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    Dzip3 DAZ interacting protein 3, zinc finger [ Mus musculus (house mouse) ]

    Gene ID: 224170, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dzip3provided by MGI
    Official Full Name
    DAZ interacting protein 3, zinc fingerprovided by MGI
    Primary source
    MGI:MGI:1917433
    See related
    Ensembl:ENSMUSG00000064061 AllianceGenome:MGI:1917433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2A-HUB; A230104G20; 2310047C04Rik; 6430549P11Rik
    Summary
    Predicted to enable several functions, including phosphatase binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in cytoplasm. Orthologous to human DZIP3 (DAZ interacting zinc finger protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 15.0), CNS E14 (RPKM 12.5) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dzip3 in Genome Data Viewer
    Location:
    16 B5; 16 30.75 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48744591..48814505, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (48924228..48994142, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene resistin like alpha Neighboring gene STARR-seq mESC enhancer starr_40961 Neighboring gene resistin like gamma Neighboring gene STARR-seq mESC enhancer starr_40962 Neighboring gene STARR-positive B cell enhancer mm9_chr16:48942004-48942304 Neighboring gene predicted gene, 22576 Neighboring gene STARR-seq mESC enhancer starr_40963 Neighboring gene STARR-seq mESC enhancer starr_40964 Neighboring gene cell proliferation regulating inhibitor of protein phosphatase 2A Neighboring gene myosin, heavy chain 15 Neighboring gene STARR-positive B cell enhancer mm9_chr16:49164447-49164748

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation. Inoue D, et al. Sci Rep, 2015 Nov 16. PMID 26568260, Free PMC Article
    2. Novel CARM1-Interacting Protein, DZIP3, Is a Transcriptional Coactivator of Estrogen Receptor-α. Purcell DJ, et al. Mol Endocrinol, 2015 Dec. PMID 26505218, Free PMC Article
    3. Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Zhou W, et al. Mol Cell, 2008 Jan 18. PMID 18206970, Free PMC Article
    4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dzip3, the E3 ligase of H2AK119, represses differentiation-inducible genes in mouse embryonic stem cells.
      Title: Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase DZIP3
    Names
    DAZ-interacting protein 3 homolog
    RING-type E3 ubiquitin transferase DZIP3
    NP_001103487.1
    NP_001343354.1
    NP_081617.1
    XP_017172456.1
    XP_030104951.1
    XP_030104952.1
    XP_030104953.1
    XP_030104954.1
    XP_036015793.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110017.2 → NP_001103487.1  E3 ubiquitin-protein ligase DZIP3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154447
      Consensus CDS
      CCDS49866.1
      UniProtKB/Swiss-Prot
      Q148V3, Q7TPV2, Q80TU4, Q8BYK7
      UniProtKB/TrEMBL
      E9QNZ2
      Related
      ENSMUSP00000113344.2, ENSMUST00000121869.8
      Conserved Domains (2) summary
      pfam12678
      Location:1143 → 1184
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:1144 → 1184
      zf-RING_2; Ring finger domain

    2. NM_001356425.1 → NP_001343354.1  E3 ubiquitin-protein ligase DZIP3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154447
      UniProtKB/Swiss-Prot
      Q148V3, Q7TPV2, Q80TU4, Q8BYK7
      Conserved Domains (2) summary
      cl17238
      Location:1143 → 1168
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl25732
      Location:744 → 931
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_027341.2 → NP_081617.1  E3 ubiquitin-protein ligase DZIP3 isoform 2

      See identical proteins and their annotated locations for NP_081617.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes an isoform (2) which is shorter than isoform 1.
      Source sequence(s)
      AK163763, BC117954, CJ122641
      Consensus CDS
      CCDS37353.1
      UniProtKB/Swiss-Prot
      Q148V3, Q7TPV2, Q80TU4, Q8BYK7
      Related
      ENSMUSP00000110161.2, ENSMUST00000114516.8
      Conserved Domains (2) summary
      pfam12678
      Location:937 → 978
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:938 → 978
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      48744591..48814505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316967.2 → XP_017172456.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:538 → 725
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl17238
      Location:937 → 962
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_036159900.1 → XP_036015793.1  E3 ubiquitin-protein ligase DZIP3 isoform X5

      Conserved Domains (3) summary
      COG1196
      Location:191 → 378
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5540
      Location:499 → 637
      COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd16460
      Location:589 → 631
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins

    3. XM_030249092.1 → XP_030104952.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

      Conserved Domains (4) summary
      COG1196
      Location:397 → 584
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5540
      Location:705 → 843
      COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd16460
      Location:795 → 837
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      pfam18738
      Location:74 → 217
      HEPN_DZIP3; DZIP3/ hRUL138-like HEPN

    4. XM_030249093.1 → XP_030104953.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

      Conserved Domains (4) summary
      COG1196
      Location:397 → 584
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5540
      Location:705 → 843
      COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd16460
      Location:795 → 837
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      pfam18738
      Location:74 → 217
      HEPN_DZIP3; DZIP3/ hRUL138-like HEPN

    5. XM_030249094.1 → XP_030104954.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

      Conserved Domains (3) summary
      COG1196
      Location:291 → 478
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5540
      Location:599 → 737
      COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd16460
      Location:689 → 731
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins

    6. XM_030249091.1 → XP_030104951.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

      Conserved Domains (4) summary
      COG1196
      Location:497 → 684
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5540
      Location:805 → 943
      COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd16460
      Location:895 → 937
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      pfam18738
      Location:174 → 317
      HEPN_DZIP3; DZIP3/ hRUL138-like HEPN

    RNA

    1. XR_001781815.2 RNA Sequence

    2. XR_001781814.2 RNA Sequence

    3. XR_003951784.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPV2.2 GenPept UniProtKB/Swiss-Prot:Q7TPV2

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