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    Wdr26 WD repeat domain 26 [ Mus musculus (house mouse) ]

    Gene ID: 226757, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Wdr26provided by MGI
    Official Full Name
    WD repeat domain 26provided by MGI
    Primary source
    MGI:MGI:1923825
    See related
    Ensembl:ENSMUSG00000038733 AllianceGenome:MGI:1923825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gid7; 1600024A01Rik
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of GID complex and ubiquitin ligase complex. Orthologous to human WDR26 (WD repeat domain 26). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 34.5), liver E14.5 (RPKM 31.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H4; 1 84.53 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (181000791..181046211, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (181173226..181220921, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 3, pseudogene Neighboring gene nuclear VCP-like Neighboring gene STARR-positive B cell enhancer ABC_E2593 Neighboring gene STARR-positive B cell enhancer ABC_E2026 Neighboring gene cornichon family AMPA receptor auxiliary protein 4 Neighboring gene predicted gene, 50602 Neighboring gene predicted gene, 38664 Neighboring gene STARR-positive B cell enhancer ABC_E5875 Neighboring gene ribosomal protein L35A, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E4401 Neighboring gene STARR-seq mESC enhancer starr_03234 Neighboring gene STARR-seq mESC enhancer starr_03237 Neighboring gene HAUS augmin-like complex, subunit 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WDR26 and MTF2 are therapeutic targets in multiple myeloma. Sun F, et al. J Hematol Oncol, 2021 Dec 7. PMID 34876184, Free PMC Article
    2. The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration. Sun Z, et al. J Biol Chem, 2011 Dec 23. PMID 22065575, Free PMC Article
    3. The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. Dell EJ, et al. J Biol Chem, 2002 Dec 20. PMID 12359736
    4. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, et al. Cell Rep, 2021 Jun 22. PMID 34161765
    5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WDR26 and MTF2 are therapeutic targets in multiple myeloma.
      Title: WDR26 and MTF2 are therapeutic targets in multiple myeloma.
    2. WDR26 is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration
      Title: The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403581.1 → NP_001390510.1  WD repeat-containing protein 26 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113084

    2. NM_001403582.1 → NP_001390511.1  WD repeat-containing protein 26 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113084

    3. NM_001403583.1 → NP_001390512.1  WD repeat-containing protein 26 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113084
      UniProtKB/TrEMBL
      E0CYH4
      Related
      ENSMUSP00000124186.2, ENSMUST00000162963.8

    4. NM_001403584.1 → NP_001390513.1  WD repeat-containing protein 26 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113084

    5. NM_001403585.1 → NP_001390514.1  WD repeat-containing protein 26 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC113084

    6. NM_001403586.1 → NP_001390515.1  WD repeat-containing protein 26 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC113084

    7. NM_001403587.1 → NP_001390516.1  WD repeat-containing protein 26 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC113084

    8. NM_001403588.1 → NP_001390517.1  WD repeat-containing protein 26 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC113084

    9. NM_001403589.1 → NP_001390518.1  WD repeat-containing protein 26 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC113084

    10. NM_145514.6 → NP_663489.4  WD repeat-containing protein 26 isoform 1

      See identical proteins and their annotated locations for NP_663489.4

      Status: VALIDATED

      Source sequence(s)
      AC113084
      Consensus CDS
      CCDS15583.2
      UniProtKB/Swiss-Prot
      E9PX83, Q3TK81, Q8C4F3, Q8C6G8, Q8VDZ6
      UniProtKB/TrEMBL
      A0A494BB75
      Related
      ENSMUSP00000124592.2, ENSMUST00000162819.9
      Conserved Domains (4) summary
      smart00668
      Location:136 → 211
      CTLH; C-terminal to LisH motif
      COG2319
      Location:326 → 621
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:329 → 621
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:339 → 379
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_175389.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113084

    2. NR_175390.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113084

    3. NR_175391.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113084

    4. NR_175392.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113084

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      181000791..181046211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496816.5 → XP_006496879.1  WD repeat-containing protein 26 isoform X1

      UniProtKB/TrEMBL
      A0A494BB75
      Conserved Domains (4) summary
      smart00668
      Location:136 → 211
      CTLH; C-terminal to LisH motif
      cd00200
      Location:329 → 621
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:339 → 379
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:106 → 133
      LisH_TPL; LisH-like dimerisation domain

    RNA

    1. XR_004941928.1 RNA Sequence

    2. XR_373606.5 RNA Sequence

    3. XR_003954940.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C6G8.3 GenPept UniProtKB/Swiss-Prot:Q8C6G8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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