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    Pja2 praja ring finger ubiquitin ligase 2 [ Mus musculus (house mouse) ]

    Gene ID: 224938, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pja2provided by MGI
    Official Full Name
    praja ring finger ubiquitin ligase 2provided by MGI
    Primary source
    MGI:MGI:2159342
    See related
    Ensembl:ENSMUSG00000024083 AllianceGenome:MGI:2159342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Neurodap1; mKIAA0438
    Summary
    Predicted to enable protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including long-term memory; regulation of macrophage activation; and regulation of signal transduction. Predicted to be located in cytoplasm; intermediate filament cytoskeleton; and plasma membrane. Is expressed in nervous system and testis. Orthologous to human PJA2 (praja ring finger ubiquitin ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 42.7), cortex adult (RPKM 39.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E1.1; 17 33.24 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (64588001..64638878, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (64281006..64331883, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_42985 Neighboring gene STARR-seq mESC enhancer starr_42986 Neighboring gene STARR-seq mESC enhancer starr_42987 Neighboring gene predicted gene, 34858 Neighboring gene STARR-positive B cell enhancer ABC_E3212 Neighboring gene STARR-seq mESC enhancer starr_42988 Neighboring gene STARR-seq mESC enhancer starr_42989 Neighboring gene microRNA 6420 Neighboring gene expressed sequence AU016765 Neighboring gene predicted gene, 35098

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells. Gong M, et al. Am J Physiol Cell Physiol, 2020 Jun 1. PMID 32267716
    2. praja2 regulates KSR1 stability and mitogenic signaling. Rinaldi L, et al. Cell Death Dis, 2016 May 19. PMID 27195677, Free PMC Article
    3. Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway. Sepe M, et al. Proc Natl Acad Sci U S A, 2014 Nov 4. PMID 25331889, Free PMC Article
    4. Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation. Sakamaki J, et al. Nat Cell Biol, 2014 Mar. PMID 24561619, Free PMC Article
    5. PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. Yu P, et al. Genomics, 2002 Jun. PMID 12036302

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer.
      Title: Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer.
    2. Pja2 regulated hippocampal neuronal cell development and the expression of Alzheimer disease marker genes by inhibiting P2rx3/promoting P2rx7 expression.
      Title: Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells.
    3. praja2 regulates KSR1 stability and mitogenic signaling.
      Title: praja2 regulates KSR1 stability and mitogenic signaling.
    4. The SIK2-p35-PJA2 complex is essential for glucose homeostasis and provides a link between p35-CDK5 and the AMPK family in excitable cells.
      Title: Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27629

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-term memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of toll-like receptor 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein kinase A signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase Praja-2
    Names
    E3 ubiquitin-protein ligase Praja2
    RING finger protein 131
    RING-type E3 ubiquitin transferase Praja-2
    neurodegeneration associated protein 1
    praja 2, RING-H2 motif containing
    praja-2
    praja2
    protein carrying the RING-H2 sequence motif
    NP_001020480.1
    NP_659108.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025309.1 → NP_001020480.1  E3 ubiquitin-protein ligase Praja-2 isoform a

      See identical proteins and their annotated locations for NP_001020480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK122282, BY065517
      Consensus CDS
      CCDS37675.1
      UniProtKB/Swiss-Prot
      Q3TH95, Q80U04, Q810E3, Q91W46, Q99KC0
      Related
      ENSMUSP00000134380.2, ENSMUST00000172818.8
      Conserved Domains (1) summary
      pfam13639
      Location:633 → 674
      zf-RING_2; Ring finger domain

    2. NM_144859.2 → NP_659108.1  E3 ubiquitin-protein ligase Praja-2 isoform b

      See identical proteins and their annotated locations for NP_659108.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AA067149, AK122282, BC017130, BX518494, BY065517
      Consensus CDS
      CCDS37674.1
      UniProtKB/Swiss-Prot
      Q80U04
      Related
      ENSMUSP00000133730.2, ENSMUST00000172733.2
      Conserved Domains (1) summary
      pfam13639
      Location:571 → 612
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      64588001..64638878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80U04.2 GenPept UniProtKB/Swiss-Prot:Q80U04

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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