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    Treml4 triggering receptor expressed on myeloid cells-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 224840, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Treml4provided by MGI
    Official Full Name
    triggering receptor expressed on myeloid cells-like 4provided by MGI
    Primary source
    MGI:MGI:1923239
    See related
    Ensembl:ENSMUSG00000051682 AllianceGenome:MGI:1923239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TLT4; IDCP1; TLT-4; Treml3; 5031403H21Rik
    Summary
    Predicted to enable signaling receptor activity. Involved in positive regulation of defense response to virus by host; positive regulation of toll-like receptor signaling pathway; and protein localization. Acts upstream of or within T cell antigen processing and presentation and phagocytosis, engulfment. Located in endoplasmic reticulum. Colocalizes with endosome membrane and lysosomal membrane. Orthologous to human TREML4 (triggering receptor expressed on myeloid cells like 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 17.3), lung adult (RPKM 2.7) and 5 other tissues See more
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    Genomic context

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    Location:
    17 C; 17 23.99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48571229..48582635)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48264200..48275607)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52308 Neighboring gene triggering receptor expressed on myeloid cells 1 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells 3 Neighboring gene STARR-positive B cell enhancer ABC_E9957 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48439578-48439845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48440299-48440452 Neighboring gene triggering receptor expressed on myeloid cells-like 2 Neighboring gene triggering receptor expressed on myeloid cells-like 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis. Nedeva C, et al. Nat Immunol, 2020 Dec. PMID 33020659
    2. TREML4 Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse. Gonzalez-Cotto M, et al. Front Immunol, 2020. PMID 32292401, Free PMC Article
    3. Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein. Hemmi H, et al. J Immunol, 2012 Feb 1. PMID 22210914, Free PMC Article
    4. A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells. Hemmi H, et al. J Immunol, 2009 Feb 1. PMID 19155473, Free PMC Article
    5. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Ramirez-Ortiz ZG, et al. Nat Immunol, 2015 May. PMID 25848864, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TREML4 Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse.
      Title: TREML4 Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse.
    2. positive regulator of TLR7 signaling that controls antiviral immunity and the development of autoimmunity
      Title: The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.
    3. Treml4 participates in Ag presentation in vivo
      Title: Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein.
    4. Treml4 associates with adaptor molecule DNAX activation protein 12 kDa (DAP12) and serves as a marker for select groups of both dendritic cells and macrophages.
      Title: A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of toll-like receptor 13 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of toll-like receptor 7 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of toll-like receptor 7 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of toll-like receptor 7 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of toll-like receptor 9 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    trem-like transcript 4 protein
    Names
    IG-like domain containing protein IDCP1c
    triggering receptor expressed on myeloid cells-like 3
    triggering receptor expressed on myeloid cells-like 3b
    triggering receptor expressed on myeloid cells-like protein 3
    triggering receptor expressed on myeloid cells-like protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033922.2 → NP_001029094.1  trem-like transcript 4 protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_001029094.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses alternate in-frame splice junctions at the 5' ends of two exons compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AC241601, AK077228, DQ186654
      Consensus CDS
      CCDS50141.1
      UniProtKB/Swiss-Prot
      Q3LRV9
      Related
      ENSMUSP00000119177.2, ENSMUST00000125426.8
      Conserved Domains (1) summary
      cd05716
      Location:35 → 124
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

    2. NM_001163795.1 → NP_001157267.1  trem-like transcript 4 protein isoform 3 precursor

      See identical proteins and their annotated locations for NP_001157267.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC241601, AK077228, AY465532
      Consensus CDS
      CCDS50139.1
      UniProtKB/TrEMBL
      D3YYN5
      Related
      ENSMUSP00000118772.2, ENSMUST00000154335.8
      Conserved Domains (1) summary
      cd05716
      Location:39 → 128
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

    3. NM_001163796.1 → NP_001157268.1  trem-like transcript 4 protein isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AC241601, AK077228, AY465532
      Consensus CDS
      CCDS50140.1
      UniProtKB/TrEMBL
      D3YY88
      Related
      ENSMUSP00000120550.2, ENSMUST00000136272.8
      Conserved Domains (1) summary
      cd05716
      Location:39 → 128
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

    4. NM_172623.2 → NP_766211.2  trem-like transcript 4 protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_766211.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 3.
      Source sequence(s)
      AC241601, AK077228, BC117091
      Consensus CDS
      CCDS28862.1
      UniProtKB/Swiss-Prot
      A6XA78, E9Q825, Q3LRV9, Q3LRW0
      Related
      ENSMUSP00000054121.8, ENSMUST00000059873.14
      Conserved Domains (1) summary
      cd05716
      Location:39 → 128
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48571229..48582635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524147.5 → XP_006524210.1  trem-like transcript 4 protein isoform X1

      Conserved Domains (1) summary
      cd05716
      Location:35 → 124
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

    2. XM_006524148.4 → XP_006524211.1  trem-like transcript 4 protein isoform X2

      UniProtKB/TrEMBL
      A0A0R4J1R6
      Conserved Domains (1) summary
      cd05716
      Location:39 → 128
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

    3. XM_006524149.4 → XP_006524212.1  trem-like transcript 4 protein isoform X3

      UniProtKB/TrEMBL
      A0A0R4J1R6
      Related
      ENSMUSP00000115290.2, ENSMUST00000153420.2
      Conserved Domains (1) summary
      cd05716
      Location:39 → 128
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3LRV9.1 GenPept UniProtKB/Swiss-Prot:Q3LRV9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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