Cd226 CD226 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd226provided by MGI
Official Full Name: CD226 antigenprovided by MGI
Primary source: MGI:MGI:3039602
See related: Ensembl:ENSMUSG00000034028 AllianceGenome:MGI:3039602
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pta1; DNAM1; DNAM-1; TLiSA1
Summary: Predicted to enable integrin binding activity and protein kinase binding activity. Acts upstream of or within positive regulation of interferon-gamma production and positive regulation of natural killer cell cytokine production. Located in external side of plasma membrane. Is expressed in embryo. Orthologous to human CD226 (CD226 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 18 E4; 18 59.05 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (89195078..89290356)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (89176954..89272232)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions.
Title: CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions.
Integrated single-cell and bulk sequencing analyses with experimental validation identify the prognostic and immunological implications of CD226 in pan-cancer.
Title: Integrated single-cell and bulk sequencing analyses with experimental validation identify the prognostic and immunological implications of CD226 in pan-cancer.
Competitive binding of CD226/TIGIT with poliovirus receptor regulates macrophage polarization and is involved in vascularized skin graft rejection.
Title: Competitive binding of CD226/TIGIT with poliovirus receptor regulates macrophage polarization and is involved in vascularized skin graft rejection.
CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ-induced diabetic mice.
Title: CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ-induced diabetic mice.
Ablation of CD226 on CD4[+] T cells modulates asthma progress associated with altered IL-10 response and gut microbiota.
Title: Ablation of CD226 on CD4(+) T cells modulates asthma progress associated with altered IL-10 response and gut microbiota.
CD226 knockout reduces the development of CD8+ T by impairing the TCR sensitivity of double-positive thymocytes.
Title: CD226 knockout reduces the development of CD8+ T by impairing the TCR sensitivity of double-positive thymocytes.
[Knockout of CD226 alleviates depression-like behavior induced by chronic restraint stress in mice by modulating the ratio of immune cells in spleen and intestine].
Title: [Knockout of CD226 alleviates depression-like behavior induced by chronic restraint stress in mice by modulating the ratio of immune cells in spleen and intestine].
[DNAM-1 regulates the proliferation and function of T regulatory type 1 cells via the IL-2/STAT5 pathway].
Title: [DNAM-1 regulates the proliferation and function of T regulatory type 1 cells via the IL-2/STAT5 pathway].
Loss of CD226 protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.
Title: Loss of CD226 protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.
DNAM-1 promotes inflammation-driven tumor development via enhancing IFN-gamma production.
Title: DNAM-1 promotes inflammation-driven tumor development via enhancing IFN-γ production.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Markers

Cd226 (e-PCR), detects polymorphism
- UniSTS:508510

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cytokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of natural killer cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CD226 antigen

Names: platelet and T cell activation antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039149.1 → NP_001034238.1 CD226 antigen isoform b precursor

See identical proteins and their annotated locations for NP_001034238.1

Status: VALIDATED

Source sequence(s)

AC116387, AF421199

Consensus CDS

CCDS29391.1

UniProtKB/TrEMBL

Q8K4E3

Related

ENSMUSP00000095104.3, ENSMUST00000097496.4

Conserved Domains (2) summary

smart00410
Location:26 → 124

IG_like; Immunoglobulin like

cl11960
Location:24 → 113

Ig; Immunoglobulin domain
NM_178687.2 → NP_848802.2 CD226 antigen isoform a precursor

See identical proteins and their annotated locations for NP_848802.2

Status: VALIDATED

Source sequence(s)

AC116387, AK140349

Consensus CDS

CCDS29392.1

UniProtKB/Swiss-Prot

Q8K4F0

UniProtKB/TrEMBL

Q5DW69

Related

ENSMUSP00000043551.6, ENSMUST00000037142.13

Conserved Domains (3) summary

cd00096
Location:130 → 134

Ig; Ig strand A [structural motif]

cd05889
Location:17 → 128

IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains

cl11960
Location:137 → 225

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

89195078..89290356

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526463.1 → XP_006526526.1 CD226 antigen isoform X4

Conserved Domains (1) summary

cl11960
Location:21 → 110

Ig; Immunoglobulin domain
XM_006526461.1 → XP_006526524.1 CD226 antigen isoform X1

Conserved Domains (1) summary

cl11960
Location:52 → 149

Ig; Immunoglobulin domain
XM_017317894.1 → XP_017173383.1 CD226 antigen isoform X3

Conserved Domains (1) summary

cl11960
Location:45 → 134

Ig; Immunoglobulin domain
XM_036161134.1 → XP_036017027.1 CD226 antigen isoform X2

UniProtKB/Swiss-Prot

Q8K4F0

UniProtKB/TrEMBL

Q5DW69

Related

ENSMUSP00000158324.2, ENSMUST00000236828.2

Conserved Domains (3) summary

cd00096
Location:130 → 134

Ig; Ig strand A [structural motif]

cd05889
Location:17 → 128

IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains

cl11960
Location:137 → 225

Ig; Immunoglobulin domain
XM_006526464.5 → XP_006526527.1 CD226 antigen isoform X5

See identical proteins and their annotated locations for XP_006526527.1

UniProtKB/TrEMBL

Q8K4E2

Related

ENSMUSP00000158239.2, ENSMUST00000236452.2
XM_006526462.5 → XP_006526525.1 CD226 antigen isoform X2

See identical proteins and their annotated locations for XP_006526525.1

UniProtKB/Swiss-Prot

Q8K4F0

UniProtKB/TrEMBL

Q5DW69

Conserved Domains (3) summary

cd00096
Location:130 → 134

Ig; Ig strand A [structural motif]

cd05889
Location:17 → 128

IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains

cl11960
Location:137 → 225

Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001039148.1: Suppressed sequence

Description

NM_001039148.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.