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    Nrros negative regulator of reactive oxygen species [ Mus musculus (house mouse) ]

    Gene ID: 224109, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Nrrosprovided by MGI
    Official Full Name
    negative regulator of reactive oxygen speciesprovided by MGI
    Primary source
    MGI:MGI:2445095
    See related
    Ensembl:ENSMUSG00000052384 AllianceGenome:MGI:2445095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrcc33; Lrrc33; E430025L02Rik
    Summary
    Enables transforming growth factor beta binding activity. Involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Located in cell surface and endoplasmic reticulum. Is expressed in embryo and thymus primordium. Orthologous to human NRROS (negative regulator of reactive oxygen species). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 34.1), thymus adult (RPKM 29.9) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B2; 16 22.4 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31961603..31984412, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32142785..32165594, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4164 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32107830-32107983 Neighboring gene STARR-positive B cell enhancer ABC_E4165 Neighboring gene centrosomal protein 19 Neighboring gene STARR-seq mESC enhancer starr_40643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32130316-32130510 Neighboring gene STARR-positive B cell enhancer ABC_E7441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32177054-32177400 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32177409-32177592 Neighboring gene STARR-seq mESC enhancer starr_40648 Neighboring gene brain expressed family member 6 Neighboring gene STARR-seq mESC enhancer starr_40649 Neighboring gene F-box protein 45 Neighboring gene predicted gene, 25848

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NRROS Negatively Regulates Osteoclast Differentiation by Inhibiting RANKL-Mediated NF-N:B and Reactive Oxygen Species Pathways. Kim JH, et al. Mol Cells, 2015 Oct. PMID 26442864, Free PMC Article
    2. Biallelic mutations in NRROS cause an early onset lethal microgliopathy. Smith C, et al. Acta Neuropathol, 2020 May. PMID 32100099, Free PMC Article
    3. Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors. Su X, et al. J Leukoc Biol, 2014 Jul. PMID 24550525
    4. Mice deficient in NRROS show abnormal microglial development and neurological disorders. Wong K, et al. Nat Immunol, 2017 Jun. PMID 28459434
    5. A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System. Qin Y, et al. Cell, 2018 Jun 28. PMID 29909984, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biallelic mutations in NRROS cause an early onset lethal microgliopathy.
      Title: Biallelic mutations in NRROS cause an early onset lethal microgliopathy.
    2. NRROS-deficient (Nrros(-/-)) mice show defects in motor functions and die before 6 months of age. Nrros(-/-) mice display astrogliosis and lack normal CD11b(hi)CD45(lo) microglia, but they show no detectable demyelination or neuronal loss. perivascular macrophage-like myeloid cells populate the Nrros(-/-) CNS. Cx3cr1-driven deletion of Nrros shows its crucial role in microglial establishment during early embryonic stages.
      Title: Mice deficient in NRROS show abnormal microglial development and neurological disorders.
    3. this study presents NRROS as a novel negative regulator of RANKL-induced osteoclastogenesis.
      Title: NRROS Negatively Regulates Osteoclast Differentiation by Inhibiting RANKL-Mediated NF-N:B and Reactive Oxygen Species Pathways.
    4. results suggest that LRRC33 and TLRs may form a negative-feedback loop, which is important for the maintenance of immune homeostasis.
      Title: Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors.
    5. NRROS provides a hitherto undefined mechanism for regulating ROS production--one that enables phagocytes to produce higher amounts of ROS, if required to control invading pathogens, while minimizing unwanted collateral tissue damage
      Title: NRROS negatively regulates reactive oxygen species during host defence and autoimmunity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC36838

