Hectd2 HECT domain E3 ubiquitin protein ligase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hectd2provided by MGI
Official Full Name: HECT domain E3 ubiquitin protein ligase 2provided by MGI
Primary source: MGI:MGI:2442663
See related: Ensembl:ENSMUSG00000041180 AllianceGenome:MGI:2442663
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4921524L07; A630025O09Rik
Summary: Predicted to enable ubiquitin-protein transferase activity. Is expressed in brain; large intestine; lymph node; and male reproductive gland or organ. Orthologous to human HECTD2 (HECT domain E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 4.4), whole brain E14.5 (RPKM 3.6) and 16 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 19 C2; 19 31.77 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (36531420..36598535)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (36554126..36621135)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

studies describe an unreported innate immune pathway and suggest that mutation or antagonism of the E3 ligase HECTD2 results in reduced severity of lung inflammation by selectively modulating the abundance of the anti-inflammatory protein PIAS1
Title: The proinflammatory role of HECTD2 in innate immunity and experimental lung injury.
Hectd2 is identified as a quantitative trait gene for prion disease incubation time in mice.
Title: HECTD2 is associated with susceptibility to mouse and human prion disease.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH140395 (e-PCR)
- UniSTS:222470

D11S3038 (e-PCR)
- UniSTS:152140

RH139463 (e-PCR)
- UniSTS:221549

RH118384 (e-PCR)
- UniSTS:160998

AW212605 (e-PCR)
- UniSTS:181228

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: probable E3 ubiquitin-protein ligase HECTD2

Names: HECT domain containing 2; HECT domain-containing protein 2; HECT-type E3 ubiquitin transferase HECTD2

NP_001156943.1

EC 2.3.2.26

NP_766225.2

EC 2.3.2.26

XP_006527054.1

EC 2.3.2.26

XP_017173648.1

EC 2.3.2.26

XP_030106754.1

EC 2.3.2.26

XP_030106755.1

EC 2.3.2.26

XP_036017457.1

EC 2.3.2.26

XP_036017458.1

EC 2.3.2.26

XP_036017459.1

EC 2.3.2.26

XP_036017460.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163471.1 → NP_001156943.1 probable E3 ubiquitin-protein ligase HECTD2 isoform 1

See identical proteins and their annotated locations for NP_001156943.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK029549, AK142777, BE864574, BP754340, CB526486

Consensus CDS

CCDS50425.1

UniProtKB/TrEMBL

B2RPZ5

Related

ENSMUSP00000128387.3, ENSMUST00000169036.9

Conserved Domains (2) summary

smart00119
Location:439 → 772

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:416 → 773

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_172637.3 → NP_766225.2 probable E3 ubiquitin-protein ligase HECTD2 isoform 2

See identical proteins and their annotated locations for NP_766225.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

AK029549, AK142777, BP754340, CB526486

Consensus CDS

CCDS29773.1

UniProtKB/Swiss-Prot

E9QK99, Q8CBQ9, Q8CDU6

Related

ENSMUSP00000042646.6, ENSMUST00000047247.12

Conserved Domains (2) summary

smart00119
Location:438 → 771

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:415 → 772

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

36531420..36598535

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526991.5 → XP_006527054.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X1

Conserved Domains (1) summary

cd00078
Location:313 → 670

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_036161567.1 → XP_036017460.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X6

Conserved Domains (1) summary

cd00078
Location:67 → 424

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_030250895.1 → XP_030106755.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X4

Conserved Domains (1) summary

cd00078
Location:154 → 511

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_036161564.1 → XP_036017457.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X3

Conserved Domains (1) summary

cd00078
Location:155 → 512

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_030250894.1 → XP_030106754.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X3

Conserved Domains (1) summary

cd00078
Location:155 → 512

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_036161565.1 → XP_036017458.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X4

Conserved Domains (1) summary

cd00078
Location:154 → 511

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_036161566.1 → XP_036017459.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X5

Conserved Domains (1) summary

cd00078
Location:68 → 425

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_017318159.3 → XP_017173648.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X2

Conserved Domains (1) summary

cd00078
Location:166 → 523

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...