Zpr1 ZPR1 zinc finger [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zpr1provided by MGI
Official Full Name: ZPR1 zinc fingerprovided by MGI
Primary source: MGI:MGI:1330262
See related: Ensembl:ENSMUSG00000032078 AllianceGenome:MGI:1330262
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp259; Znf259
Summary: Enables receptor tyrosine kinase binding activity; translation initiation factor binding activity; and zinc ion binding activity. Involved in several processes, including Cajal body organization; blastocyst growth; and nervous system development. Located in several cellular components, including growth cone; nuclear body; and perikaryon. Is expressed in several structures, including liver; lung; spleen; testis; and urinary system. Orthologous to human ZPR1 (ZPR1 zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 25.2), ovary adult (RPKM 14.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 25.38 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (46184362..46193941)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (46273064..46282643)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy.
Title: ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy.
these findings provide insight into the molecular basis of respiratory failure associated with SMA pathogenesis and identify ZPR1 and HoxA5 as potential targets that lay a foundation for developing therapeutic strategies to treat respiratory distress in SMA.
Title: Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy.
Data suggest that the severity of disease correlates negatively with ZPR1 levels and ZPR1 may be a protective modifier of spinal muscular atrophy (SMA).
Title: The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy.
the interaction of ZPR1 and eEF1alpha
Title: Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor 1alpha.
ZPR1 contributes to the regulation of survival motor neurons complexes and that it is essential for cell survival
Title: ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.
ZPR1-deficient mice exhibit axonal pathology and neurodegeneration
Title: Deficiency of the zinc finger protein ZPR1 causes neurodegeneration.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI303781 (e-PCR)
- UniSTS:179891

BB396022 (e-PCR)
- UniSTS:208371

AI046360 (e-PCR)
- UniSTS:208372

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Cajal body organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Cajal body organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in inner cell mass cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in pre-mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trophectodermal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Cajal body	IBA Inferred from Biological aspect of Ancestor more info
located_in Cajal body	IDA Inferred from Direct Assay more info	PubMed
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in Gemini of coiled bodies	IDA Inferred from Direct Assay more info	PubMed
located_in Gemini of coiled bodies	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein ZPR1

Names: zinc finger protein 259

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011752.2 → NP_035882.1 zinc finger protein ZPR1

See identical proteins and their annotated locations for NP_035882.1

Status: VALIDATED

Source sequence(s)

AC164105

Consensus CDS

CCDS23144.1

UniProtKB/Swiss-Prot

Q62384

UniProtKB/TrEMBL

Q3TY03, Q9JJA1

Related

ENSMUSP00000117725.2, ENSMUST00000156440.8

Conserved Domains (2) summary

smart00709
Location:257 → 416

Zpr1; Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins

pfam03367
Location:49 → 206

zf-ZPR1; ZPR1 zinc-finger domain