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    Suco SUN domain containing ossification factor [ Mus musculus (house mouse) ]

    Gene ID: 226551, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sucoprovided by MGI
    Official Full Name
    SUN domain containing ossification factorprovided by MGI
    Primary source
    MGI:MGI:2138346
    See related
    Ensembl:ENSMUSG00000040297 AllianceGenome:MGI:2138346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Opt; 4732491B11
    Summary
    Involved in positive regulation of collagen biosynthetic process; positive regulation of osteoblast differentiation; and regulation of bone remodeling. Located in membrane and rough endoplasmic reticulum. Used to study osteogenesis imperfecta type 5. Orthologous to human SUCO (SUN domain containing ossification factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.6), bladder adult (RPKM 7.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H2.1; 1 69.95 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (161643681..161704506, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161816112..161876837, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7765 Neighboring gene STARR-seq mESC enhancer starr_02829 Neighboring gene predicted gene, 31869 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163734643-163734826 Neighboring gene Fas ligand Neighboring gene cyclin-dependent kinase 7 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10050 Neighboring gene STARR-positive B cell enhancer ABC_E2578 Neighboring gene STARR-positive B cell enhancer ABC_E7766 Neighboring gene STARR-seq mESC enhancer starr_02830 Neighboring gene predicted gene, 31925 Neighboring gene RIKEN cDNA 4930558K02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4367 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exome sequencing identifies SUCO mutations in mesial temporal lobe epilepsy. Sha Z, et al. Neurosci Lett, 2015 Mar 30. PMID 25668491
    2. Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. Sohaskey ML, et al. J Cell Biol, 2010 May 3. PMID 20440000, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. neurons have abnormal development due to lack of SUCO, which may be a generalized-onset epilepsy-related gene
      Title: Exome sequencing identifies SUCO mutations in mesial temporal lobe epilepsy.
    2. Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice.
      Title: Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC170004

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of collagen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of bone remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SUN domain-containing ossification factor
    Names
    SUN-like protein 1
    membrane protein CH1
    osteopotentia
    protein C1orf9 homolog
    protein osteopotentia

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357401.1 → NP_001344330.1  SUN domain-containing ossification factor isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164414
      Conserved Domains (2) summary
      pfam03938
      Location:936 → 1010
      OmpH; Outer membrane protein (OmpH-like)
      pfam07738
      Location:326 → 455
      Sad1_UNC; Sad1 / UNC-like C-terminal

    2. NM_001357402.1 → NP_001344331.1  SUN domain-containing ossification factor isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164414
      UniProtKB/Swiss-Prot
      Q3TAG8, Q3V3T1, Q8C341, Q8CE34
      Conserved Domains (2) summary
      pfam03938
      Location:932 → 1006
      OmpH; Outer membrane protein (OmpH-like)
      pfam07738
      Location:322 → 451
      Sad1_UNC; Sad1 / UNC-like C-terminal

    3. NM_172645.3 → NP_766233.2  SUN domain-containing ossification factor isoform 1 precursor

      See identical proteins and their annotated locations for NP_766233.2

      Status: VALIDATED

      Source sequence(s)
      AC164414
      Consensus CDS
      CCDS48415.1
      UniProtKB/TrEMBL
      B2RRF3
      Related
      ENSMUSP00000044815.6, ENSMUST00000048377.11
      Conserved Domains (2) summary
      pfam04899
      Location:936 → 1005
      MbeD_MobD; MbeD/MobD like
      pfam07738
      Location:326 → 455
      Sad1_UNC; Sad1 / UNC-like C-terminal

    RNA

    1. NR_151683.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164414

    2. NR_151684.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164414

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      161643681..161704506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496761.4 → XP_006496824.1  SUN domain-containing ossification factor isoform X1

      Conserved Domains (2) summary
      pfam04899
      Location:932 → 1001
      MbeD_MobD; MbeD/MobD like
      pfam07738
      Location:322 → 451
      Sad1_UNC; Sad1 / UNC-like C-terminal

    2. XM_017320016.3 → XP_017175505.1  SUN domain-containing ossification factor isoform X4

      Conserved Domains (2) summary
      pfam04899
      Location:936 → 1005
      MbeD_MobD; MbeD/MobD like
      pfam07738
      Location:326 → 455
      Sad1_UNC; Sad1 / UNC-like C-terminal

    3. XM_006496763.4 → XP_006496826.1  SUN domain-containing ossification factor isoform X3

      Conserved Domains (2) summary
      pfam04899
      Location:925 → 994
      MbeD_MobD; MbeD/MobD like
      pfam07738
      Location:322 → 444
      Sad1_UNC; Sad1 / UNC-like C-terminal

    4. XM_006496762.4 → XP_006496825.1  SUN domain-containing ossification factor isoform X2

      Conserved Domains (2) summary
      pfam04899
      Location:929 → 998
      MbeD_MobD; MbeD/MobD like
      pfam07738
      Location:326 → 448
      Sad1_UNC; Sad1 / UNC-like C-terminal

    5. XM_006496765.4 → XP_006496828.1  SUN domain-containing ossification factor isoform X5

      Conserved Domains (2) summary
      pfam04899
      Location:936 → 1005
      MbeD_MobD; MbeD/MobD like
      pfam07738
      Location:326 → 455
      Sad1_UNC; Sad1 / UNC-like C-terminal

    RNA

    1. XR_003954894.2 RNA Sequence

    2. XR_003954895.2 RNA Sequence

    3. XR_004941879.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C341.3 GenPept UniProtKB/Swiss-Prot:Q8C341

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