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    Scarf2 scavenger receptor class F, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 224024, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Scarf2provided by MGI
    Official Full Name
    scavenger receptor class F, member 2provided by MGI
    Primary source
    MGI:MGI:1858430
    See related
    Ensembl:ENSMUSG00000012017 AllianceGenome:MGI:1858430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NSR1; Srec2; Scatf1; SrecII; SREC-II; SRECRP-1
    Summary
    Enables scavenger receptor activity. Acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain; metanephros; skin; thoracic segment skeleton; and trachea. Human ortholog(s) of this gene implicated in Van den Ende-Gupta syndrome. Orthologous to human SCARF2 (scavenger receptor class F member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 105.4), ovary adult (RPKM 99.7) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A3; 16 11.03 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17615146..17626158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17797282..17808294)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene biorientation of chromosomes in cell division 1, pseudogene Neighboring gene kelch-like 22 Neighboring gene VISTA enhancer mm1629 Neighboring gene zinc finger protein 520, pseudogene Neighboring gene STARR-seq mESC enhancer starr_40262 Neighboring gene family with sequence similarity 246 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. Berwin B, et al. J Biol Chem, 2004 Dec 3. PMID 15371419
    2. Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide. Tamura Y, et al. J Biol Chem, 2004 Jul 23. PMID 15145948
    3. SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain. Ishii J, et al. J Biol Chem, 2002 Oct 18. PMID 12154095
    4. Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance. Bildsoe H, et al. Dev Biol, 2016 Oct 1. PMID 27546376
    5. Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2. Lund J, et al. Genomics, 2000 Feb 1. PMID 10704284

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. binds to SRECI and has a similar tissue distribution pattern
      Title: SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain.
    2. SREC-I is a type F scavenger receptor and an endocytic receptor for calreticulin
      Title: SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin.
    3. role of scavenger receptor expressed by endothelial cells I (SREC-I) in the uptake of modified lipoproteins as well as in the development of atherosclerosis
      Title: Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables scavenger receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    scavenger receptor class F member 2
    Names
    scavenger receptor expressed by endothelial cells 2 (acetyl LDL receptor like)
    scavenger receptor type F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153790.3 → NP_722485.1  scavenger receptor class F member 2 precursor

      See identical proteins and their annotated locations for NP_722485.1

      Status: VALIDATED

      Source sequence(s)
      AC078895, AF522197, BC059226
      Consensus CDS
      CCDS28010.1
      UniProtKB/Swiss-Prot
      P59222
      UniProtKB/TrEMBL
      Q58A84
      Related
      ENSMUSP00000012161.4, ENSMUST00000012161.5
      Conserved Domains (1) summary
      PRK12798
      Location:715 → 832
      PRK12798; chemotaxis protein; Reviewed

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17615146..17626158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159884.1 → XP_036015777.1  scavenger receptor class F member 2 isoform X1

      Related
      ENSMUST00000231329.2
      Conserved Domains (3) summary
      PHA03247
      Location:683 → 838
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:526 → 836
      PHA03307; transcriptional regulator ICP4; Provisional
      NF033759
      Location:74 → 431
      exchanger_TraA; outer membrane exchange protein TraA

    2. XM_036159886.1 → XP_036015779.1  scavenger receptor class F member 2 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:457 → 612
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:300 → 610
      PHA03307; transcriptional regulator ICP4; Provisional
      NF033759
      Location:6 → 205
      exchanger_TraA; outer membrane exchange protein TraA

    3. XM_036159885.1 → XP_036015778.1  scavenger receptor class F member 2 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:457 → 612
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:300 → 610
      PHA03307; transcriptional regulator ICP4; Provisional
      NF033759
      Location:6 → 205
      exchanger_TraA; outer membrane exchange protein TraA
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59222.1 GenPept UniProtKB/Swiss-Prot:P59222

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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