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transforming growth factor beta binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microglia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sequestering of TGFbeta in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in superoxide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in superoxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transforming growth factor beta activator LRRC33
    Names
    leucine rich repeat containing 33
    leucine-rich repeat-containing protein 33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347181.1 → NP_001334110.1  transforming growth factor beta activator LRRC33 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC135962, BG230063
      Consensus CDS
      CCDS84220.1
      UniProtKB/Swiss-Prot
      Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
      UniProtKB/TrEMBL
      A0A338P6E7
      Related
      ENSMUSP00000097571.5, ENSMUST00000099991.11
      Conserved Domains (3) summary
      PLN00113
      Location:60 → 439
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:330 → 353
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:157 → 217
      LRR_8; Leucine rich repeat

    2. NM_001347182.1 → NP_001334111.1  transforming growth factor beta activator LRRC33 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC135962, BG230063
      Consensus CDS
      CCDS84221.1
      UniProtKB/TrEMBL
      A0A338P6E7
      Related
      ENSMUSP00000110819.4, ENSMUST00000115165.10

    3. NM_146069.5 → NP_666181.3  transforming growth factor beta activator LRRC33 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (2).
      Source sequence(s)
      AC135962, AK084858, BG230063, BY194080
      Consensus CDS
      CCDS84220.1
      UniProtKB/Swiss-Prot
      Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
      UniProtKB/TrEMBL
      A0A338P6E7
      Related
      ENSMUSP00000119349.2, ENSMUST00000143682.8
      Conserved Domains (3) summary
      PLN00113
      Location:60 → 439
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:330 → 353
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:157 → 217
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      31961603..31984412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522075.1 → XP_006522138.1  transforming growth factor beta activator LRRC33 isoform X1

      See identical proteins and their annotated locations for XP_006522138.1

      UniProtKB/Swiss-Prot
      Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
      UniProtKB/TrEMBL
      A0A338P6E7
      Conserved Domains (3) summary
      PLN00113
      Location:60 → 439
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:330 → 353
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:157 → 217
      LRR_8; Leucine rich repeat

    2. XM_006522074.4 → XP_006522137.1  transforming growth factor beta activator LRRC33 isoform X1

      See identical proteins and their annotated locations for XP_006522137.1

      UniProtKB/Swiss-Prot
      Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
      UniProtKB/TrEMBL
      A0A338P6E7
      Conserved Domains (3) summary
      PLN00113
      Location:60 → 439
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:330 → 353
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:157 → 217
      LRR_8; Leucine rich repeat

    3. XM_006522077.4 → XP_006522140.1  transforming growth factor beta activator LRRC33 isoform X1

      See identical proteins and their annotated locations for XP_006522140.1

      UniProtKB/Swiss-Prot
      Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
      UniProtKB/TrEMBL
      A0A338P6E7
      Conserved Domains (3) summary
      PLN00113
      Location:60 → 439
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:330 → 353
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:157 → 217
      LRR_8; Leucine rich repeat

    4. XM_017316962.3 → XP_017172451.1  transforming growth factor beta activator LRRC33 isoform X1

      UniProtKB/Swiss-Prot
      Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
      UniProtKB/TrEMBL
      A0A338P6E7
      Conserved Domains (3) summary
      PLN00113
      Location:60 → 439
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:330 → 353
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:157 → 217
      LRR_8; Leucine rich repeat

    5. XM_036159896.1 → XP_036015789.1  transforming growth factor beta activator LRRC33 isoform X1

      UniProtKB/Swiss-Prot
      Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
      UniProtKB/TrEMBL
      A0A338P6E7
      Conserved Domains (3) summary
      PLN00113
      Location:60 → 439
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:330 → 353
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:157 → 217
      LRR_8; Leucine rich repeat

    6. XM_006522076.4 → XP_006522139.1  transforming growth factor beta activator LRRC33 isoform X1

      See identical proteins and their annotated locations for XP_006522139.1

      UniProtKB/Swiss-Prot
      Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
      UniProtKB/TrEMBL
      A0A338P6E7
      Conserved Domains (3) summary
      PLN00113
      Location:60 → 439
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:330 → 353
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:157 → 217
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMT4.2 GenPept UniProtKB/Swiss-Prot:Q8BMT4

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