Rbm11 RNA binding motif protein 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbm11provided by MGI
Official Full Name: RNA binding motif protein 11provided by MGI
Primary source: MGI:MGI:2447622
See related: Ensembl:ENSMUSG00000032940 AllianceGenome:MGI:2447622
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A330018F01
Summary: Enables poly(U) RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within cellular response to oxidative stress. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human RBM11 (RNA binding motif protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 13.3), testis adult (RPKM 1.0) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.1; 16 43.22 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (75389796..75399706)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (75592844..75602825)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Rbm11 (e-PCR), detects polymorphism
- UniSTS:259135

Rbm11 (e-PCR), detects polymorphism
- UniSTS:259652

Rbm11 (e-PCR), detects polymorphism
- UniSTS:479220

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(U) RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables poly(U) RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear speck	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: splicing regulator RBM11

Names: putative RNA-binding protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417063.1 → NP_001403992.1 splicing regulator RBM11 isoform 2

Status: VALIDATED

Source sequence(s)

AC166995
NM_001417067.1 → NP_001403996.1 splicing regulator RBM11 isoform 3

Status: VALIDATED

Source sequence(s)

AC166995
NM_001417069.1 → NP_001403998.1 splicing regulator RBM11 isoform 3

Status: VALIDATED

Source sequence(s)

AC166995
NM_198302.3 → NP_938044.1 splicing regulator RBM11 isoform 1

See identical proteins and their annotated locations for NP_938044.1

Status: VALIDATED

Source sequence(s)

AC166995

Consensus CDS

CCDS37377.1

UniProtKB/Swiss-Prot

D3Z0X9, Q80YT9, Q8BYK1

UniProtKB/TrEMBL

H9KUZ7

Related

ENSMUSP00000109891.2, ENSMUST00000114253.2

Conserved Domains (2) summary

COG0724
Location:5 → 139

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12593
Location:9 → 83

RRM_RBM11; RNA recognition motif in vertebrate RNA-binding protein 11 (RBM11)