Cip2a cell proliferation regulating inhibitor of protein phosphatase 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cip2aprovided by MGI
Official Full Name: cell proliferation regulating inhibitor of protein phosphatase 2Aprovided by MGI
Primary source: MGI:MGI:2146335
See related: Ensembl:ENSMUSG00000033031 AllianceGenome:MGI:2146335
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kiaa1524; C330027C09Rik
Summary: Predicted to enable protein homodimerization activity. Acts upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Predicted to be located in cytosol and plasma membrane. Is expressed in brain subventricular zone; hindlimb interdigital region; skin; and telencephalon. Orthologous to human CIP2A (cellular inhibitor of PP2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 14.8), liver E14 (RPKM 13.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B5; 16 30.75 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (48814524..48840079)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (48994157..49019716)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes.
Title: Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes.
Oct4 reduction contributes to testicular injury of unilateral testicular torsion in mice model and apoptotic death of Sertoli cells through mediating CIP2A expression.
Title: Oct4 reduction contributes to testicular injury of unilateral testicular torsion in mice model and apoptotic death of Sertoli cells through mediating CIP2A expression.
CIP2A deficiency promotes depression-like behaviors in mice through inhibition of dendritic arborization.
Title: CIP2A deficiency promotes depression-like behaviors in mice through inhibition of dendritic arborization.
Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling.
Title: Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling.
ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease.
Title: ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease.
Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice.
Title: Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice.
CIP2A-mediated PP2A inhibition drives tau/APP hyperphosphorylation and increases APP beta-cleavage and Abeta production.
Title: CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.
that CIP2A-promoted astrogliosis induces synaptic degeneration and cognitive deficits in Alzheimer's disease
Title: CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits.
CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation in mouse oocytes
Title: CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation.
Knockdown of CIP2A by stable CIP2A siRNA transfection inhibited MDA-MB-231 cell proliferation, invasion, colony growth in vitro, and xenograft growth and metastasis in vivo of breast cancer in mice.
Title: Clinical significance of sCIP2A levels in breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU018569 (e-PCR)
- UniSTS:180909

RH125802 (e-PCR)
- UniSTS:162548

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in broken chromosome clustering	ISO Inferred from Sequence Orthology more info
involved_in chromosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein CIP2A

Names: cancerous inhibitor of PP2A; p90 autoantigen homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172616.2 → NP_766204.2 protein CIP2A

See identical proteins and their annotated locations for NP_766204.2

Status: VALIDATED

Source sequence(s)

AK049356, AK160639, AV113368, BY453073

Consensus CDS

CCDS49867.1

UniProtKB/Swiss-Prot

B2RQ25, Q69ZH6, Q7TPZ7, Q8BWY9

UniProtKB/TrEMBL

D3Z7B5

Related

ENSMUSP00000044714.6, ENSMUST00000048374.6

Conserved Domains (3) summary

COG1340
Location:631 → 879

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

pfam16046
Location:675 → 839

FAM76; FAM76 protein

cl23720
Location:810 → 893

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

48814524..48840079

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522091.5 → XP_006522154.1 protein CIP2A isoform X1

UniProtKB/TrEMBL

D3Z7B5

Conserved Domains (1) summary

COG1196
Location:499 → 731

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006522092.4 → XP_006522155.1 protein CIP2A isoform X2

Conserved Domains (1) summary

COG1196
Location:340 → 572

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]