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    Zscan21 zinc finger and SCAN domain containing 21 [ Mus musculus (house mouse) ]

    Gene ID: 22697, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zscan21provided by MGI
    Official Full Name
    zinc finger and SCAN domain containing 21provided by MGI
    Primary source
    MGI:MGI:99182
    See related
    Ensembl:ENSMUSG00000037017 AllianceGenome:MGI:99182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RU49; Zfp38; Zfp-38; Zipro1; CTfin51
    Summary
    Enables DNA binding activity. Involved in male meiosis I and spermatogenesis. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut gland; liver and biliary system; and nervous system. Orthologous to human ZSCAN21 (zinc finger and SCAN domain containing 21). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 21.4), CNS E14 (RPKM 21.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zscan21 in Genome Data Viewer
    Location:
    5 G2; 5 76.96 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138115161..138132527)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138116899..138134265)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sperm motility kinase 3C Neighboring gene zinc finger with KRAB and SCAN domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E8086 Neighboring gene zinc finger protein 113 Neighboring gene STARR-positive B cell enhancer ABC_E4799 Neighboring gene STARR-positive B cell enhancer ABC_E9656 Neighboring gene COP9 signalosome subunit 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcription factor ZFP38 is essential for meiosis prophase I in male mice. Yan Z, et al. Reproduction, 2016 Nov. PMID 27492080
    2. BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin. Yang XW, et al. Nat Genet, 1999 Aug. PMID 10431235
    3. Gene dosage in mice--BAC to the future. Magdaleno SM, et al. Nat Genet, 1999 Aug. PMID 10431229
    4. Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49. Yang XW, et al. Development, 1996 Feb. PMID 8625807
    5. A novel murine zinc finger gene mapped within the tw18 deletion region expresses in germ cells and embryonic nervous system. Noce T, et al. Dev Biol, 1993 Feb. PMID 8432396

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 21
    Names
    transcription factor RU49
    zinc finger proliferation 1
    zinc finger protein 38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044703.2 → NP_001038168.1  zinc finger and SCAN domain-containing protein 21

      See identical proteins and their annotated locations for NP_001038168.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1,2,3 and 4 encode the same protein.
      Source sequence(s)
      AI326272, AK146875, BY293243, BY309906, BY654936, DV651309
      Consensus CDS
      CCDS19790.1
      UniProtKB/Swiss-Prot
      Q07231, Q921V2
      Related
      ENSMUSP00000106585.3, ENSMUST00000110960.9
      Conserved Domains (4) summary
      smart00431
      Location:118 → 230
      SCAN; leucine rich region
      COG5048
      Location:339 → 535
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:472 → 492
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:528 → 548
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001044704.2 → NP_001038169.1  zinc finger and SCAN domain-containing protein 21

      See identical proteins and their annotated locations for NP_001038169.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1,2,3 and 4 encode the same protein.
      Source sequence(s)
      AI326272, AK146776, AK146875, BY293243, BY654936, CF915830, DV651309
      Consensus CDS
      CCDS19790.1
      UniProtKB/Swiss-Prot
      Q07231, Q921V2
      Related
      ENSMUSP00000053430.9, ENSMUST00000062350.15
      Conserved Domains (4) summary
      smart00431
      Location:118 → 230
      SCAN; leucine rich region
      COG5048
      Location:339 → 535
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:472 → 492
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:528 → 548
      zf-C2H2; Zinc finger, C2H2 type

    3. NM_001044705.2 → NP_001038170.1  zinc finger and SCAN domain-containing protein 21

      See identical proteins and their annotated locations for NP_001038170.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1,2,3 and 4 encode the same protein.
      Source sequence(s)
      AI326272, AK146875, BY293243, BY309906, BY654936, DV651309
      Consensus CDS
      CCDS19790.1
      UniProtKB/Swiss-Prot
      Q07231, Q921V2
      Related
      ENSMUSP00000079557.4, ENSMUST00000080732.10
      Conserved Domains (4) summary
      smart00431
      Location:118 → 230
      SCAN; leucine rich region
      COG5048
      Location:339 → 535
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:472 → 492
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:528 → 548
      zf-C2H2; Zinc finger, C2H2 type

    4. NM_011757.3 → NP_035887.2  zinc finger and SCAN domain-containing protein 21

      See identical proteins and their annotated locations for NP_035887.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1,2,3 and 4 encode the same protein.
      Source sequence(s)
      AI326272, AK146875, BY293243, BY654936, DV651309
      Consensus CDS
      CCDS19790.1
      UniProtKB/Swiss-Prot
      Q07231, Q921V2
      Related
      ENSMUSP00000106586.3, ENSMUST00000110961.9
      Conserved Domains (4) summary
      smart00431
      Location:118 → 230
      SCAN; leucine rich region
      COG5048
      Location:339 → 535
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:472 → 492
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:528 → 548
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138115161..138132527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240942.1 → XP_011239244.1  zinc finger and SCAN domain-containing protein 21 isoform X1

      See identical proteins and their annotated locations for XP_011239244.1

      UniProtKB/Swiss-Prot
      Q07231, Q921V2
      Conserved Domains (4) summary
      smart00431
      Location:118 → 230
      SCAN; leucine rich region
      COG5048
      Location:339 → 535
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:472 → 492
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:528 → 548
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07231.2 GenPept UniProtKB/Swiss-Prot:Q07231

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