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    Senp1 SUMO1/sentrin specific peptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 223870, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Senp1provided by MGI
    Official Full Name
    SUMO1/sentrin specific peptidase 1provided by MGI
    Primary source
    MGI:MGI:2445054
    See related
    Ensembl:ENSMUSG00000033075 AllianceGenome:MGI:2445054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    suPr-2; D15Ertd528e; 2310046A20Rik; E330036L07Rik
    Summary
    Enables SUMO-specific isopeptidase activity. Acts upstream of or within negative regulation of proteasomal ubiquitin-dependent protein catabolic process; protein desumoylation; and regulation of definitive erythrocyte differentiation. Predicted to be located in focal adhesion; nuclear membrane; and nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo and heart. Used to study type 1 diabetes mellitus. Orthologous to human SENP1 (SUMO specific peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.4), thymus adult (RPKM 9.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 F1; 15 54.04 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97936625..97991625, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98038744..98093569, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene collagen, type II, alpha 1 Neighboring gene predicted gene, 46536 Neighboring gene predicted gene, 41395 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97898039-97898148 Neighboring gene STARR-seq mESC enhancer starr_39649 Neighboring gene predicted gene, 25668 Neighboring gene STARR-positive B cell enhancer ABC_E10879 Neighboring gene STARR-positive B cell enhancer ABC_E5514 Neighboring gene STARR-seq mESC enhancer starr_39650 Neighboring gene STARR-seq mESC enhancer starr_39651 Neighboring gene phosphofructokinase, muscle Neighboring gene STARR-seq mESC enhancer starr_39652 Neighboring gene STARR-seq mESC enhancer starr_39654 Neighboring gene ankyrin repeat and SOCS box-containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E5515 Neighboring gene coiled-coil domain containing 184

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway. Wang H, et al. Int Immunopharmacol, 2023 Jun. PMID 37137262
    2. SENP1 protects cisplatin-induced AKI by attenuating apoptosis through regulation of HIF-1α. Wang L, et al. Exp Cell Res, 2022 Oct 1. PMID 35839862
    3. SENP1 regulates the transformation of lung resident mesenchymal stem cells and is associated with idiopathic pulmonary fibrosis progression. Sun W, et al. Cell Commun Signal, 2022 Jul 14. PMID 35836260, Free PMC Article
    4. Ginkgolic acid improves bleomycin-induced pulmonary fibrosis by inhibiting SMAD4 SUMOylation. Yu L, et al. Oxid Med Cell Longev, 2022. PMID 35707278, Free PMC Article
    5. Role of pericyte-derived SENP1 in neuronal injury after brain ischemia. Sun M, et al. CNS Neurosci Ther, 2020 Aug. PMID 32495523, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SENP1 attenuates hypoxia-reoxygenation injury in liver sinusoid endothelial cells by relying on the HIF-1alpha signaling pathway.
      Title: SENP1 attenuates hypoxia‑reoxygenation injury in liver sinusoid endothelial cells by relying on the HIF‑1α signaling pathway.
    2. A role and mechanism for redox sensing by SENP1 in beta-cell responses to high fat feeding.
      Title: A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding.
    3. Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice.
      Title: Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice.
    4. FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
      Title: FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
    5. SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway.
      Title: SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway.
    6. Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis.
      Title: Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis.
    7. Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1-mediated deSUMOylation of SIRT3.
      Title: Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1-mediated deSUMOylation of SIRT3.
    8. SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.
      Title: SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.
    9. SENP1 Protects Against Pressure Overload-Induced Cardiac Remodeling and Dysfunction Via Inhibiting STAT3 Signaling.
      Title: SENP1 Protects Against Pressure Overload-Induced Cardiac Remodeling and Dysfunction Via Inhibiting STAT3 Signaling.
    10. SENP1 protects cisplatin-induced AKI by attenuating apoptosis through regulation of HIF-1alpha.
      Title: SENP1 protects cisplatin-induced AKI by attenuating apoptosis through regulation of HIF-1α.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27975

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deSUMOylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deSUMOylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deSUMOylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein desumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein desumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein desumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein desumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of definitive erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sentrin-specific protease 1
    Names
    SUMO-1 protease 2
    SUMO1/sentrin specific protease 1
    sentrin/SUMO-specific protease SENP1
    NP_001366502.1
    NP_659100.1
    XP_006520943.1
    XP_006520945.1
    XP_006520946.1
    XP_006520947.1
    XP_030104385.1
    XP_030104386.1
    XP_036015277.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379573.1 → NP_001366502.1  sentrin-specific protease 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC113444
      Conserved Domains (2) summary
      PRK04863
      Location:381 → 475
      mukB; chromosome partition protein MukB
      cl23802
      Location:448 → 670
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. NM_144851.5 → NP_659100.1  sentrin-specific protease 1 isoform 2

      See identical proteins and their annotated locations for NP_659100.1

      Status: VALIDATED

      Source sequence(s)
      AK009838, AK028565, AK054521, AW490919, BF453574, CX203962
      Consensus CDS
      CCDS49717.1
      UniProtKB/Swiss-Prot
      P59110, Q8BTV5, Q8BZF1
      Related
      ENSMUSP00000046598.9, ENSMUST00000044189.16
      Conserved Domains (1) summary
      cl23802
      Location:416 → 638
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      97936625..97991625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520882.5 → XP_006520945.1  sentrin-specific protease 1 isoform X2

      UniProtKB/TrEMBL
      M0QWX4
      Related
      ENSMUSP00000138056.2, ENSMUST00000180657.2
      Conserved Domains (2) summary
      PRK04863
      Location:375 → 469
      mukB; chromosome partition protein MukB
      cl23802
      Location:442 → 664
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. XM_006520884.5 → XP_006520947.1  sentrin-specific protease 1 isoform X4

      Conserved Domains (1) summary
      COG5160
      Location:259 → 498
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    3. XM_006520883.3 → XP_006520946.1  sentrin-specific protease 1 isoform X3

      Conserved Domains (2) summary
      COG5160
      Location:285 → 524
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      PRK04863
      Location:233 → 327
      mukB; chromosome partition protein MukB

    4. XM_006520880.3 → XP_006520943.1  sentrin-specific protease 1 isoform X1

      Conserved Domains (2) summary
      PRK04863
      Location:407 → 501
      mukB; chromosome partition protein MukB
      cl23802
      Location:474 → 696
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    5. XM_030248526.1 → XP_030104386.1  sentrin-specific protease 1 isoform X4

      Conserved Domains (1) summary
      COG5160
      Location:259 → 498
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    6. XM_030248525.1 → XP_030104385.1  sentrin-specific protease 1 isoform X3

      Conserved Domains (2) summary
      COG5160
      Location:285 → 524
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      PRK04863
      Location:233 → 327
      mukB; chromosome partition protein MukB

    7. XM_036159384.1 → XP_036015277.1  sentrin-specific protease 1 isoform X4

      Conserved Domains (1) summary
      COG5160
      Location:259 → 498
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59110.1 GenPept UniProtKB/Swiss-Prot:P59110

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