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    Dpp9 dipeptidylpeptidase 9 [ Mus musculus (house mouse) ]

    Gene ID: 224897, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dpp9provided by MGI
    Official Full Name
    dipeptidylpeptidase 9provided by MGI
    Primary source
    MGI:MGI:2443967
    See related
    Ensembl:ENSMUSG00000001229 AllianceGenome:MGI:2443967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DPRP2; DPP IX; A330078I11; 6430584G11Rik
    Summary
    Predicted to enable dipeptidyl-peptidase activity and identical protein binding activity. Predicted to be located in cell leading edge; cytosol; and microtubule. Is expressed in several structures, including forelimb bud; gut; male reproductive gland or organ; myotome; and nervous system. Orthologous to human DPP9 (dipeptidyl peptidase 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 24.7), thymus adult (RPKM 22.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 D; 17 29.2 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56493674..56525927, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56186674..56218889, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B Neighboring gene STARR-positive B cell enhancer ABC_E5621 Neighboring gene tumor necrosis factor, alpha-induced protein 8-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E7547 Neighboring gene myeloid derived growth factor Neighboring gene RIKEN cDNA A230051N06 gene Neighboring gene microRNA 7b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DPP9 enzymatic activity in hematopoietic cells is dispensable for mouse hematopoiesis. Kim M, et al. Immunol Lett, 2018 Jun. PMID 29709545
    2. Expression, subcellular localisation, and possible roles of dipeptidyl peptidase 9 (DPP9) in murine macrophages. Zapletal E, et al. Cell Biochem Funct, 2017 Mar. PMID 28256001
    3. Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes. Chen Y, et al. Exp Cell Res, 2016 Mar 1. PMID 26930324
    4. Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis. Zhang H, et al. FEBS J, 2015 Oct. PMID 26175140
    5. Targeted inactivation of dipeptidyl peptidase 9 enzymatic activity causes mouse neonate lethality. Gall MG, et al. PLoS One, 2013. PMID 24223149, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.
      Title: DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.
    2. Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity.
      Title: Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity.
    3. The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.
      Title: The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.
    4. Dipeptidyl peptidase 9 (DPP9) knock-in mice (DPP9(ki/ki) mice)express a catalytically inactive S729A mutant of DPP9 enzyme. DPP9(ki/ki) mice show reduced number of lymphoid and myeloid cells in fetal liver and postnatal blood but their hematopoietic cells are fully functional and able to reconstitute lymphoid and myeloid lineages even in competitive mixed chimeras.
      Title: DPP9 enzymatic activity in hematopoietic cells is dispensable for mouse hematopoiesis.
    5. lack of DPP9 activity in mice leads to impaired tongue development, suckling defect and subsequent neonatal lethality.
      Title: DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect.
    6. Changes induced by DPP9 gene silencing in macrophages suggest possible role of DPP9 in regulation of proliferation and activation status, as well as in peptide processing within endosomal/vesicular compartment.
      Title: Expression, subcellular localisation, and possible roles of dipeptidyl peptidase 9 (DPP9) in murine macrophages.
    7. DPP9 enzyme activity regulates metabolic pathways in neonatal liver and gut.
      Title: Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes.
    8. Blocking the expression or activities of DPP8 and DPP9 attenuates PPARgamma2 induction during preadipocyte differentiation.
      Title: Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation.
    9. Identification of novel dipeptidyl peptidase 9 substrates: discovering dipeptide Val-Ala as a consensus site for DPP9 cleavage
      Title: Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis.
    10. DPP9 enzymatic activity is essential for early neonatal survival in mice.
      Title: Targeted inactivation of dipeptidyl peptidase 9 enzymatic activity causes mouse neonate lethality.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (4)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_negative_effect pyroptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidyl peptidase 9
    Names
    DP9
    DPLP9
    dipeptidyl peptidase IX
    dipeptidyl peptidase-like protein 9
    NP_001347213.1
    NP_766212.2
    XP_006524218.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360284.1 → NP_001347213.1  dipeptidyl peptidase 9 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC026385
      Conserved Domains (2) summary
      pfam00326
      Location:720 → 921
      Peptidase_S9; Prolyl oligopeptidase family
      cl27623
      Location:204 → 628
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. NM_172624.3 → NP_766212.2  dipeptidyl peptidase 9 isoform 2

      See identical proteins and their annotated locations for NP_766212.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK050021, AK050023, AK078301
      Consensus CDS
      CCDS37663.1
      UniProtKB/Swiss-Prot
      Q6KAM9, Q8BVG4, Q8BWT9
      Related
      ENSMUSP00000046604.5, ENSMUST00000038794.6
      Conserved Domains (2) summary
      pfam00326
      Location:661 → 862
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:145 → 568
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56493674..56525927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524155.5 → XP_006524218.1  dipeptidyl peptidase 9 isoform X1

      See identical proteins and their annotated locations for XP_006524218.1

      UniProtKB/Swiss-Prot
      Q6KAM9, Q8BVG4, Q8BWT9
      Conserved Domains (2) summary
      pfam00326
      Location:661 → 862
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:145 → 568
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RNA

    1. XR_004939518.1 RNA Sequence

    2. XR_385319.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVG4.2 GenPept UniProtKB/Swiss-Prot:Q8BVG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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