Ormdl1 ORM1-like 1 (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ormdl1provided by MGI
Official Full Name: ORM1-like 1 (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:2181669
See related: Ensembl:ENSMUSG00000026097 AllianceGenome:MGI:2181669
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C730042F17Rik
Summary: Predicted to be involved in cellular sphingolipid homeostasis; ceramide metabolic process; and negative regulation of ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of SPOTS complex. Orthologous to human ORMDL1 (ORMDL sphingolipid biosynthesis regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 14.5), placenta adult (RPKM 13.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.1; 1 26.99 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (53336254..53349404)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (53297095..53310245)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we found that Ormdl1 and Ormdl3 function redundantly to suppress the levels of bioactive sphingolipid metabolites during myelination of the sciatic nerve
Title: The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice.
free-cholesterol accumulation diminishes ORMDL1 expression
Title: ORMDL orosomucoid-like proteins are degraded by free-cholesterol-loading-induced autophagy.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular sphingolipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of motor behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of myelination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of regulation of ceramide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of regulation of sphingolipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of sphingomyelin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of SPOTS complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ORM1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.