Myrf myelin regulatory factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myrfprovided by MGI
Official Full Name: myelin regulatory factorprovided by MGI
Primary source: MGI:MGI:2684944
See related: Ensembl:ENSMUSG00000036098 AllianceGenome:MGI:2684944
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mrf; Gm98; Gm1804; 6030439E18
Summary: Enables DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including central nervous system myelin maintenance; positive regulation of myelination; and regulation of transcription, DNA-templated. Located in endoplasmic reticulum membrane and nucleus. Is expressed in pigmented retinal epithelium; spinal cord; and spinal cord marginal layer. Orthologous to human MYRF (myelin regulatory factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in stomach adult (RPKM 39.8), duodenum adult (RPKM 16.3) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.54 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10185635..10218134, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10208271..10240777, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis.
Title: Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis.
DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact.
Title: DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact.
Nanophthalmos-Associated MYRF Gene Mutation Causes Ciliary Zonule Defects in Mice.
Title: Nanophthalmos-Associated MYRF Gene Mutation Causes Ciliary Zonule Defects in Mice.
findings highlight the importance of the interplay between TMEM98 and MYRF in determining the size of the eye
Title: The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.
this study identifies the N-terminal-most domain as the transactivation domain of Myrf.
Title: Elucidating the transactivation domain of the pleiotropic transcription factor Myrf.
TMEM98 membrane protein physically interacts with MYRF in the endoplasmic reticulum and subsequently blocks its self-cleavage.
Title: Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein.
results thus suggest that Fbxw7 controls the transcription of MyRF target genes in various tissues through regulation of MyRF protein stability in a manner dependent on MyRF phosphorylation by GSK-3.
Title: Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCF(Fbxw7) in a manner dependent on the kinase GSK-3.
Purification, crystallization and X-ray analysis of DNA-binding domain of MRF has been reported.
Title: DNA-binding domain of myelin-gene regulatory factor: purification, crystallization and X-ray analysis.
molecular mechanisms underlying the homo-trimerization of Myrf N-terminal fragments and the homo-trimeric DNA binding of Myrf N-terminal fragments
Title: Homo-trimerization is essential for the transcription factor function of Myrf for oligodendrocyte differentiation.
mutant huntingtin binds abnormally to MYRF and affects its transcription activity
Title: Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in central nervous system myelin maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system myelin maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte development	IDA Inferred from Direct Assay more info	PubMed
involved_in oligodendrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoprocessing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myelin regulatory factor

Names: myelin gene regulatory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033481.2 → NP_001028653.1 myelin regulatory factor isoform 1

Status: VALIDATED

Source sequence(s)

AC132148

Consensus CDS

CCDS50387.1

UniProtKB/Swiss-Prot

Q3UR85

Related

ENSMUSP00000139601.2, ENSMUST00000189897.2

Conserved Domains (4) summary

pfam05224
Location:393 → 540

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13884
Location:587 → 647

Peptidase_S74; Chaperone of endosialidase

pfam13887
Location:667 → 702

MRF_C1; Myelin gene regulatory factor -C-terminal domain 1

pfam13888
Location:977 → 1108

MRF_C2; Myelin gene regulatory factor C-terminal domain 2
NM_001404113.1 → NP_001391042.1 myelin regulatory factor isoform 2

Status: VALIDATED

Source sequence(s)

AC132148

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

10185635..10218134 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526931.5 → XP_006526994.1 myelin regulatory factor isoform X6

Conserved Domains (5) summary

PHA03247
Location:857 → 1068

PHA03247; large tegument protein UL36; Provisional

TIGR02600
Location:769 → 885

Verru_Chthon_A; Verru_Chthon cassette protein A

pfam05224
Location:393 → 540

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:981 → 1112

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cd10144
Location:587 → 705

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
XM_006526930.5 → XP_006526993.1 myelin regulatory factor isoform X5

Conserved Domains (4) summary

PHA03247
Location:858 → 1069

PHA03247; large tegument protein UL36; Provisional

pfam05224
Location:393 → 540

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:982 → 1113

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cd10144
Location:587 → 705

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
XM_011247222.3 → XP_011245524.1 myelin regulatory factor isoform X2

Conserved Domains (4) summary

PHA03247
Location:816 → 1095

PHA03247; large tegument protein UL36; Provisional

pfam05224
Location:393 → 540

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:1008 → 1139

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cd10144
Location:587 → 705

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
XM_006526927.4 → XP_006526990.1 myelin regulatory factor isoform X1

Conserved Domains (4) summary

PHA03247
Location:816 → 1096

PHA03247; large tegument protein UL36; Provisional

pfam05224
Location:393 → 540

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:1009 → 1140

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cd10144
Location:587 → 705

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
XM_006526934.4 → XP_006526997.1 myelin regulatory factor isoform X9

Related

ENSMUSP00000140871.2, ENSMUST00000186056.7

Conserved Domains (4) summary

PHA03247
Location:728 → 1008

PHA03247; large tegument protein UL36; Provisional

pfam05224
Location:305 → 452

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:921 → 1052

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cd10144
Location:499 → 617

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
XM_006526932.4 → XP_006526995.1 myelin regulatory factor isoform X7

Conserved Domains (5) summary

PHA03247
Location:857 → 1063

PHA03247; large tegument protein UL36; Provisional

TIGR02600
Location:769 → 885

Verru_Chthon_A; Verru_Chthon cassette protein A

pfam05224
Location:393 → 540

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:976 → 1107

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cd10144
Location:587 → 705

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
XM_006526929.5 → XP_006526992.1 myelin regulatory factor isoform X4

See identical proteins and their annotated locations for XP_006526992.1

UniProtKB/Swiss-Prot

B2RXQ7, F8WJJ9, Q3UR85, Q3V3K4

Related

ENSMUSP00000085329.7, ENSMUST00000088013.12

Conserved Domains (4) summary

PHA03247
Location:816 → 1090

PHA03247; large tegument protein UL36; Provisional

pfam05224
Location:393 → 540

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:1003 → 1134

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cd10144
Location:587 → 705

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
XM_006526928.5 → XP_006526991.1 myelin regulatory factor isoform X3

Conserved Domains (4) summary

PHA03247
Location:816 → 1091

PHA03247; large tegument protein UL36; Provisional

pfam05224
Location:393 → 540

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:1004 → 1135

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cd10144
Location:587 → 705

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
XM_036161545.1 → XP_036017438.1 myelin regulatory factor isoform X11

Conserved Domains (4) summary

PHA03247
Location:770 → 976

PHA03247; large tegument protein UL36; Provisional

cd10144
Location:499 → 617

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins

pfam05224
Location:305 → 452

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:889 → 1020

MRF_C2; Myelin gene regulatory factor C-terminal domain 2
XM_036161543.1 → XP_036017436.1 myelin regulatory factor isoform X8

Conserved Domains (4) summary

PHA03247
Location:696 → 976

PHA03247; large tegument protein UL36; Provisional

cd10144
Location:467 → 585

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins

pfam05224
Location:273 → 420

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:889 → 1020

MRF_C2; Myelin gene regulatory factor C-terminal domain 2