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    Zfp41 zinc finger protein 41 [ Mus musculus (house mouse) ]

    Gene ID: 22701, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp41provided by MGI
    Official Full Name
    zinc finger protein 41provided by MGI
    Primary source
    MGI:MGI:99186
    See related
    Ensembl:ENSMUSG00000047003 AllianceGenome:MGI:99186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp-41; CTfin92
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human ZFP41 (ZFP41 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 18.9), CNS E11.5 (RPKM 18.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D3; 15 34.62 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75486972..75501676)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75615200..75627448)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member H Neighboring gene GPI-anchored HDL-binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1174 Neighboring gene STARR-seq mESC enhancer starr_39016 Neighboring gene predicted gene, 46519 Neighboring gene predicted gene, 38506

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of a mouse zinc finger protein gene in both spermatocytes and oocytes during meiosis. Noce T, et al. Dev Biol, 1992 Oct. PMID 1397691
    2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044718.3 → NP_001038183.1  zinc finger protein 41

      See identical proteins and their annotated locations for NP_001038183.1

      Status: VALIDATED

      Source sequence(s)
      AC119264
      Consensus CDS
      CCDS37108.1
      UniProtKB/Swiss-Prot
      Q02526, Q8BSV7
      Related
      ENSMUSP00000124626.2, ENSMUST00000161785.8
      Conserved Domains (2) summary
      COG5189
      Location:111 → 191
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:117 → 137
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001416214.1 → NP_001403143.1  zinc finger protein 41

      Status: VALIDATED

      Source sequence(s)
      AC119264
      UniProtKB/Swiss-Prot
      Q02526, Q8BSV7

    3. NM_001416215.1 → NP_001403144.1  zinc finger protein 41

      Status: VALIDATED

      Source sequence(s)
      AC119264
      UniProtKB/Swiss-Prot
      Q02526, Q8BSV7

    4. NM_001416216.1 → NP_001403145.1  zinc finger protein 41

      Status: VALIDATED

      Source sequence(s)
      AC119264
      UniProtKB/Swiss-Prot
      Q02526, Q8BSV7

    5. NM_001416217.1 → NP_001403146.1  zinc finger protein 41

      Status: VALIDATED

      Source sequence(s)
      AC119264
      UniProtKB/Swiss-Prot
      Q02526, Q8BSV7

    6. NM_011759.4 → NP_035889.1  zinc finger protein 41

      See identical proteins and their annotated locations for NP_035889.1

      Status: VALIDATED

      Source sequence(s)
      AC119264
      Consensus CDS
      CCDS37108.1
      UniProtKB/Swiss-Prot
      Q02526, Q8BSV7
      Related
      ENSMUSP00000056510.8, ENSMUST00000054555.10
      Conserved Domains (2) summary
      COG5189
      Location:111 → 191
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:117 → 137
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_183609.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC119264

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75486972..75501676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02526.2 GenPept UniProtKB/Swiss-Prot:Q02526

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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