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    Zfp46 zinc finger protein 46 [ Mus musculus (house mouse) ]

    Gene ID: 22704, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp46provided by MGI
    Official Full Name
    zinc finger protein 46provided by MGI
    Primary source
    MGI:MGI:99192
    See related
    Ensembl:ENSMUSG00000051351 AllianceGenome:MGI:99192
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mlz-4; Zfp-46; Znf436
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Is expressed in ganglia; genitourinary system; and hindbrain. Orthologous to human ZNF436 (zinc finger protein 436). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 13.1), whole brain E14.5 (RPKM 12.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D3; 4 68.34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136011479..136021163)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136284168..136293942)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11749 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene STARR-seq mESC enhancer starr_11750 Neighboring gene transcription elongation factor A (SII), 3 Neighboring gene STARR-positive B cell enhancer ABC_E9604 Neighboring gene STARR-positive B cell enhancer ABC_E4689 Neighboring gene STARR-seq mESC enhancer starr_11754 Neighboring gene STARR-seq mESC enhancer starr_11755 Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene predicted gene, 54262 Neighboring gene predicted gene, 31295

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel zinc-finger protein-encoding cDNA from the mouse eye lens. Brady JP, et al. Gene, 1993 Feb 28. PMID 8444344
    2. Mapping of two zinc finger protein genes to mouse chromosomes 4 and 7. Denny P, et al. Mamm Genome, 1995 Sep. PMID 8535085
    3. A mechanism misregulating p27 in tumors discovered in a functional genomic screen. Garrett-Engele CM, et al. PLoS Genet, 2007 Dec. PMID 18069898, Free PMC Article
    4. G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. Zhang D, et al. J Biol Chem, 2008 Mar 28. PMID 18218630, Free PMC Article
    5. Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens. Danciger M, et al. Genomics, 1995 Jul 1. PMID 7590745

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 436
    Names
    zinc finger protein MLZ-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356308.2 → NP_001343237.1  zinc finger protein 436 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL935264
      Consensus CDS
      CCDS18804.1
      UniProtKB/Swiss-Prot
      Q03309, Q69ZC6, Q8BPP0, Q8BQC2
      Conserved Domains (3) summary
      smart00349
      Location:1 → 64
      KRAB; krueppel associated box
      COG5048
      Location:145 → 452
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:178 → 198
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001370651.2 → NP_001357580.1  zinc finger protein 436 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL935264
      Conserved Domains (3) summary
      COG5048
      Location:163 → 470
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:196 → 216
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:13 → 54
      KRAB; KRAB box

    3. NM_001425037.1 → NP_001411966.1  zinc finger protein 436 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL935264

    4. NM_001425038.1 → NP_001411967.1  zinc finger protein 436 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL935264
      UniProtKB/Swiss-Prot
      Q03309, Q69ZC6, Q8BPP0, Q8BQC2

    5. NM_009557.5 → NP_033583.2  zinc finger protein 436 isoform 1

      See identical proteins and their annotated locations for NP_033583.2

      Status: VALIDATED

      Source sequence(s)
      AL935264
      Consensus CDS
      CCDS18804.1
      UniProtKB/Swiss-Prot
      Q03309, Q69ZC6, Q8BPP0, Q8BQC2
      Related
      ENSMUSP00000070216.5, ENSMUST00000069195.5
      Conserved Domains (3) summary
      smart00349
      Location:1 → 64
      KRAB; krueppel associated box
      COG5048
      Location:145 → 452
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:178 → 198
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      136011479..136021163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163984.1 → XP_036019877.1  zinc finger protein 436 isoform X2

      UniProtKB/Swiss-Prot
      Q03309, Q69ZC6, Q8BPP0, Q8BQC2
      Conserved Domains (3) summary
      smart00349
      Location:1 → 64
      KRAB; krueppel associated box
      COG5048
      Location:145 → 452
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:178 → 198
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006538728.1 → XP_006538791.1  zinc finger protein 436 isoform X1

      See identical proteins and their annotated locations for XP_006538791.1

      Conserved Domains (3) summary
      COG5048
      Location:163 → 470
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:196 → 216
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:13 → 54
      KRAB; KRAB box
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BPP0.1 GenPept UniProtKB/Swiss-Prot:Q8BPP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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