Eml3 echinoderm microtubule associated protein like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eml3provided by MGI
Official Full Name: echinoderm microtubule associated protein like 3provided by MGI
Primary source: MGI:MGI:2387612
See related: Ensembl:ENSMUSG00000071647 AllianceGenome:MGI:2387612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Emap-3
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; mitotic metaphase plate congression; and regulation of mitotic spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in several cellular components, including midbody; mitotic spindle microtubule; and nucleus. Predicted to colocalize with mitotic spindle. Orthologous to human EML3 (EMAP like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 29.9), spleen adult (RPKM 28.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.04 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8904584..8918946)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8929663..8941582)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
colocalizes_with mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: echinoderm microtubule-associated protein-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374671.1 → NP_001361600.1 echinoderm microtubule-associated protein-like 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC129217, BC034112

UniProtKB/TrEMBL

A0A286YDN1

Related

ENSMUSP00000153500.2, ENSMUST00000224272.2

Conserved Domains (3) summary

sd00039
Location:517 → 555

7WD40; WD40 repeat [structural motif]

pfam03451
Location:215 → 284

HELP; HELP motif

cl29593
Location:551 → 868

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_144872.1 → NP_659121.1 echinoderm microtubule-associated protein-like 3 isoform 1

See identical proteins and their annotated locations for NP_659121.1

Status: VALIDATED

Source sequence(s)

BC022146

Consensus CDS

CCDS29560.1

UniProtKB/Swiss-Prot

Q8R1S1, Q8VC03

Related

ENSMUSP00000093960.5, ENSMUST00000096241.6

Conserved Domains (4) summary

sd00039
Location:518 → 556

7WD40; WD40 repeat [structural motif]

pfam03451
Location:216 → 285

HELP; HELP motif

cd21949
Location:6 → 34

TD_EMAP3; trimerization domain of echinoderm microtubule-associated protein-like 3

cl29593
Location:552 → 869

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

8904584..8918946

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161541.1 → XP_036017434.1 echinoderm microtubule-associated protein-like 3 isoform X2

Conserved Domains (3) summary

sd00039
Location:489 → 527

7WD40; WD40 repeat [structural motif]

pfam03451
Location:187 → 256

HELP; HELP motif

cl29593
Location:523 → 840

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036161540.1 → XP_036017433.1 echinoderm microtubule-associated protein-like 3 isoform X1

UniProtKB/Swiss-Prot

Q8R1S1, Q8VC03

Conserved Domains (4) summary

sd00039
Location:518 → 556

7WD40; WD40 repeat [structural motif]

pfam03451
Location:216 → 285

HELP; HELP motif

cd21949
Location:6 → 34

TD_EMAP3; trimerization domain of echinoderm microtubule-associated protein-like 3

cl29593
Location:552 → 869

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...