Smyd2 SET and MYND domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Smyd2provided by MGI
Official Full Name: SET and MYND domain containing 2provided by MGI
Primary source: MGI:MGI:1915889
See related: Ensembl:ENSMUSG00000026603 AllianceGenome:MGI:1915889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KMT3C; Zmynd14; 4930402C15; 1110020E07Rik
Summary: Enables RNA polymerase II complex binding activity and histone methyltransferase activity (H3-K36 specific). Involved in negative regulation of cell population proliferation and peptidyl-lysine dimethylation. Acts upstream of or within histone methylation. Located in cytosol and nucleus. Is expressed in several structures, including heart; hemolymphoid system gland; nasal cavity epithelium; nervous system; and retina. Orthologous to human SMYD2 (SET and MYND domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 31.3), heart adult (RPKM 30.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 95.03 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (189612689..189654758, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (189880492..189922495, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide.
Title: Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide.
SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin.
Title: SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin.
Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation.
Title: Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation.
Histone methyltransferase Smyd2 contributes to blood-brain barrier breakdown in stroke.
Title: Histone methyltransferase Smyd2 contributes to blood-brain barrier breakdown in stroke.
SMYD2 suppresses p53 activity to promote glucose metabolism in cervical cancer.
Title: SMYD2 suppresses p53 activity to promote glucose metabolism in cervical cancer.
Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis.
Title: Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis.
Our data indicate that Smyd2 has a critical role downstream of Myc in acute myeloid leukemia
Title: Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis.
two positive feedback loops that integrate epigenetic regulation and renal inflammation in cyst development: SMYD2/IL-6/STAT3/SMYD2 and SMYD2/TNF-alpha/NF-kappaB/SMYD2.
Title: Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.
a pivotal role for SMYD2 in promoting pancreatic cancer.
Title: Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.
Data show that histone methyltransferase Smyd2 inhibits macrophage interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production. production.
Title: The histone methyltransferase Smyd2 is a negative regulator of macrophage activation by suppressing interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) production.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit409 (e-PCR), detects polymorphism
- UniSTS:128771

D1Mit409.1 (e-PCR), detects polymorphism
- UniSTS:128772

D1Mit117 (e-PCR), detects polymorphism
- UniSTS:128450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K36 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K4 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine dimethylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-lysine monomethylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: N-lysine methyltransferase SMYD2

Names: SET and MYND domain-containing protein 2; histone methyltransferase SMYD2

NP_081072.1

EC 2.1.1.354

XP_006497209.1

EC 2.1.1.354

XP_006497210.1

EC 2.1.1.354

XP_017175675.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026796.2 → NP_081072.1 N-lysine methyltransferase SMYD2

See identical proteins and their annotated locations for NP_081072.1

Status: VALIDATED

Source sequence(s)

AC140250, AK003853, AK150857, W76826

Consensus CDS

CCDS35821.1

UniProtKB/Swiss-Prot

Q3UBQ2, Q8R5A0

Related

ENSMUSP00000027897.8, ENSMUST00000027897.8

Conserved Domains (3) summary

pfam13424
Location:381 → 426

TPR_12; Tetratricopeptide repeat

cd19202
Location:7 → 269

SET_SMYD2; SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins

pfam01753
Location:52 → 90

zf-MYND; MYND finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

189612689..189654758 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497146.5 → XP_006497209.1 N-lysine methyltransferase SMYD2 isoform X1

Conserved Domains (2) summary

pfam13424
Location:344 → 389

TPR_12; Tetratricopeptide repeat

cd19202
Location:7 → 232

SET_SMYD2; SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins
XM_017320186.1 → XP_017175675.1 N-lysine methyltransferase SMYD2 isoform X3

UniProtKB/TrEMBL

Q9D177

Conserved Domains (2) summary

pfam13424
Location:177 → 222

TPR_12; Tetratricopeptide repeat

cl40432
Location:1 → 65

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
XM_006497147.5 → XP_006497210.1 N-lysine methyltransferase SMYD2 isoform X2

Conserved Domains (2) summary

pfam01753
Location:52 → 90

zf-MYND; MYND finger

cl40432
Location:7 → 178

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily