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    Zfp959 zinc finger protein 959 [ Mus musculus (house mouse) ]

    Gene ID: 224893, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp959provided by MGI
    Official Full Name
    zinc finger protein 959provided by MGI
    Primary source
    MGI:MGI:2385058
    See related
    Ensembl:ENSMUSG00000003198 AllianceGenome:MGI:2385058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF101 (zinc finger protein 101) and ZNF699 (zinc finger protein 699). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 1.7), CNS E14 (RPKM 1.6) and 28 other tissues See more
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    Genomic context

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    Location:
    17 D; 17 29.05 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56199093..56205935)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55891084..55898935)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E4 Neighboring gene STARR-seq mESC enhancer starr_42871 Neighboring gene vomeronasal 2, receptor 121 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42872 Neighboring gene zinc finger protein 119a Neighboring gene STARR-positive B cell enhancer ABC_E2495 Neighboring gene predicted gene, 41603 Neighboring gene ribosomal protein L21, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_42873 Neighboring gene STARR-positive B cell enhancer ABC_E4220 Neighboring gene STARR-positive B cell enhancer ABC_E7546 Neighboring gene zinc finger protein 119b Neighboring gene predicted gene, 16712 Neighboring gene Epstein-Barr virus induced gene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18740

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC224893

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360136.1 → NP_001347065.1  uncharacterized protein LOC224893 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154235, CT573084
      Conserved Domains (4) summary
      COG5048
      Location:366 → 499
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:398 → 418
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1 → 41
      KRAB; KRAB box
      pfam13465
      Location:299 → 323
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001410544.1 → NP_001397473.1  uncharacterized protein LOC224893 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT573084

    3. NM_001410545.1 → NP_001397474.1  uncharacterized protein LOC224893 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT573084

    4. NM_001410546.1 → NP_001397475.1  uncharacterized protein LOC224893 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT573084

    5. NM_001410547.1 → NP_001397476.1  uncharacterized protein LOC224893 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT573084

    6. NM_001410548.1 → NP_001397477.1  uncharacterized protein LOC224893 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT573084

    7. NM_001410549.1 → NP_001397478.1  uncharacterized protein LOC224893 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT573084

    8. NM_001410550.1 → NP_001397479.1  uncharacterized protein LOC224893 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT573084

    9. NM_145490.5 → NP_663465.1  uncharacterized protein LOC224893 isoform 1

      See identical proteins and their annotated locations for NP_663465.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC154235, CT573084
      Consensus CDS
      CCDS37657.1
      UniProtKB/TrEMBL
      Q91VM8
      Related
      ENSMUSP00000053979.9, ENSMUST00000054780.10
      Conserved Domains (5) summary
      smart00349
      Location:4 → 45
      KRAB; krueppel associated box
      COG5048
      Location:369 → 502
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:401 → 421
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 41
      KRAB; KRAB box
      pfam13465
      Location:441 → 466
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56199093..56205935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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