Plagl1 pleiomorphic adenoma gene-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plagl1provided by MGI
Official Full Name: pleiomorphic adenoma gene-like 1provided by MGI
Primary source: MGI:MGI:1100874
See related: Ensembl:ENSMUSG00000019817 AllianceGenome:MGI:1100874
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lot1; Zac1; 2610311E24Rik
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of gene expression and skeletal muscle cell differentiation. Predicted to be located in Golgi apparatus and nuclear body. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; heart; and sensory organ. Orthologous to human PLAGL1 (PLAG1 like zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 270.7), CNS E11.5 (RPKM 64.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A2; 10 4.72 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (12966576..13007438)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (13090832..13131694)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
Title: Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease.
Title: The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease.
Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome.
Title: Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome.
Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta.
Title: Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta.
PLAGL1 may regulate hypothalamic hypocretin transcription.
Title: Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription.
Zac1/GPR39 system promotes the formation of type II muscle fibers by phosphorylation of CaMK-II. Cells lacking Zac1/GPR39 system tend to remain stemness and form type I muscle fibers after induced differentiation.
Title: Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression.
Plagl1 is a transcription factor that coordinated the regulation of a subset of imprinted gene network genes and controlled extracellular matrix composition.
Title: Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network.
expression levels of Zac1 need to be kept under strict control to avoid premature cell cycle exit, disrupted neurogenesis and aberrant expression of non-neuronal genes including pluripotency associated factors.
Title: Elevated levels of ZAC1 disrupt neurogenesis and promote rapid in vivo reprogramming.
Transcription factor MEF2 and Zac1 mediate MIF-induced GLUT4 expression through CD74-dependent AMPK activation in cardiomyocytes
Title: Macrophage migration inhibitory factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes.
we show that the maternally imprinted gene Zac1 is a critical regulator of neocortical development
Title: Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236311

PMC85624P3 (e-PCR)
- UniSTS:273483

NoName (e-PCR)
- UniSTS:548427

Plagl1 (e-PCR), detects polymorphism
- UniSTS:532157

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein PLAGL1

Names: zinc finger protein regulator of apoptosis and cell cycle arrest

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364643.1 → NP_001351572.1 zinc finger protein PLAGL1 isoform b

Status: VALIDATED

Source sequence(s)

AK142052, AK142210, BC065150

Consensus CDS

CCDS87960.1

UniProtKB/TrEMBL

Q3UQW2

Related

ENSMUSP00000112889.2, ENSMUST00000121325.8

Conserved Domains (3) summary

COG5189
Location:29 → 109

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:6 → 26

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:49 → 73

zf-H2C2_2; Zinc-finger double domain
NM_001364644.1 → NP_001351573.1 zinc finger protein PLAGL1 isoform b

Status: VALIDATED

Source sequence(s)

AK142052, AK142210, BC065150

Consensus CDS

CCDS87960.1

UniProtKB/TrEMBL

Q3UQW2

Related

ENSMUSP00000113710.2, ENSMUST00000121766.8

Conserved Domains (3) summary

COG5189
Location:29 → 109

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:6 → 26

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:49 → 73

zf-H2C2_2; Zinc-finger double domain
NM_001364645.1 → NP_001351574.1 zinc finger protein PLAGL1 isoform b

Status: VALIDATED

Source sequence(s)

AL691505, AL713985

Consensus CDS

CCDS87960.1

UniProtKB/TrEMBL

Q3UQW2

Conserved Domains (3) summary

COG5189
Location:29 → 109

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:6 → 26

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:49 → 73

zf-H2C2_2; Zinc-finger double domain
NM_009538.3 → NP_033564.2 zinc finger protein PLAGL1 isoform a

See identical proteins and their annotated locations for NP_033564.2

Status: VALIDATED

Source sequence(s)

BC065150

Consensus CDS

CCDS48501.1

UniProtKB/TrEMBL

Q9JLQ4

Related

ENSMUSP00000112847.2, ENSMUST00000121646.8

Conserved Domains (2) summary

sd00017
Location:6 → 26

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:49 → 73

zf-H2C2_2; Zinc-finger double domain