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    Slc26a8 solute carrier family 26, member 8 [ Mus musculus (house mouse) ]

    Gene ID: 224661, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc26a8provided by MGI
    Official Full Name
    solute carrier family 26, member 8provided by MGI
    Primary source
    MGI:MGI:2385046
    See related
    Ensembl:ENSMUSG00000036196 AllianceGenome:MGI:2385046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable anion transmembrane transporter activity. Predicted to be involved in chloride transport; oxalate transport; and sulfate transport. Predicted to act upstream of or within several processes, including ion transport; meiotic cell cycle; and spermatogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in embryo. Human ortholog(s) of this gene implicated in spermatogenic failure 3. Orthologous to human SLC26A8 (solute carrier family 26 member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 35.0) and cortex adult (RPKM 1.2) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 14.82 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28856757..28910242, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28637779..28691273, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene lipoma HMGIC fusion partner-like 5 Neighboring gene STARR-seq mESC enhancer starr_42224 Neighboring gene serine/arginine-rich protein specific kinase 1 Neighboring gene STARR-seq mESC enhancer starr_42228 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28828272-28828381 Neighboring gene mitogen-activated protein kinase 14 Neighboring gene G protein subunit gamma 5C Neighboring gene mitogen-activated protein kinase 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The heterozygous mutations of SLC26A8 are not the main actors for male infertility. Liu M, et al. Hum Mutat, 2022 May. PMID 35181959
    2. The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse. Touré A, et al. Hum Mol Genet, 2007 Aug 1. PMID 17517695
    3. The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation. Rode B, et al. Hum Mol Genet, 2012 Mar 15. PMID 22121115
    4. A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. Longo-Guess CM, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905332, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The heterozygous mutations of SLC26A8 are not the main actors for male infertility.
      Title: The heterozygous mutations of SLC26A8 are not the main actors for male infertility.
    2. Tat1 (Slc26A8) is a critical component of the sperm annulus that is essential for proper sperm tail differentiation and motility
      Title: The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38861

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxalate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate:chloride antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxalate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm annulus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    testis anion transporter 1
    Names
    anion exchange transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290320.2 → NP_001277249.1  testis anion transporter 1 isoform 1

      See identical proteins and their annotated locations for NP_001277249.1

      Status: VALIDATED

      Source sequence(s)
      AC170998
      Consensus CDS
      CCDS70779.1
      UniProtKB/Swiss-Prot
      Q8R0C3
      UniProtKB/TrEMBL
      A0A3B2WCZ8
      Related
      ENSMUSP00000110412.2, ENSMUST00000114764.8
      Conserved Domains (2) summary
      cd07042
      Location:719 → 778
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:76 → 582
      sulP; high affinity sulphate transporter 1

    2. NM_001410514.1 → NP_001397443.1  testis anion transporter 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC170998

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28856757..28910242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249692.2 → XP_030105552.1  testis anion transporter 1 isoform X6

      UniProtKB/TrEMBL
      A0A3B2WCZ8
      Related
      ENSMUSP00000156769.2, ENSMUST00000233249.2
      Conserved Domains (2) summary
      cd07042
      Location:664 → 723
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:76 → 527
      sulP; high affinity sulphate transporter 1

    2. XM_036160519.1 → XP_036016412.1  testis anion transporter 1 isoform X3

      UniProtKB/TrEMBL
      A0A3B2WCZ8
      Conserved Domains (2) summary
      cd07042
      Location:724 → 783
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:81 → 587
      sulP; high affinity sulphate transporter 1

    3. XM_011246387.4 → XP_011244689.1  testis anion transporter 1 isoform X4

      UniProtKB/TrEMBL
      A0A3B2WCZ8
      Conserved Domains (2) summary
      cd07042
      Location:692 → 751
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:104 → 555
      sulP; high affinity sulphate transporter 1

    4. XM_011246388.4 → XP_011244690.1  testis anion transporter 1 isoform X5

      Conserved Domains (1) summary
      TIGR00815
      Location:104 → 610
      sulP; high affinity sulphate transporter 1

    5. XM_011246385.4 → XP_011244687.1  testis anion transporter 1 isoform X2

      UniProtKB/TrEMBL
      A0A3B2WCZ8
      Conserved Domains (2) summary
      TIGR00815
      Location:104 → 610
      sulP; high affinity sulphate transporter 1
      cl00604
      Location:747 → 798
      STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors

    6. XM_011246384.4 → XP_011244686.1  testis anion transporter 1 isoform X1

      UniProtKB/TrEMBL
      A0A3B2WCZ8
      Conserved Domains (2) summary
      cd07042
      Location:747 → 806
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:104 → 610
      sulP; high affinity sulphate transporter 1

    7. XM_036160521.1 → XP_036016414.1  testis anion transporter 1 isoform X9

      Conserved Domains (2) summary
      cd07042
      Location:283 → 342
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      COG0659
      Location:2 → 141
      SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]

    8. XM_011246394.1 → XP_011244696.1  testis anion transporter 1 isoform X11

      Conserved Domains (2) summary
      cd07042
      Location:226 → 285
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:27 → 89
      sulP; high affinity sulphate transporter 1

    9. XM_011246389.4 → XP_011244691.1  testis anion transporter 1 isoform X7

      Conserved Domains (1) summary
      TIGR00815
      Location:104 → 610
      sulP; high affinity sulphate transporter 1

    10. XM_011246390.4 → XP_011244692.1  testis anion transporter 1 isoform X8

      Conserved Domains (1) summary
      TIGR00815
      Location:104 → 610
      sulP; high affinity sulphate transporter 1

    11. XM_011246391.3 → XP_011244693.1  testis anion transporter 1 isoform X10

      Conserved Domains (1) summary
      pfam00916
      Location:118 → 517
      Sulfate_transp; Sulfate permease family

    RNA

    1. XR_001782064.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_146076.1: Suppressed sequence

      Description
      NM_146076.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript, and the protein is short compared to homologs.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0C3.2 GenPept UniProtKB/Swiss-Prot:Q8R0C3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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