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    Zfp523 zinc finger protein 523 [ Mus musculus (house mouse) ]

    Gene ID: 224656, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp523provided by MGI
    Official Full Name
    zinc finger protein 523provided by MGI
    Primary source
    MGI:MGI:2687278
    See related
    Ensembl:ENSMUSG00000024220 AllianceGenome:MGI:2687278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf76; 2810027J07
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; limb mesenchyme; oocyte; and urinary system. Orthologous to human ZNF76 (zinc finger protein 76). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 32.4), adrenal adult (RPKM 23.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 14.63 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28396136..28424860)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28177196..28205886)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease 34 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42185 Neighboring gene STARR-positive B cell enhancer ABC_E4199 Neighboring gene t-complex protein 11 Neighboring gene VISTA enhancer mm1525 Neighboring gene signal peptide, CUB domain, EGF-like 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28344631-28344740 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28348857-28349040 Neighboring gene STARR-seq mESC enhancer starr_42195 Neighboring gene STARR-positive B cell enhancer ABC_E7505 Neighboring gene STARR-positive B cell enhancer ABC_E10940 Neighboring gene STARR-seq mESC enhancer starr_42199 Neighboring gene STARR-positive B cell enhancer ABC_E4200 Neighboring gene differentially expressed in FDCP 6 Neighboring gene peroxisome proliferator activator receptor delta Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28393851-28394218 Neighboring gene RIKEN cDNA 1810013A23 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28407203-28407312

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP. Prigge JR, et al. J Biol Chem, 2006 May 5. PMID 16522640, Free PMC Article
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of gene regulatory interplay between TBP, PIAS1, PIAS3, PIASx, PIASy, ZFP523, and transcription factors
      Title: Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC66570, MGC79196

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 76

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357995.2 → NP_001344924.1  zinc finger protein 76 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC126937
      Consensus CDS
      CCDS28573.1
      UniProtKB/Swiss-Prot
      Q6P9T2, Q8BMU0
      UniProtKB/TrEMBL
      A0A3B2W3I6
      Related
      ENSMUSP00000073226.3, ENSMUST00000073534.10
      Conserved Domains (2) summary
      COG5048
      Location:179 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:167 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001413647.1 → NP_001400576.1  zinc finger protein 76 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC126937
      UniProtKB/Swiss-Prot
      Q6P9T2, Q8BMU0
      Related
      ENSMUSP00000156638.2, ENSMUST00000233613.2

    3. NM_001413648.1 → NP_001400577.1  zinc finger protein 76 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126937

    4. NM_001413649.1 → NP_001400578.1  zinc finger protein 76 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC126937

    5. NM_172617.4 → NP_766205.1  zinc finger protein 76 isoform 1

      See identical proteins and their annotated locations for NP_766205.1

      Status: VALIDATED

      Source sequence(s)
      AC126937
      Consensus CDS
      CCDS28573.1
      UniProtKB/Swiss-Prot
      Q6P9T2, Q8BMU0
      UniProtKB/TrEMBL
      A0A3B2W3I6
      Related
      ENSMUSP00000002318.2, ENSMUST00000002318.8
      Conserved Domains (2) summary
      COG5048
      Location:179 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:167 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_182184.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126937
      Related
      ENSMUST00000233841.2

    2. NR_182185.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126937

    3. NR_182186.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126937

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28396136..28424860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249689.2 → XP_030105549.1  zinc finger protein 76 isoform X2

      Conserved Domains (2) summary
      COG5189
      Location:95 → 152
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:101 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_030249690.1 → XP_030105550.1  zinc finger protein 76 isoform X2

      Related
      ENSMUST00000145313.8
      Conserved Domains (2) summary
      COG5189
      Location:95 → 152
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:101 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMU0.1 GenPept UniProtKB/Swiss-Prot:Q8BMU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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