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    Etf1 eukaryotic translation termination factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 225363, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Etf1provided by MGI
    Official Full Name
    eukaryotic translation termination factor 1provided by MGI
    Primary source
    MGI:MGI:2385071
    See related
    Ensembl:ENSMUSG00000024360 AllianceGenome:MGI:2385071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERF; ERF1; TB3-1; SUP45L1; D6Ertd109e
    Summary
    Predicted to enable sequence-specific mRNA binding activity and translation release factor activity, codon specific. Predicted to be involved in cytoplasmic translational termination and regulation of translational termination. Predicted to act upstream of or within protein methylation and translational termination. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Is expressed in central nervous system and retina. Orthologous to human ETF1 (eukaryotic translation termination factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 27.4), CNS E11.5 (RPKM 25.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 B1; 18 18.78 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35035838..35065060, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34902785..34932008, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:35020809-35020992 Neighboring gene early growth response 1 Neighboring gene predicted gene, 54018 Neighboring gene STARR-positive B cell enhancer ABC_E964 Neighboring gene heat shock protein 9 Neighboring gene predicted gene, 22200 Neighboring gene predicted gene, 26109

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination. Orlova M, et al. Cell, 2003 Oct 31. PMID 14636559
    2. Stop codon selection in eukaryotic translation termination: comparison of the discriminating potential between human and ciliate eRF1s. Chavatte L, et al. EMBO J, 2003 Apr 1. PMID 12660170, Free PMC Article
    3. Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms. Stoddart A, et al. Haematologica, 2016 Jun. PMID 26944478, Free PMC Article
    4. In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3. Alkalaeva EZ, et al. Cell, 2006 Jun 16. PMID 16777602
    5. CFIm-mediated alternative polyadenylation safeguards the development of mammalian pre-implantation embryos. Li N, et al. Stem Cell Reports, 2023 Jan 10. PMID 36563685, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms
      Title: Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
    2. Reverse Transcriptase enhances suppression of termination and that the interaction of RT with eRF1 is required for an appropriate level of translational readthrough.
      Title: Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18745

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation release factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation release factor activity, codon specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation termination factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein methylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of translation release factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic peptide chain release factor subunit 1
    Names
    eukaryotic release factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144866.3 → NP_659115.3  eukaryotic peptide chain release factor subunit 1

      See identical proteins and their annotated locations for NP_659115.3

      Status: VALIDATED

      Source sequence(s)
      AC114820, AI844751, AK169345, BY238984
      Consensus CDS
      CCDS29137.1
      UniProtKB/Swiss-Prot
      Q3TPZ6, Q8BWY3, Q91VH9
      UniProtKB/TrEMBL
      Q3TDF8, Q3TF02, Q3TL10
      Related
      ENSMUSP00000025218.8, ENSMUST00000025218.8
      Conserved Domains (1) summary
      COG1503
      Location:11 → 419
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      35035838..35065060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250436.2 → XP_030106296.1  eukaryotic peptide chain release factor subunit 1 isoform X1

      UniProtKB/TrEMBL
      Q3U6V5
      Conserved Domains (1) summary
      COG1503
      Location:1 → 386
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWY3.4 GenPept UniProtKB/Swiss-Prot:Q8BWY3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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