Wnt3 wingless-type MMTV integration site family, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt3provided by MGI
Official Full Name: wingless-type MMTV integration site family, member 3provided by MGI
Primary source: MGI:MGI:98955
See related: Ensembl:ENSMUSG00000000125 AllianceGenome:MGI:98955
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Int-4; Wnt-3
Summary: Enables protein domain specific binding activity. Involved in positive regulation of Wnt signaling pathway. Acts upstream of or within several processes, including axis specification; embryonic morphogenesis; and generation of neurons. Located in extracellular matrix. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; embryo ectoderm; and genitourinary system. Human ortholog(s) of this gene implicated in tetraamelia syndrome 1. Orthologous to human WNT3 (Wnt family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 13.8), limb E14.5 (RPKM 4.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 67.5 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (103665000..103708854)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (103774175..103818021)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC01023 Promotes the Hepatoblastoma Tumorigenesis via miR-378a-5p/WNT3 Axis.
Title: LINC01023 Promotes the Hepatoblastoma Tumorigenesis via miR-378a-5p/WNT3 Axis.
Transport and Secretion of the Wnt3 Ligand by Motor Neuron-like Cells and Developing Motor Neurons.
Title: Transport and Secretion of the Wnt3 Ligand by Motor Neuron-like Cells and Developing Motor Neurons.
Paneth cell-derived growth factors support tumorigenesis in the small intestine.
Title: Paneth cell-derived growth factors support tumorigenesis in the small intestine.
Expression of Wnt3, a morphogen of the Wnt/beta-catenin pathway, was higher in pubertal Sertoli cells relative to infant Sertoli cells.
Title: Defective Wnt3 expression by testicular Sertoli cells compromise male fertility.
Downregulation of Gata4 could restore the phenotype exhibited by Wnt3 downregulation in dorsal root ganglion neurons.
Title: Wnt3 and Gata4 regulate axon regeneration in adult mouse DRG neurons.
Here, we describe the culture protocol using Wnt-3a for successful maintenance of skin epithelial stem cells .
Title: Maintenance of Skin Epithelial Stem Cells by Wnt-3a In Vitro.
Study indicates essential roles for Wnt2 and Wnt3 in chronic restraint stress-induced depression-like behaviors and antidepressant.
Title: The antidepressant roles of Wnt2 and Wnt3 in stress-induced depression-like behaviors.
these results therefore highlight an unanticipated role for p53 family proteins in a regulatory network that integrates essential Wnt-Tcf and nodal-Smad inputs.
Title: The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.
stem-cell membranes constitute a reservoir for Wnt proteins, while Frizzled receptor turnover and 'plasma membrane dilution' through cell division shape the epithelial Wnt3 gradient
Title: Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.
timed secretion of wnt3 by ingrowing axons from the thalamus regulates the combinatorial composition of ribosomal proteins in developing neocortex. WNT3 further regulates the specificity of mRNA translation and development of neurons and oligodendrocytes.
Title: Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt3 (e-PCR), detects polymorphism
- UniSTS:465419

Wnt3 (e-PCR), detects polymorphism
- UniSTS:526099

Wnt3 (e-PCR), detects polymorphism
- UniSTS:471323

Wnt3 (e-PCR), detects polymorphism
- UniSTS:527137

Wnt3 (e-PCR), detects polymorphism
- UniSTS:497473

M32502 (e-PCR)
- UniSTS:180344

PMC124275P4 (e-PCR)
- UniSTS:270462

Wnt3 (e-PCR), detects polymorphism
- UniSTS:144776

Wnt3 (e-PCR), detects polymorphism
- UniSTS:144777

Wnt3 (e-PCR), detects polymorphism
- UniSTS:516492

GDB:196138 (e-PCR)
- UniSTS:155819

PMC195987P1 (e-PCR)
- UniSTS:271790

Wnt3 (e-PCR), detects polymorphism
- UniSTS:507317

Wnt3 (e-PCR), detects polymorphism
- UniSTS:532699

Wnt3 (e-PCR), detects polymorphism
- UniSTS:508413

Wnt3 (e-PCR), detects polymorphism
- UniSTS:508414

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Spemann organizer formation at the anterior end of the primitive streak	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic forelimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hindlimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gamete generation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within head morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in limb bud formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midbrain dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of collateral sprouting in absence of injury	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in stem cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proto-oncogene Wnt-3

Names: proto-oncogene Int-4; proto-oncogene protein Wnt-3; wingless-related MMTV integration site 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009521.3 → NP_033547.1 proto-oncogene Wnt-3 precursor

See identical proteins and their annotated locations for NP_033547.1

Status: VALIDATED

Source sequence(s)

AL596108

Consensus CDS

CCDS25523.1

UniProtKB/Swiss-Prot

P17553

UniProtKB/TrEMBL

A2A649, Q8BLT2

Related

ENSMUSP00000000127.6, ENSMUST00000000127.6

Conserved Domains (1) summary

cd19335
Location:42 → 355

Wnt_Wnt3_Wnt3a; Wnt domain found in proto-oncogene Wnt-3 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

103665000..103708854

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533168.1 → XP_006533231.1 proto-oncogene Wnt-3 isoform X1

Conserved Domains (1) summary

cl38924
Location:2 → 250

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family