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    Abhd17b abhydrolase domain containing 17B [ Mus musculus (house mouse) ]

    Gene ID: 226016, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Abhd17bprovided by MGI
    Official Full Name
    abhydrolase domain containing 17Bprovided by MGI
    Primary source
    MGI:MGI:1917816
    See related
    Ensembl:ENSMUSG00000047368 AllianceGenome:MGI:1917816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cgi67; Fam108b; Fam108b1; 5730446C15Rik
    Summary
    Enables palmitoyl-(protein) hydrolase activity. Involved in several processes, including negative regulation of protein localization to microtubule; positive regulation of protein localization to endosome; and protein depalmitoylation. Located in plasma membrane; postsynaptic density; and recycling endosome membrane. Orthologous to human ABHD17B (abhydrolase domain containing 17B, depalmitoylase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 19.0), cerebellum adult (RPKM 9.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 B; 19 15.54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (21630483..21663002)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (21653267..21685638)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38486 Neighboring gene RIKEN cDNA 1110059E24 gene Neighboring gene STARR-seq mESC enhancer starr_45727 Neighboring gene STARR-positive B cell enhancer mm9_chr19:21727198-21727499 Neighboring gene STARR-positive B cell enhancer mm9_chr19:21788111-21788412 Neighboring gene predicted gene, 41818 Neighboring gene STARR-positive B cell enhancer ABC_E9993 Neighboring gene STARR-positive B cell enhancer ABC_E9994 Neighboring gene VISTA enhancer mm1610 Neighboring gene STARR-seq mESC enhancer starr_45737 Neighboring gene STARR-seq mESC enhancer starr_45738 Neighboring gene cell migration inducing hyaluronidase 2 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Tortosa E, et al. Neuron, 2017 May 17. PMID 28521134
    2. Identification of PSD-95 Depalmitoylating Enzymes. Yokoi N, et al. J Neurosci, 2016 Jun 15. PMID 27307232, Free PMC Article
    3. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
    4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40949

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables palmitoyl-(protein) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein localization to microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein depalmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein depalmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein depalmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendritic spine maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha/beta hydrolase domain-containing protein 17B
    Names
    Cgi67 serine protease
    abhydrolase domain-containing protein 17B
    abhydrolase domain-containing protein FAM108B1
    family with sequence similarity 108, member B
    protein ABHD17B
    NP_666208.2
    XP_011245530.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146096.3 → NP_666208.2  alpha/beta hydrolase domain-containing protein 17B precursor

      See identical proteins and their annotated locations for NP_666208.2

      Status: VALIDATED

      Source sequence(s)
      AK050879, BM206433, BN000127
      Consensus CDS
      CCDS29700.1
      UniProtKB/Swiss-Prot
      Q58EV9, Q7M759, Q8K275
      Related
      ENSMUSP00000056099.4, ENSMUST00000052556.5
      Conserved Domains (1) summary
      COG1073
      Location:93 → 285
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      21630483..21663002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247228.4 → XP_011245530.1  alpha/beta hydrolase domain-containing protein 17B isoform X1

      See identical proteins and their annotated locations for XP_011245530.1

      UniProtKB/Swiss-Prot
      Q58EV9, Q7M759, Q8K275
      Conserved Domains (1) summary
      COG1073
      Location:93 → 285
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7M759.1 GenPept UniProtKB/Swiss-Prot:Q7M759

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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