Crybg3 beta-gamma crystallin domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crybg3provided by MGI
Official Full Name: beta-gamma crystallin domain containing 3provided by MGI
Primary source: MGI:MGI:2676311
See related: Ensembl:ENSMUSG00000022723 AllianceGenome:MGI:2676311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm9581; 5031404N19
Summary: Predicted to enable protein kinase A binding activity. Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Predicted to be part of protein-containing complex. Orthologous to human CRYBG3 (crystallin beta-gamma domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 6.1), bladder adult (RPKM 5.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C1.3; 16 34.83 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (59312451..59421410, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (59492088..59601047, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structure determined at 1.86 A demonstrates that the beta-gamma crystallin domain of Crybg3 resembles more closely the lens beta-gamma crystallins than the microbial crystallins do.
Title: Aggregation-prone near-native intermediate formation during unfolding of a structurally similar nonlenticular βγ-crystallin domain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI449204 (e-PCR)
- UniSTS:160581

AU022790 (e-PCR)
- UniSTS:209235

MHAa67d6.seq (e-PCR)
- UniSTS:125272

NoName (e-PCR)
- UniSTS:237525

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of eye lens	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lens development in camera-type eye	IBA Inferred from Biological aspect of Ancestor more info
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta/gamma crystallin domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174848.4 → NP_777273.3 beta/gamma crystallin domain-containing protein 3

Status: VALIDATED

Source sequence(s)

AC154473, AC154854

Consensus CDS

CCDS28258.2

UniProtKB/TrEMBL

A0A338P6N4

Related

ENSMUSP00000156047.2, ENSMUST00000172910.3

Conserved Domains (4) summary

COG1766
Location:1658 → 1840

FliF; Flagellar biosynthesis/type III secretory pathway M-ring protein FliF/YscJ [Cell motility, Intracellular trafficking, secretion, and vesicular transport]

cd00161
Location:2820 → 2949

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

pfam00030
Location:2460 → 2543

Crystall; Beta/Gamma crystallin

cl02528
Location:2390 → 2428

Crystall; Beta/Gamma crystallin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

59312451..59421410 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159903.1 → XP_036015796.1 beta/gamma crystallin domain-containing protein 3 isoform X1

Conserved Domains (3) summary

COG1766
Location:1568 → 1750

FliF; Flagellar biosynthesis/type III secretory pathway M-ring protein FliF/YscJ [Cell motility, Intracellular trafficking, secretion, and vesicular transport]

pfam00030
Location:2463 → 2546

Crystall; Beta/Gamma crystallin

pfam00652
Location:2731 → 2857

Ricin_B_lectin; Ricin-type beta-trefoil lectin domain