → 451
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001362729.1 → NP_001349658.1  zinc finger protein 62 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606829, BE635021
      Consensus CDS
      CCDS24601.1
      Related
      ENSMUSP00000104821.2, ENSMUST00000109198.8
      Conserved Domains (3) summary
      COG5048
      Location:430 → 843
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:372 → 451
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001362730.1 → NP_001349659.1  zinc finger protein 62 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606829, BE635021
      Consensus CDS
      CCDS24601.1
      Conserved Domains (3) summary
      COG5048
      Location:430 → 843
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:372 → 451
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001362731.1 → NP_001349660.1  zinc finger protein 62 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK147890, AL606829, BE635021
      Consensus CDS
      CCDS24601.1
      Related
      ENSMUSP00000116045.2, ENSMUST00000136539.2
      Conserved Domains (3) summary
      COG5048
      Location:430 → 843
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:372 → 451
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001425606.1 → NP_001412535.1  zinc finger protein 62 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606829
      UniProtKB/Swiss-Prot
      Q3U3H0, Q62510, Q8BT00, Q8C2S6, Q8C827, Q8R5D1

    10. NM_001425607.1 → NP_001412536.1  zinc finger protein 62 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606829
      UniProtKB/Swiss-Prot
      Q3U3H0, Q62510, Q8BT00, Q8C2S6, Q8C827, Q8R5D1

    11. NM_001425608.1 → NP_001412537.1  zinc finger protein 62 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606829
      UniProtKB/Swiss-Prot
      Q3U3H0, Q62510, Q8BT00, Q8C2S6, Q8C827, Q8R5D1

    12. NM_001425610.1 → NP_001412539.1  zinc finger protein 62 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606829

    13. NM_001425611.1 → NP_001412540.1  zinc finger protein 62 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606829

    14. NM_001425612.1 → NP_001412541.1  zinc finger protein 62 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606829

    15. NM_001425613.1 → NP_001412542.1  zinc finger protein 62 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606829

    16. NM_009562.4 → NP_033588.2  zinc finger protein 62 isoform 1

      See identical proteins and their annotated locations for NP_033588.2

      Status: VALIDATED

      Source sequence(s)
      AL606829
      UniProtKB/Swiss-Prot
      Q3U3H0, Q62510, Q8BT00, Q8C2S6, Q8C827, Q8R5D1
      Conserved Domains (3) summary
      COG5048
      Location:437 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:379 → 458
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      49093556..49109643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245950.2 → XP_030101810.1  zinc finger protein 62 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:430 → 843
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:372 → 451
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036156643.1 → XP_036012536.1  zinc finger protein 62 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3H0, Q62510, Q8BT00, Q8C2S6, Q8C827, Q8R5D1
      Conserved Domains (3) summary
      COG5048
      Location:437 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:379 → 458
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030245946.2 → XP_030101806.1  zinc finger protein 62 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3H0, Q62510, Q8BT00, Q8C2S6, Q8C827, Q8R5D1
      Conserved Domains (3) summary
      COG5048
      Location:437 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:379 → 458
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_036156648.1 → XP_036012541.1  zinc finger protein 62 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:430 → 843
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:372 → 451
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036156647.1 → XP_036012540.1  zinc finger protein 62 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:430 → 843
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:372 → 451
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_036156644.1 → XP_036012537.1  zinc finger protein 62 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3H0, Q62510, Q8BT00, Q8C2S6, Q8C827, Q8R5D1
      Conserved Domains (3) summary
      COG5048
      Location:437 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:379 → 458
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_030245947.2 → XP_030101807.1  zinc finger protein 62 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:430 → 843
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:372 → 451
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_036156646.1 → XP_036012539.1  zinc finger protein 62 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3H0, Q62510, Q8BT00, Q8C2S6, Q8C827, Q8R5D1
      Conserved Domains (3) summary
      COG5048
      Location:437 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:379 → 458
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C827.1 GenPept UniProtKB/Swiss-Prot:Q8C827

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