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    Rab29 RAB29, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 226422, updated on 9-May-2024

    Summary

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    Official Symbol
    Rab29provided by MGI
    Official Full Name
    RAB29, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:2385107
    See related
    Ensembl:ENSMUSG00000026433 AllianceGenome:MGI:2385107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab7l1
    Summary
    Enables GTP binding activity. Involved in cilium assembly and protein localization to ciliary membrane. Acts upstream of or within Golgi organization. Located in Golgi apparatus and vesicle. Orthologous to human RAB29 (RAB29, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 9.9), subcutaneous fat pad adult (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E4; 1 57.21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131795004..131801003)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131867210..131872887)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene peptidase M20 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02225 Neighboring gene STARR-positive B cell enhancer ABC_E8960 Neighboring gene solute carrier family 41, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E5799 Neighboring gene STARR-seq mESC enhancer starr_02227 Neighboring gene STARR-seq mESC enhancer starr_02228 Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene solute carrier family 45, member 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:133879500-133879800

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Combined Knockout of Lrrk2 and Rab29 Does Not Result in Behavioral Abnormalities in vivo. Mazza MC, et al. J Parkinsons Dis, 2021. PMID 33523017, Free PMC Article
    2. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Kalogeropulou AF, et al. Biochem J, 2020 Nov 27. PMID 33135724, Free PMC Article
    3. The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network. Beilina A, et al. Cell Rep, 2020 May 5. PMID 32375042, Free PMC Article
    4. LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts. Kuwahara T, et al. Sci Rep, 2016 Jul 18. PMID 27424887, Free PMC Article
    5. The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis. Onnis A, et al. Cell Death Differ, 2015 Oct. PMID 26021297, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.
      Title: Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.
    2. LRRK2 functions together with a second Parkinson's disease-associated gene, RAB7L1, within an evolutionarily conserved genetic module in diverse cellular contexts.
      Title: LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC28972, MGC36539

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular detoxification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in melanosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to ciliary membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of retrograde transport, endosome to Golgi NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in melanosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vacuole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras-related protein Rab-7L1
    Names
    RAB7, member RAS oncogene family-like 1
    rab-7-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421410.1 → NP_001408339.1  ras-related protein Rab-7L1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161805
      UniProtKB/TrEMBL
      E9QLQ7

    2. NM_001421411.1 → NP_001408340.1  ras-related protein Rab-7L1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161805

    3. NM_001421412.1 → NP_001408341.1  ras-related protein Rab-7L1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161805

    4. NM_001421413.1 → NP_001408342.1  ras-related protein Rab-7L1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161805

    5. NM_001421414.1 → NP_001408343.1  ras-related protein Rab-7L1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161805
      UniProtKB/TrEMBL
      E9QLQ7

    6. NM_144875.3 → NP_659124.2  ras-related protein Rab-7L1 isoform 1

      See identical proteins and their annotated locations for NP_659124.2

      Status: VALIDATED

      Source sequence(s)
      AC161805
      Consensus CDS
      CCDS15276.1
      UniProtKB/TrEMBL
      E9QLQ7
      Related
      ENSMUSP00000027693.8, ENSMUST00000027693.8
      Conserved Domains (2) summary
      smart00175
      Location:8 → 176
      RAB; Rab subfamily of small GTPases
      cd04107
      Location:8 → 204
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

    RNA

    1. NR_185300.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC161805

    2. NR_185301.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC161805

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131795004..131801003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YQ1.1 GenPept UniProtKB/Swiss-Prot:Q91YQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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