Wee1 WEE 1 homolog 1 (S. pombe) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wee1provided by MGI
Official Full Name: WEE 1 homolog 1 (S. pombe)provided by MGI
Primary source: MGI:MGI:103075
See related: Ensembl:ENSMUSG00000031016 AllianceGenome:MGI:103075
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wee1A
Summary: Enables protein kinase activity. Acts upstream of or within several processes, including establishment of cell polarity; neuron projection morphogenesis; and peptidyl-tyrosine phosphorylation. Located in cytoplasm. Is expressed in several structures, including 8-cell stage embryo; alimentary system; blastocyst; brain ventricular layer; and inferior colliculus. Orthologous to human WEE1 (WEE1 G2 checkpoint kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 12.3), placenta adult (RPKM 11.4) and 27 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7 E3; 7 57.7 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (109721266..109742506)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (110122059..110143299)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autophagy modulates the stability of Wee1 and cell cycle G2/M transition.
Title: Autophagy modulates the stability of Wee1 and cell cycle G2/M transition.
Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-gammaH2AX-MDC1.
Title: Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1.
WEE1 promotes endometriosis via the Wnt/beta-catenin signaling pathway.
Title: WEE1 promotes endometriosis via the Wnt/β-catenin signaling pathway.
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
Title: WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
Morphine significantly downregulated the expression of miRNA-219-5p, which targets WEE1 to suppress Tyr15 expressions and activate Cdc2, thus inhibiting the morphine-induced macrophage apoptosis.
Title: MicroRNA-219-5p Inhibits Morphine-Induced Apoptosis by Targeting Key Cell Cycle Regulator WEE1.
Results revealed that WEE1 is indispensable for maintaining genomic stability and it functions as a haploinsufficient tumor suppressor.
Title: WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis.
Wee1 is directly or indirectly involved in the mechanism of the circadian rhythm-dependent changes in docetaxel-induced intestinal damage.
Title: Involvement of Wee1 in the circadian rhythm-dependent intestinal damage induced by docetaxel.
The induction of Wee1 under hypoxia was confirmed both at the mRNA and protein levels.
Title: Hypoxia induces Wee1 expression and attenuates hydrogen peroxide-induced endothelial damage in MS1 cells.
In this study, we found that the chromosomal wee1 gene is also down-regulated by KLF3.
Title: Mouse Wee1 gene is repressed by Krüppel-like factor 3 (KLF3) via interaction with multiple upstream elements.
The regulation of Wee1 by SadA and SadB kinases is essential for the differentiation of polarized neurons.
Title: Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1)
Gene trapped (1)
Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:238022

MARC_17360-17361:1021651098:1 (e-PCR)
- UniSTS:268284

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: wee1-like protein kinase

Names: WEE1 tyrosine kinase; wee1A kinase

NP_001341987.1

EC 2.7.10.2

NP_033542.2

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355058.1 → NP_001341987.1 wee1-like protein kinase isoform 2

Status: VALIDATED

Source sequence(s)

AC147244

Conserved Domains (1) summary

cl21453
Location:292 → 518

PKc_like; Protein Kinases, catalytic domain
NM_009516.3 → NP_033542.2 wee1-like protein kinase isoform 1

See identical proteins and their annotated locations for NP_033542.2

Status: VALIDATED

Source sequence(s)

AK011212, AK039572, BY631896, CJ130595

Consensus CDS

CCDS21743.1

UniProtKB/Swiss-Prot

P47810, Q9EPL7

Related

ENSMUSP00000033326.9, ENSMUST00000033326.10

Conserved Domains (2) summary

cd14138
Location:292 → 567

PTKc_Wee1a; Catalytic domain of the Protein Tyrosine Kinase, Wee1a

pfam00069
Location:298 → 568

Pkinase; Protein kinase domain