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    Zfp52 zinc finger protein 52 [ Mus musculus (house mouse) ]

    Gene ID: 22710, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp52provided by MGI
    Official Full Name
    zinc finger protein 52provided by MGI
    Primary source
    MGI:MGI:99199
    See related
    Ensembl:ENSMUSG00000051341 AllianceGenome:MGI:99199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp76; KRAB11; Zfp-52; mszf24; mszf34; mszf75; zfec29; mszf23-2
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; and spinal cord. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 1.0), CNS E18 (RPKM 0.8) and 26 other tissues See more
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    Genomic context

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    Location:
    17 A3.2; 17 11.4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21755801..21783624)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21533725..21563362)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42008 Neighboring gene STARR-seq mESC enhancer starr_42009 Neighboring gene predicted gene, 52290 Neighboring gene STARR-positive B cell enhancer ABC_E3186 Neighboring gene zinc finger protein 53 Neighboring gene RIKEN cDNA 9330136K24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:21669090-21669243 Neighboring gene STARR-positive B cell enhancer ABC_E9942 Neighboring gene zinc finger protein 948 Neighboring gene predicted gene, 30531 Neighboring gene predicted gene, 41541

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A cluster of related zinc finger protein genes is deleted in the mouse embryonic lethal mutation tw18. Crossley PH, et al. Proc Natl Acad Sci U S A, 1991 Sep 15. PMID 1680234, Free PMC Article
    2. Physical analysis of the region deleted in the tw18 allele of the mouse tcl-4 complementation group. Barclay J, et al. Genomics, 1996 Aug 15. PMID 8812414
    3. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    4. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    5. Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice. Okada A, et al. Birth Defects Res A Clin Mol Teratol, 2005 Apr. PMID 15799026

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 52
    Names
    KRAB-zinc finger protein 76

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144515.2 → NP_653098.2  zinc finger protein 52

      See identical proteins and their annotated locations for NP_653098.2

      Status: VALIDATED

      Source sequence(s)
      AK032299, BY206348
      Consensus CDS
      CCDS37464.1
      UniProtKB/TrEMBL
      Q8BJ45
      Related
      ENSMUSP00000156662.2, ENSMUST00000233281.2
      Conserved Domains (5) summary
      COG5048
      Location:184 → 615
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:440 → 460
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box
      pfam13465
      Location:648 → 673
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:690 → 714
      zf-H2C2_5; C2H2-type zinc-finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      21755801..21783624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160580.1 → XP_036016473.1  zinc finger protein 52 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:147 → 578
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:403 → 423
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:611 → 636
      zf-H2C2_2; Zinc-finger double domain

    2. XM_036160581.1 → XP_036016474.1  zinc finger protein 52 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:105 → 536
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:361 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:569 → 594
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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