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    Lclat1 lysocardiolipin acyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 225010, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Lclat1provided by MGI
    Official Full Name
    lysocardiolipin acyltransferase 1provided by MGI
    Primary source
    MGI:MGI:2684937
    See related
    Ensembl:ENSMUSG00000054469 AllianceGenome:MGI:2684937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm91; Lycat; Agpat8; Alcat1; 1-AGPAT 8
    Summary
    Enables acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Predicted to act upstream of or within phospholipid biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including arterial system; gonad; heart; immune system; and respiratory system. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 10.0), large intestine adult (RPKM 5.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E1.3- E2; 17 44.79 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (73414980..73550363)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (73107985..73243368)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43196 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:73403131-73403314 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:73403592-73403802 Neighboring gene predicted gene, 30476 Neighboring gene STARR-seq mESC enhancer starr_43198 Neighboring gene predicted gene, 41616 Neighboring gene STARR-seq mESC enhancer starr_43199 Neighboring gene STARR-positive B cell enhancer ABC_E8695 Neighboring gene STARR-seq mESC enhancer starr_43201 Neighboring gene STARR-positive B cell enhancer ABC_E7555 Neighboring gene predicted gene, 25406 Neighboring gene UDP-glucuronate decarboxylase 1 pseudogene Neighboring gene RIKEN cDNA E330032C10 gene Neighboring gene STARR-positive B cell enhancer ABC_E398 Neighboring gene STARR-positive B cell enhancer ABC_E10970 Neighboring gene STARR-positive B cell enhancer ABC_E7556 Neighboring gene calpain 13 Neighboring gene STARR-seq mESC enhancer starr_43202

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases. Song C, et al. Aging Cell, 2019 Jun. PMID 30838774, Free PMC Article
    2. ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis. Wang L, et al. Hepatology, 2015 Feb. PMID 25203315, Free PMC Article
    3. Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy. Liu X, et al. Mol Cell Biol, 2012 Nov. PMID 22949503, Free PMC Article
    4. Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Li J, et al. Cell Metab, 2010 Aug 4. PMID 20674860, Free PMC Article
    5. Expression of the Lycat gene in the mouse cardiovascular and female reproductive systems. Wang W, et al. Dev Dyn, 2010 Jun. PMID 20503378

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Irisin and ALCAT1 mediated aerobic exercise-alleviated oxidative stress and apoptosis in skeletal muscle of mice with myocardial infarction.
      Title: Irisin and ALCAT1 mediated aerobic exercise-alleviated oxidative stress and apoptosis in skeletal muscle of mice with myocardial infarction.
    2. Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation.
      Title: Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation.
    3. ALCAT1 expression is upregulated by MPTP and by alpha-synucleinopathy, a key hallmark of Parkinson's disease (PD), whereas ALCAT1 deficiency prevented alpha-synuclein oligomerization and S-129 phosphorylation, implicating a key role of ALCAT1 in the etiology of mouse models of PD.
      Title: Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases.
    4. Lycat regulates TGF-beta mediated lung fibroblast differentiation in pulmonary fibrosis.
      Title: Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation.
    5. Alcat1 is destabilized in epithelia by lipopolysaccharide (LPS) impairing mitochondrial function.
      Title: LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1.
    6. Differential reduction in cardiac and liver monolysocardiolipin acyltransferase-1 and reduction in cardiac and liver tetralinoleoyl-cardiolipin in the alpha-subunit of trifunctional protein heterozygous knockout mice
      Title: Differential reduction in cardiac and liver monolysocardiolipin acyltransferase-1 and reduction in cardiac and liver tetralinoleoyl-cardiolipin in the α-subunit of trifunctional protein heterozygous knockout mice.
    7. pathological cardiolipin remodeling by ALCAT1 linked to the pathogenesis of nonalcoholic fatty liver diseases
      Title: ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis.
    8. LYCAT expression was altered in peripheral blood mononuclear cells and outcome in pulmonary fibrosis.
      Title: The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.
    9. findings implicate a key role of ALCAT1 as the missing link between oxidative stress and mitochondrial dysfunction in the etiology of age-related heart diseases
      Title: Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy.
    10. overexpression of ALCAT1 causes mitochondrial fragmentation through oxidative stress and depletion of mitofusin mitofusin 2 (MFN2) expression
      Title: Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiolipin acyl-chain remodeling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysocardiolipin acyltransferase 1
    Names
    1-AGP acyltransferase 8
    1-acylglycerol-3-phosphate O-acyltransferase 8
    acyl-CoA:lysocardiolipin acyltransferase 1
    NP_001074540.1
    NP_001171438.1
    NP_001171439.1
    XP_036016461.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081071.2 → NP_001074540.1  lysocardiolipin acyltransferase 1

      See identical proteins and their annotated locations for NP_001074540.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC112949, AI847050, BB868193, BC158076
      Consensus CDS
      CCDS37689.1
      UniProtKB/Swiss-Prot
      Q3UN02
      UniProtKB/TrEMBL
      A0A3B2WDB3, B0V2Q7
      Related
      ENSMUSP00000068690.7, ENSMUST00000067545.8
      Conserved Domains (2) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233 → 302
      Acyltransf_C; Acyltransferase C-terminus

    2. NM_001177967.1 → NP_001171438.1  lysocardiolipin acyltransferase 1

      See identical proteins and their annotated locations for NP_001171438.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC112949, AI847050, BB868193, BC147499
      Consensus CDS
      CCDS37689.1
      UniProtKB/Swiss-Prot
      Q3UN02
      UniProtKB/TrEMBL
      A0A3B2WDB3, B0V2Q7
      Conserved Domains (2) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233 → 302
      Acyltransf_C; Acyltransferase C-terminus

    3. NM_001177968.1 → NP_001171439.1  lysocardiolipin acyltransferase 1

      See identical proteins and their annotated locations for NP_001171439.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC112949, AI847050, BB868193, BC150884
      Consensus CDS
      CCDS37689.1
      UniProtKB/Swiss-Prot
      Q3UN02
      UniProtKB/TrEMBL
      A0A3B2WDB3, B0V2Q7
      Related
      ENSMUSP00000156922.2, ENSMUST00000232703.2
      Conserved Domains (2) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233 → 302
      Acyltransf_C; Acyltransferase C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      73414980..73550363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160568.1 → XP_036016461.1  lysocardiolipin acyltransferase 1 isoform X1

      Conserved Domains (2) summary
      cd07990
      Location:171 → 364
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:349 → 422
      Acyltransf_C; Acyltransferase C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UN02.2 GenPept UniProtKB/Swiss-Prot:Q3UN02

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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