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    Marchf2 membrane associated ring-CH-type finger 2 [ Mus musculus (house mouse) ]

    Gene ID: 224703, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Marchf2provided by MGI
    Official Full Name
    membrane associated ring-CH-type finger 2provided by MGI
    Primary source
    MGI:MGI:1925915
    See related
    Ensembl:ENSMUSG00000079557 AllianceGenome:MGI:1925915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    March2; MARCH-II; 9530046H09Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within endocytosis. Predicted to be located in cytoplasmic vesicle; cytosol; and endoplasmic reticulum. Is expressed in several structures, including axial skeleton; bone; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human MARCHF2 (membrane associated ring-CH-type finger 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 31.0), liver E14 (RPKM 27.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 17.98 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33904666..33937651, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33685692..33718677, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42409 Neighboring gene PML-RAR alpha-regulated adaptor molecule 1 Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene STARR-positive B cell enhancer ABC_E10946 Neighboring gene STARR-positive B cell enhancer ABC_E7520 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E82 Neighboring gene RAB11B, member RAS oncogene family, opposite strand 1 Neighboring gene angiopoietin-like 4 Neighboring gene predicted gene, 53997

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9. Sandow JJ, et al. Proteomics, 2021 Jun. PMID 33945654
    2. The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation. Zeng LW, et al. Cell Mol Immunol, 2022 Oct. PMID 35982175, Free PMC Article
    3. Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2. Chathuranga K, et al. EMBO J, 2020 Nov 2. PMID 32935379, Free PMC Article
    4. MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors. Han SO, et al. J Cell Biol, 2012 Nov 26. PMID 23166351, Free PMC Article
    5. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation.
      Title: The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation.
    2. Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9.
      Title: Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9.
    3. Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.
      Title: Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7259

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antiviral innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of lysosomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF2
    Names
    E3 ubiquitin-protein ligase MARCH2
    RING finger protein 172
    RING-type E3 ubiquitin transferase MARCH2
    RING-type E3 ubiquitin transferase MARCHF2
    membrane-associated RING finger protein 2
    membrane-associated RING-CH protein II
    membrane-associated ring finger (C3HC4) 2
    NP_001239409.1
    NP_663461.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252480.1 → NP_001239409.1  E3 ubiquitin-protein ligase MARCHF2 isoform 2

      See identical proteins and their annotated locations for NP_001239409.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK079234, AV336582, CT030732
      Consensus CDS
      CCDS57064.1
      UniProtKB/Swiss-Prot
      Q8C4Q5, Q99M02
      UniProtKB/TrEMBL
      Q8BPS3
      Related
      ENSMUSP00000134220.2, ENSMUST00000172767.9
      Conserved Domains (2) summary
      pfam00558
      Location:173 → 224
      Vpu; Vpu protein
      cd16808
      Location:62 → 113
      RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)

    2. NM_145486.5 → NP_663461.2  E3 ubiquitin-protein ligase MARCHF2 isoform 1

      See identical proteins and their annotated locations for NP_663461.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK039778, AK040163, BF729651, CA324654, CT030732
      Consensus CDS
      CCDS28627.1
      UniProtKB/TrEMBL
      Q8BPS3, Q8CA25
      Related
      ENSMUSP00000065225.7, ENSMUST00000066121.13
      Conserved Domains (2) summary
      pfam00558
      Location:173 → 224
      Vpu; Vpu protein
      smart00744
      Location:63 → 110
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RNA

    1. NR_045522.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK040163, AK053434, BB634112, CT030732

    2. NR_045523.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK040163, CT030732
      Related
      ENSMUST00000172934.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33904666..33937651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99M02.1 GenPept UniProtKB/Swiss-Prot:Q99M02

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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