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    Fbxo11 F-box protein 11 [ Mus musculus (house mouse) ]

    Gene ID: 225055, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fbxo11provided by MGI
    Official Full Name
    F-box protein 11provided by MGI
    Primary source
    MGI:MGI:2147134
    See related
    Ensembl:ENSMUSG00000005371 AllianceGenome:MGI:2147134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jf
    Summary
    Enables ubiquitin-protein transferase activity. Involved in sensory perception of sound. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Used to study otitis media. Orthologous to human FBXO11 (F-box protein 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 23.5), whole brain E14.5 (RPKM 20.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo11 in Genome Data Viewer
    Location:
    17 E4; 17 57.87 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88298287..88373473, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87990859..88066045, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43521 Neighboring gene predicted gene, 41649 Neighboring gene STARR-seq mESC enhancer starr_43523 Neighboring gene STARR-seq mESC enhancer starr_43524 Neighboring gene STARR-seq mESC enhancer starr_43525 Neighboring gene STARR-seq mESC enhancer starr_43526 Neighboring gene STARR-seq mESC enhancer starr_43527 Neighboring gene ribosomal protein L36, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_43528 Neighboring gene STARR-seq mESC enhancer starr_43529 Neighboring gene STARR-seq mESC enhancer starr_43530 Neighboring gene STARR-positive B cell enhancer ABC_E9446 Neighboring gene STARR-seq mESC enhancer starr_43533 Neighboring gene STARR-positive B cell enhancer ABC_E7566 Neighboring gene mutS homolog 6 Neighboring gene STARR-positive B cell enhancer ABC_E8701 Neighboring gene STARR-positive B cell enhancer ABC_E4235 Neighboring gene STARR-positive B cell enhancer ABC_E5642 Neighboring gene STARR-positive B cell enhancer mm9_chr17:88465439-88465740 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:88465818-88465927 Neighboring gene STARR-seq mESC enhancer starr_43538 Neighboring gene STARR-positive B cell enhancer ABC_E1513 Neighboring gene STARR-positive B cell enhancer ABC_E5643 Neighboring gene STARR-seq mESC enhancer starr_43539 Neighboring gene predicted gene 4832 Neighboring gene predicted gene, 31499

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FBXO11 regulates bone development. Huang H, et al. Bone, 2023 May. PMID 36863499, Free PMC Article
    2. The Jeff Mouse Mutant Model for Chronic Otitis Media Manifests Gain-of-Function as Well as Loss-of-Function Effects. Kubinyecz O, et al. Front Genet, 2020. PMID 32508883, Free PMC Article
    3. Mutation in Fbxo11 Leads to Altered Immune Cell Content in Jeff Mouse Model of Otitis Media. Vikhe PP, et al. Front Genet, 2020. PMID 32117459, Free PMC Article
    4. Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity. Bagger SO, et al. Mol Cancer, 2018 Dec 10. PMID 30526604, Free PMC Article
    5. FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease. Schneider C, et al. Blood, 2016 Aug 4. PMID 27166359, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.
      Title: FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.
    2. FBXO11 regulates bone development.
      Title: FBXO11 regulates bone development.
    3. Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma.
      Title: Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma.
    4. a bulla cavitation defect initiates the pathogenesis of otitis media in the established mouse model Jeff (Fbxo11(Jf/+) ).
      Title: Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model.
    5. Through a loss-of-function screen authors found that a member of the E3 ubiquitin ligase complexes, FBXO11, specifically fuels tumor formation of a non-EMT-like clone by restraining the p53/p21 pathway. Interestingly, in the related EMT-like clone, FBXO11 operates through the BCL2 pathway with little or no impact on tumorigenesis.
      Title: Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity.
    6. FBXO11 inactivation was associated with the development of lymphoproliferative disorders in mice.
      Title: FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease.
    7. FBXO11 regulates the TGF-beta pathway in the embryonic lung via cross-talk with p53.
      Title: Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung.
    8. Relationship between dilation of endoplasmic reticulum and decreased levels of the FBXO11 gene in vitiligo melanocytes.
      Title: VIT1/FBXO11 knockdown induces morphological alterations and apoptosis in B10BR mouse melanocytes.
    9. FBXO11 is one of the first molecules to be identified, contributing to the genetic aetiology of otitis media
      Title: A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156416

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081034.3 → NP_001074503.1  F-box only protein 11 isoform 1

      See identical proteins and their annotated locations for NP_001074503.1

      Status: VALIDATED

      Source sequence(s)
      AC087233, AC154673, AI853268, BC055343, BY127063, CA557033, CA749247, CF169182, CF172333, CN533292, CN666984
      Consensus CDS
      CCDS37717.1
      UniProtKB/Swiss-Prot
      A1A595, E9QP06, Q08EB9, Q08EC0, Q7TPD1, Q80UP0
      Related
      ENSMUSP00000005504.9, ENSMUST00000005504.15
      Conserved Domains (3) summary
      pfam12937
      Location:160 → 203
      F-box-like; F-box-like
      pfam13229
      Location:667 → 812
      Beta_helix; Right handed beta helix region
      cl19744
      Location:853 → 894
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    2. NM_001348248.1 → NP_001335177.1  F-box only protein 11 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC087233, AC154673, BC055343, BY127063, CA557033, CA749247, CF169182, CF172333, CN533292, CN666984
      UniProtKB/Swiss-Prot
      Q7TPD1
      Conserved Domains (3) summary
      pfam12937
      Location:73 → 116
      F-box-like
      pfam13229
      Location:580 → 739
      Beta_helix; Right handed beta helix region
      cl19744
      Location:766 → 807
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    3. NM_001379303.1 → NP_001366232.1  F-box only protein 11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087233, AC154673
      Conserved Domains (3) summary
      pfam12937
      Location:159 → 202
      F-box-like
      pfam13229
      Location:666 → 825
      Beta_helix; Right handed beta helix region
      cl19744
      Location:852 → 893
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    4. NM_001379304.1 → NP_001366233.1  F-box only protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087233, AC154673
      Conserved Domains (3) summary
      pfam12937
      Location:73 → 116
      F-box-like
      pfam13229
      Location:580 → 739
      Beta_helix; Right handed beta helix region
      cl19744
      Location:766 → 807
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    5. NM_001379305.1 → NP_001366234.1  F-box only protein 11 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087233, AC154673
      Related
      ENSMUSP00000121206.3, ENSMUST00000130379.9
      Conserved Domains (3) summary
      pfam12937
      Location:72 → 115
      F-box-like
      pfam13229
      Location:579 → 738
      Beta_helix; Right handed beta helix region
      cl19744
      Location:765 → 806
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    6. NM_001414440.1 → NP_001401369.1  F-box only protein 11 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087233, AC154673

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      88298287..88373473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPD1.3 GenPept UniProtKB/Swiss-Prot:Q7TPD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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