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    Abcc10 ATP-binding cassette, sub-family C member 10 [ Mus musculus (house mouse) ]

    Gene ID: 224814, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Abcc10provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family C member 10provided by MGI
    Primary source
    MGI:MGI:2386976
    See related
    Ensembl:ENSMUSG00000032842 AllianceGenome:MGI:2386976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrp7; mFLJ00002
    Summary
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 18.2), colon adult (RPKM 18.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 C; 17 22.9 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46614146..46638954, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46303220..46328031, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tight junction associated protein 1 Neighboring gene predicted gene, 41588 Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene STARR-positive B cell enhancer ABC_E1943 Neighboring gene cDNA sequence BC040756 Neighboring gene zinc finger protein 318 Neighboring gene predicted gene 9706

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice. Otaibi AA, et al. Int J Mol Sci, 2022 Nov 10. PMID 36430292, Free PMC Article
    2. Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice. Hopper-Borge EA, et al. Cancer Res, 2011 May 15. PMID 21576088, Free PMC Article
    3. cDNA cloning and genomic organization of the murine MRP7, a new ATP-binding cassette transporter. Kao HH, et al. Gene, 2002 Mar 20. PMID 11943485
    4. Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1). Yang QS, et al. Biochim Biophys Acta, 2002 Apr 12. PMID 11997112
    5. Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines. Naramoto H, et al. Int J Oncol, 2007 Feb. PMID 17203221

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice.
      Title: ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice.
    2. Abcc10 is dispensable for health and viability and it is an endogenous resistance factor for taxanes, other natural product agents, and nucleoside analogues
      Title: Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice.
    3. MDR1 expression, MRP1 expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy; induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in salivary gland adenocarcinoma
      Title: Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type glutathione S-conjugate transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ABC-type transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ABC-type xenobiotic transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in leukotriene metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family C member 10
    Names
    ATP-binding cassette, sub-family C (CFTR/MRP), member 10
    multidrug resistance-associated protein 7
    NP_001334325.1
    NP_660122.1
    NP_733780.1
    XP_017172930.1
    XP_017172931.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347396.1 → NP_001334325.1  ATP-binding cassette sub-family C member 10 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AK133240, BC060644, BP757737, CT009572
      Consensus CDS
      CCDS84315.1
      UniProtKB/TrEMBL
      B9EKB9
      Related
      ENSMUSP00000038041.8, ENSMUST00000047970.14

    2. NM_145140.2 → NP_660122.1  ATP-binding cassette sub-family C member 10 isoform mrp7A

      See identical proteins and their annotated locations for NP_660122.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (mrp7A) encodes the shortest isoform (mrp7A).
      Source sequence(s)
      AF406642, CO042416
      Consensus CDS
      CCDS28825.1
      UniProtKB/TrEMBL
      B9EKB9
      Related
      ENSMUSP00000092895.4, ENSMUST00000095261.10
      Conserved Domains (4) summary
      cd03244
      Location:1212 → 1431
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:558 → 761
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:179 → 1437
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:921 → 1155
      ABC_membrane; ABC transporter transmembrane region

    3. NM_170680.2 → NP_733780.1  ATP-binding cassette sub-family C member 10 isoform mrp7B

      See identical proteins and their annotated locations for NP_733780.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (mrp7B) contains a distinct 5' UTR and 5' coding region, compared to variant mrp7A. This results in a distinct N-terminus and longer isoform (mrp7B) but maintains the same reading frame as isoform mrp7A.
      Source sequence(s)
      AC151275, AF417121, CO042416
      Consensus CDS
      CCDS50124.1
      UniProtKB/Swiss-Prot
      Q3TCQ0, Q3V0D1, Q8R4P9, Q8R4S1
      UniProtKB/TrEMBL
      B9EKB9
      Related
      ENSMUSP00000131843.2, ENSMUST00000167360.8
      Conserved Domains (4) summary
      cd03244
      Location:1253 → 1472
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:599 → 802
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:220 → 1478
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:962 → 1196
      ABC_membrane; ABC transporter transmembrane region

    RNA

    1. NR_182268.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      CT009572

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46614146..46638954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317442.2 → XP_017172931.1  ATP-binding cassette sub-family C member 10 isoform X2

      Conserved Domains (1) summary
      TIGR00957
      Location:2 → 851
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    2. XM_017317441.3 → XP_017172930.1  ATP-binding cassette sub-family C member 10 isoform X1

      Conserved Domains (4) summary
      TIGR00957
      Location:203 → 911
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd07346
      Location:887 → 910
      ABC_6TM_exporters; TM helix 1 [structural motif]
      cd18598
      Location:289 → 572
      ABC_6TM_MRP7_D1_like; Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated protein 7, and similar proteins
      cl38913
      Location:887 → 994
      ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters

    RNA

    1. XR_004939517.1 RNA Sequence

    2. XR_385318.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4P9.1 GenPept UniProtKB/Swiss-Prot:Q8R4P9

    Gene LinkOut

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