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    Wnt6 wingless-type MMTV integration site family, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 22420, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Wnt6provided by MGI
    Official Full Name
    wingless-type MMTV integration site family, member 6provided by MGI
    Primary source
    MGI:MGI:98960
    See related
    Ensembl:ENSMUSG00000033227 AllianceGenome:MGI:98960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wnt-6
    Summary
    Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including epithelial-mesenchymal cell signaling; nephron tubule morphogenesis; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human WNT6 (Wnt family member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary adult (RPKM 26.4), limb E14.5 (RPKM 9.9) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C4; 1 38.54 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74793499..74824481)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74754342..74785322)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1 Neighboring gene protein kinase, AMP-activated, gamma 3 non-catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_01342 Neighboring gene predicted gene 29539 Neighboring gene predicted gene, 32099 Neighboring gene STARR-seq mESC enhancer starr_01343 Neighboring gene wingless-type MMTV integration site family, member 10A Neighboring gene VISTA enhancer mm1017 Neighboring gene nuclear encoded tRNA glycine 3 (anticodon GCC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Wnt6 is expressed in granulomatous lesions of Mycobacterium tuberculosis-infected mice and is involved in macrophage differentiation and proliferation. Schaale K, et al. J Immunol, 2013 Nov 15. PMID 24123681
    2. Wnt6 is essential for stromal cell proliferation during decidualization in mice. Wang Q, et al. Biol Reprod, 2013 Jan. PMID 23175771
    3. Wnt6 induces the specification and epithelialization of F9 embryonal carcinoma cells to primitive endoderm. Krawetz R, et al. Cell Signal, 2008 Mar. PMID 18160257
    4. Wnt 6 regulates the epithelialisation process of the segmental plate mesoderm leading to somite formation. Schmidt C, et al. Dev Biol, 2004 Jul 1. PMID 15196961
    5. Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells. Bonnet C, et al. Sci Rep, 2021 Oct 22. PMID 34686698, Free PMC Article

    See all (152) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of TGFbeta1 and WNT6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells.
      Title: Role of TGFβ1 and WNT6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells.
    2. Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells.
      Title: Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells.
    3. WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.
      Title: WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.
    4. Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome.
      Title: Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome.
    5. Secreted Wnt6 binds to FZD4 to activate the canonical Wnt6 signaling pathway, which is upstream of ROCK1 and 14-3-3sigma, and that this is the cell signaling pathway underlying diabetes-associated centrosome amplification.
      Title: Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
    6. RNA pol III-mediated transcription positively regulates long non-coding RNA H19 and Wnt6 expression, established adipogenesis inhibitors.
      Title: Maf1 and Repression of RNA Polymerase III-Mediated Transcription Drive Adipocyte Differentiation.
    7. Wnt6 signals through the canonical pathway in renal epithelial cells as evidenced by increased phosphorylation of GSK3beta ), nuclear accumulation of beta-catenin and increased TCF/Lef transcriptional activity
      Title: Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.
    8. A negative feedback loop involving WNT6 and DKK1 attenuates canonical WNT6-beta-catenin signaling, thereby allowing teratocarcinoma cells to differentiate.
      Title: Frizzled gene expression and negative regulation of canonical WNT-β-catenin signaling in mouse F9 teratocarcinoma cells.
    9. Sertoli cells secrete Wnt6 as a paracrine signal for undifferentiated spermatogonia.
      Title: Paracrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the adult mouse testis.
    10. A novel role of Sfrp2 and Wnt6 in regulating the dynamic process of CPC proliferation and differentiation.
      Title: Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within axis specification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial-mesenchymal cell signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nephron tubule development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nephron tubule formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tooth mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein Wnt-6
    Names
    wingless-related MMTV integration site 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009526.3 → NP_033552.2  protein Wnt-6 precursor

      See identical proteins and their annotated locations for NP_033552.2

      Status: VALIDATED

      Source sequence(s)
      AK133954, AV303464, M89800
      Consensus CDS
      CCDS15056.1
      UniProtKB/Swiss-Prot
      P22727, Q80ZM9
      Related
      ENSMUSP00000006716.7, ENSMUST00000006716.8
      Conserved Domains (1) summary
      cd19338
      Location:34 → 364
      Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74793499..74824481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495887.4 → XP_006495950.1  protein Wnt-6 isoform X1

      See identical proteins and their annotated locations for XP_006495950.1

      UniProtKB/Swiss-Prot
      P22727, Q80ZM9
      Conserved Domains (1) summary
      cd19338
      Location:34 → 364
      Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

    2. XM_006495888.4 → XP_006495951.1  protein Wnt-6 isoform X1

      See identical proteins and their annotated locations for XP_006495951.1

      UniProtKB/Swiss-Prot
      P22727, Q80ZM9
      Conserved Domains (1) summary
      cd19338
      Location:34 → 364
      Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

    3. XM_006495889.3 → XP_006495952.1  protein Wnt-6 isoform X2

      Conserved Domains (1) summary
      cd19338
      Location:1 → 331
      Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22727.2 GenPept UniProtKB/Swiss-Prot:P22727

    Gene LinkOut

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