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    Taf5 TATA-box binding protein associated factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 226182, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Taf5provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 5provided by MGI
    Primary source
    MGI:MGI:2442144
    See related
    Ensembl:ENSMUSG00000025049 AllianceGenome:MGI:2442144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330528C20Rik
    Summary
    Enables DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in embryo and tail. Orthologous to human TAF5 (TATA-box binding protein associated factor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 3.8), CNS E11.5 (RPKM 3.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 39.19 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47056187..47071918)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47067748..47083479)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene polycomb group ring finger 6 Neighboring gene STARR-positive B cell enhancer ABC_E11037 Neighboring gene STARR-seq mESC enhancer starr_46338 Neighboring gene predicted gene, 23140 Neighboring gene STARR-positive B cell enhancer ABC_E1979 Neighboring gene STARR-positive B cell enhancer ABC_E11038 Neighboring gene ATP synthase membrane subunit k Neighboring gene programmed cell death 11 Neighboring gene STARR-positive B cell enhancer ABC_E11039 Neighboring gene STARR-positive B cell enhancer ABC_E8754 Neighboring gene STARR-seq mESC enhancer starr_46339 Neighboring gene calcium homeostasis modulator family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A central role for TFIID in the pluripotent transcription circuitry. Pijnappel WW, et al. Nature, 2013 Mar 28. PMID 23503660
    2. An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability. Wansleeben C, et al. Mech Dev, 2011 May-Jun. PMID 21419221
    3. 8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. Ba X, et al. J Immunol, 2014 Mar 1. PMID 24489103, Free PMC Article
    4. Abnormal sperm in mice lacking the Taf7l gene. Cheng Y, et al. Mol Cell Biol, 2007 Apr. PMID 17242199, Free PMC Article
    5. The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. Le Douarin B, et al. EMBO J, 1995 May 1. PMID 7744009, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results show that nonproductive binding of OGG1 to 8-oxoG in promoter sequences could be an epigenetic mechanism to modulate gene expression for a prompt innate immune response.
      Title: 8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 5
    Names
    TAF(II)100
    TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
    TAFII-100
    TAFII100
    Tbp-associated factor 5
    transcription initiation factor TFIID 100 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177342.3 → NP_796316.2  transcription initiation factor TFIID subunit 5

      See identical proteins and their annotated locations for NP_796316.2

      Status: VALIDATED

      Source sequence(s)
      AC124724, AK031985, BQ714348, BU057827
      Consensus CDS
      CCDS29886.1
      UniProtKB/Swiss-Prot
      Q8BTR2, Q8C092
      UniProtKB/TrEMBL
      F8VPY2
      Related
      ENSMUSP00000026027.6, ENSMUST00000026027.7
      Conserved Domains (4) summary
      cd08044
      Location:212 → 344
      TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
      COG2319
      Location:460 → 741
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:473 → 743
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:474 → 542
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47056187..47071918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C092.1 GenPept UniProtKB/Swiss-Prot:Q8C092

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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