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    Klhl22 kelch-like 22 [ Mus musculus (house mouse) ]

    Gene ID: 224023, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Klhl22provided by MGI
    Official Full Name
    kelch-like 22provided by MGI
    Primary source
    MGI:MGI:1337995
    See related
    Ensembl:ENSMUSG00000022750 AllianceGenome:MGI:1337995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kelchl; 2610318I18Rik
    Summary
    Predicted to enable 14-3-3 protein binding activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Predicted to be located in several cellular components, including cytosol; intercellular bridge; and microtubule cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and microtubule cytoskeleton. Predicted to colocalize with lysosome and nucleus. Orthologous to human KLHL22 (kelch like family member 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 28.6), ovary adult (RPKM 22.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A3; 16 11.01 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17577485..17611246)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17759621..17793382)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene copy 8 Neighboring gene biorientation of chromosomes in cell division 1, pseudogene Neighboring gene scavenger receptor class F, member 2 Neighboring gene VISTA enhancer mm1629 Neighboring gene zinc finger protein 520, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression. Zhou XA, et al. Proc Natl Acad Sci U S A, 2020 Nov 10. PMID 33109719, Free PMC Article
    2. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Chen J, et al. Nature, 2018 May. PMID 29769719
    3. Analysis of cDNA sequences from mouse testis. Kerr SM, et al. Mamm Genome, 1994 Sep. PMID 8000140
    4. Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development. Kong X, et al. Development, 2022 Dec 15. PMID 36440598, Free PMC Article
    5. Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2. Lund J, et al. Genomics, 2000 Feb 1. PMID 10704284

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
      Title: Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in polar microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in polar microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359068.1 → NP_001345997.1  kelch-like protein 22 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC087802
      Consensus CDS
      CCDS49783.1
      UniProtKB/Swiss-Prot
      D3YW27, Q8BT13, Q99JN2
      Related
      ENSMUSP00000112412.2, ENSMUST00000120488.3
      Conserved Domains (4) summary
      PHA03098
      Location:52 → 592
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:340 → 385
      Kelch; KELCH repeat [structural motif]
      cd18251
      Location:27 → 151
      BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)
      cd18461
      Location:147 → 250
      BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

    2. NM_001379022.1 → NP_001365951.1  kelch-like protein 22 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087802
      UniProtKB/Swiss-Prot
      D3YW27, Q8BT13, Q99JN2
      Conserved Domains (4) summary
      PHA03098
      Location:52 → 592
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:340 → 385
      Kelch; KELCH repeat [structural motif]
      cd18251
      Location:27 → 151
      BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)
      cd18461
      Location:147 → 250
      BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

    3. NM_001379023.1 → NP_001365952.1  kelch-like protein 22 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087802
      UniProtKB/Swiss-Prot
      D3YW27, Q8BT13, Q99JN2
      Conserved Domains (4) summary
      PHA03098
      Location:52 → 592
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:340 → 385
      Kelch; KELCH repeat [structural motif]
      cd18251
      Location:27 → 151
      BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)
      cd18461
      Location:147 → 250
      BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

    4. NM_001379024.1 → NP_001365953.1  kelch-like protein 22 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087802
      Conserved Domains (4) summary
      PHA03098
      Location:71 → 611
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:359 → 404
      Kelch; KELCH repeat [structural motif]
      cd18251
      Location:46 → 170
      BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)
      cd18461
      Location:166 → 269
      BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

    5. NM_001379025.1 → NP_001365954.1  kelch-like protein 22 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087802, AK030669
      UniProtKB/TrEMBL
      Q8CDC1
      Conserved Domains (3) summary
      sd00038
      Location:294 → 335
      Kelch; KELCH repeat [structural motif]
      cd18461
      Location:147 → 250
      BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)
      cl38908
      Location:27 → 151
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    6. NM_001379026.1 → NP_001365955.1  kelch-like protein 22 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087802
      UniProtKB/TrEMBL
      Q8CDC1
      Conserved Domains (3) summary
      sd00038
      Location:294 → 335
      Kelch; KELCH repeat [structural motif]
      cd18461
      Location:147 → 250
      BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)
      cl38908
      Location:27 → 151
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    7. NM_145479.4 → NP_663454.3  kelch-like protein 22 isoform 1

      See identical proteins and their annotated locations for NP_663454.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI845204, AK143514, CJ159851
      Consensus CDS
      CCDS49783.1
      UniProtKB/Swiss-Prot
      D3YW27, Q8BT13, Q99JN2
      Related
      ENSMUSP00000127227.2, ENSMUST00000165790.9
      Conserved Domains (4) summary
      PHA03098
      Location:52 → 592
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:340 → 385
      Kelch; KELCH repeat [structural motif]
      cd18251
      Location:27 → 151
      BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)
      cd18461
      Location:147 → 250
      BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

    RNA

    1. NR_166418.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087802

    2. NR_166419.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087802

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17577485..17611246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JN2.1 GenPept UniProtKB/Swiss-Prot:Q99JN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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