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    Krt79 keratin 79 [ Mus musculus (house mouse) ]

    Gene ID: 223917, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Krt79provided by MGI
    Official Full Name
    keratin 79provided by MGI
    Primary source
    MGI:MGI:2385030
    See related
    Ensembl:ENSMUSG00000061397 AllianceGenome:MGI:2385030
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable enzyme binding activity. Predicted to be located in keratin filament. Is expressed in vibrissa. Orthologous to human KRT79 (keratin 79). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 6.7), genital fat pad adult (RPKM 2.5) and 6 other tissues See more
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    Genomic context

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    See Krt79 in Genome Data Viewer
    Location:
    15 F2; 15 57.14 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101837767..101848759, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101929332..101940324, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 76 Neighboring gene keratin 4 Neighboring gene keratin 78 Neighboring gene keratin 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Keratin 79 is a PPARA target that is highly expressed by liver damage. Kim D, et al. Biochem Biophys Res Commun, 2023 Apr 2. PMID 36796223, Free PMC Article
    2. Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct. Swanson JB, et al. Exp Dermatol, 2019 Apr. PMID 30033638, Free PMC Article
    3. Hair Follicle Terminal Differentiation Is Orchestrated by Distinct Early and Late Matrix Progenitors. Mesler AL, et al. Cell Rep, 2017 Apr 25. PMID 28445731, Free PMC Article
    4. Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin. Veniaminova NA, et al. Dev Cell, 2019 Nov 4. PMID 31564613, Free PMC Article
    5. Bleomycin-induced pulmonary fibrosis susceptibility genes in AcB/BcA recombinant congenic mice. Lemay AM, et al. Physiol Genomics, 2005 Sep 21. PMID 16179420

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. migratory keratinocytes express keratin 79 and stream out of the hair germ and into the epidermis prior to lumen formation in the embryo.
      Title: Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC36907

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type II cytoskeletal 79
    Names
    CK-79
    K79
    cytokeratin-79
    type-II keratin Kb38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146063.1 → NP_666175.1  keratin, type II cytoskeletal 79

      See identical proteins and their annotated locations for NP_666175.1

      Status: PROVISIONAL

      Source sequence(s)
      BC031593
      Consensus CDS
      CCDS27867.1
      UniProtKB/Swiss-Prot
      Q8K2E4, Q8VED5
      Related
      ENSMUSP00000023799.8, ENSMUST00000023799.8
      Conserved Domains (2) summary
      pfam00038
      Location:138 → 452
      Filament; Intermediate filament protein
      pfam16208
      Location:62 → 135
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101837767..101848759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VED5.2 GenPept UniProtKB/Swiss-Prot:Q8VED5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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