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    Apbb3 amyloid beta precursor protein binding family B member 3 [ Mus musculus (house mouse) ]

    Gene ID: 225372, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Apbb3provided by MGI
    Official Full Name
    amyloid beta precursor protein binding family B member 3provided by MGI
    Primary source
    MGI:MGI:108404
    See related
    Ensembl:ENSMUSG00000117679 AllianceGenome:MGI:108404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TR2S; Rirl2; Fe65l2
    Summary
    Predicted to enable amyloid-beta binding activity and low-density lipoprotein particle receptor binding activity. Predicted to be involved in negative regulation of cell cycle phase transition; negative regulation of transcription by RNA polymerase II; and positive regulation of protein secretion. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in actin cytoskeleton; cytosol; and membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human APBB3 (amyloid beta precursor protein binding family B member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 17.9), cerebellum adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 B2; 18 19.46 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36804207..36812419, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36671154..36679366, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E5653 Neighboring gene steroid receptor RNA activator 1 Neighboring gene STARR-positive B cell enhancer ABC_E8708 Neighboring gene solute carrier family 35, member A4 Neighboring gene Riken cDNA E230025N22 gene Neighboring gene STARR-seq mESC enhancer starr_44297 Neighboring gene predicted gene, 41699

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo. Pappolla MA, et al. Am J Pathol, 1998 Apr. PMID 9546346, Free PMC Article
    2. Regulation of tumor necrosis factor-and Fas-mediated apoptotic cell death by a novel cDNA TR2L. Cao H, et al. Biochem Biophys Res Commun, 1996 Oct 3. PMID 8858135
    3. Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. Guénette S, et al. EMBO J, 2006 Jan 25. PMID 16407979, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38710

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    amyloid-beta A4 precursor protein-binding family B member 3
    Names
    amyloid beta (A4) precursor protein-binding, family B, member 3
    protein Fe65-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357512.1 → NP_001344441.1  amyloid-beta A4 precursor protein-binding family B member 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115631, AI844683
      Conserved Domains (3) summary
      smart00456
      Location:30 → 61
      WW; Domain with 2 conserved Trp (W) residues
      cd01271
      Location:284 → 414
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:116 → 255
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

    2. NM_146085.2 → NP_666197.1  amyloid-beta A4 precursor protein-binding family B member 3 isoform 1

      See identical proteins and their annotated locations for NP_666197.1

      Status: VALIDATED

      Source sequence(s)
      AI844683, BC024809
      Consensus CDS
      CCDS29157.1
      UniProtKB/Swiss-Prot
      Q8R1C9
      UniProtKB/TrEMBL
      Q3UR23
      Related
      ENSMUSP00000001415.8, ENSMUST00000001415.9
      Conserved Domains (3) summary
      smart00456
      Location:30 → 61
      WW; Domain with 2 conserved Trp (W) residues
      cd01271
      Location:283 → 413
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:116 → 254
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      36804207..36812419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161110.1 → XP_036017003.1  amyloid-beta A4 precursor protein-binding family B member 3 isoform X1

      Conserved Domains (2) summary
      cd01271
      Location:189 → 319
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:22 → 160
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1C9.1 GenPept UniProtKB/Swiss-Prot:Q8R1C9

    Gene LinkOut

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