Flvcr1 feline leukemia virus subgroup C cellular receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Flvcr1provided by MGI
Official Full Name: feline leukemia virus subgroup C cellular receptor 1provided by MGI
Primary source: MGI:MGI:2444881
See related: Ensembl:ENSMUSG00000066595 AllianceGenome:MGI:2444881
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FLVCR; Mfsd7b; 9630055N22Rik
Summary: Predicted to enable heme binding activity and heme transmembrane transporter activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic digit morphogenesis; and hematopoietic or lymphoid organ development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Is expressed in ectoplacental cone; immune system; liver; placenta; and yolk sac. Used to study Diamond-Blackfan anemia. Orthologous to human FLVCR1 (FLVCR heme transporter 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in small intestine adult (RPKM 10.5), thymus adult (RPKM 9.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 96.28 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (190738029..190758387, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (191005832..191026190, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis.
Title: Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis.
study found that primary and immortalized murine macrophages downregulate Flvcr mRNA levels upon LPS stimulation; findings point to a new role for FLVCR and heme export in macrophages responses to infection and inflammation
Title: TLR Stimulation Dynamically Regulates Heme and Iron Export Gene Expression in Macrophages.
Data shows that FLVCR1a participates in the control of intestinal mucosa homeostasis by exporting the excess of de novo synthesized heme from intestinal cells.
Title: Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis.
These studies identify a novel and unexpected role for FLVCR, a major facilitator superfamily metabolite transporter, in T cell development
Title: Heme exporter FLVCR is required for T cell development and peripheral survival.
Flvcr1a maintains a free heme pool that regulates heme synthesis and degradation as well as cytochromes P450 expression and activity.
Title: Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.
FLVCR is redundant in stem cells but has critical and contrasting stage-specific roles in discrete hematopoietic lineages
Title: FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function.
Hemochromatosis is associated not only with excessive accumulation of free iron in the retina and retinal pigment epithelium but also with excessive accumulation of heme.
Title: Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.
data show that FLVCR exports heme & is required by erythroid progenitors to complete terminal differentiation; data show that FLVCR functions in macrophage heme-iron recycling and that systemic iron balance involves heme-iron trafficking via FLVCR
Title: A heme export protein is required for red blood cell differentiation and iron homeostasis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234309

NoName (e-PCR)
- UniSTS:234310

Flvcr1 (e-PCR), detects polymorphism
- UniSTS:508518

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digit morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within head morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme export	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme export	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heme transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spleen development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heme transporter FLVCR1

Names: feline leukemia virus subgroup C receptor-related protein 1; major facilitator superfamily domain containing 7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081259.1 → NP_001074728.1 heme transporter FLVCR1 isoform 1

See identical proteins and their annotated locations for NP_001074728.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK036315, AK044206, AV018812, BC157992, BY314941

Consensus CDS

CCDS35823.1

UniProtKB/Swiss-Prot

B2RXV4

Related

ENSMUSP00000082777.5, ENSMUST00000085635.6

Conserved Domains (2) summary

cd06174
Location:104 → 518

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:106 → 483

MFS_1; Major Facilitator Superfamily
NM_001313747.1 → NP_001300676.1 heme transporter FLVCR1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AK036315, AK044206, AV018812, BC157992, BY314941

UniProtKB/Swiss-Prot

B2RXV4

Conserved Domains (3) summary

cd06174
Location:192 → 372

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:161 → 337

MFS_1; Major Facilitator Superfamily

cl12078
Location:7 → 112

p450; Cytochrome P450
NM_198025.2 → NP_932142.2 heme transporter FLVCR1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks multiple 3' coding exons and its transcription extends past a splice site used in variant 1, resulting in a different 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC138229

Consensus CDS

CCDS83664.1

UniProtKB/TrEMBL

A0A0A6YWJ7, A0A0A6YXG8

Related

ENSMUSP00000141578.2, ENSMUST00000191946.2

Conserved Domains (2) summary

cd06174
Location:104 → 240

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:106 → 240

MFS_1; Major Facilitator Superfamily