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    Zfp758 zinc finger protein 758 [ Mus musculus (house mouse) ]

    Gene ID: 224598, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp758provided by MGI
    Official Full Name
    zinc finger protein 758provided by MGI
    Primary source
    MGI:MGI:2385044
    See related
    Ensembl:ENSMUSG00000044501 AllianceGenome:MGI:2385044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body and nucleolus. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human ZNF300 (zinc finger protein 300). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 1.5), placenta adult (RPKM 0.9) and 25 other tissues See more
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    Genomic context

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    Location:
    17 A3.3; 17 11.4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (22580406..22612890)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (22361430..22393909)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52309 Neighboring gene zinc finger protein 994 Neighboring gene STARR-seq mESC enhancer starr_42025 Neighboring gene STARR-positive B cell enhancer ABC_E4195 Neighboring gene STARR-seq mESC enhancer starr_42027 Neighboring gene predicted gene 7072 Neighboring gene STARR-seq mESC enhancer starr_42028 Neighboring gene predicted gene, 53992 Neighboring gene STARR-positive B cell enhancer ABC_E5576 Neighboring gene STARR-seq mESC enhancer starr_42030 Neighboring gene zinc finger protein 944 Neighboring gene STARR-seq mESC enhancer starr_42031 Neighboring gene STARR-positive B cell enhancer ABC_E5577 Neighboring gene STARR-seq mESC enhancer starr_42032 Neighboring gene zinc finger protein 946 Neighboring gene STARR-seq mESC enhancer starr_42034 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC29357, MGC67807

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 758

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347330.1 → NP_001334259.1  zinc finger protein 758 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117244, BX515134
      Consensus CDS
      CCDS84277.1
      UniProtKB/TrEMBL
      E9QAA1
      Related
      ENSMUSP00000121288.2, ENSMUST00000149699.8

    2. NM_001357990.2 → NP_001344919.1  zinc finger protein 758 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117244
      Consensus CDS
      CCDS37470.1
      UniProtKB/TrEMBL
      E9Q462
      Related
      ENSMUSP00000113532.2, ENSMUST00000121315.2
      Conserved Domains (3) summary
      COG5048
      Location:203 → 525
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box

    3. NM_001410502.1 → NP_001397431.1  zinc finger protein 758 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117244
      UniProtKB/TrEMBL
      E9Q462

    4. NM_001410503.1 → NP_001397432.1  zinc finger protein 758 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117244

    5. NM_001410504.1 → NP_001397433.1  zinc finger protein 758 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117244

    6. NM_145484.2 → NP_663459.2  zinc finger protein 758 isoform 1

      See identical proteins and their annotated locations for NP_663459.2

      Status: VALIDATED

      Source sequence(s)
      AC117244, BC022203, BX515134
      Consensus CDS
      CCDS37470.1
      UniProtKB/TrEMBL
      E9Q462
      Related
      ENSMUSP00000086143.3, ENSMUST00000088765.9
      Conserved Domains (3) summary
      COG5048
      Location:203 → 525
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box

    RNA

    1. NR_177080.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117244

    2. NR_177081.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117244

    3. NR_177082.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117244

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      22580406..22612890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003952106.2 RNA Sequence

    2. XR_004939511.1 RNA Sequence

    3. XR_004939512.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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