Wbp4 WW domain binding protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wbp4provided by MGI
Official Full Name: WW domain binding protein 4provided by MGI
Primary source: MGI:MGI:109568
See related: Ensembl:ENSMUSG00000022023 AllianceGenome:MGI:109568
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FBP21
Summary: Predicted to enable RNA binding activity and proline-rich region binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome. Predicted to act upstream of or within mRNA processing. Part of spliceosomal complex. Is expressed in several structures, including early conceptus and genitourinary system. Orthologous to human WBP4 (WW domain binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 9.8), CNS E18 (RPKM 7.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 42.66 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (79697377..79718708, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (79459937..79481268, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha2077 (e-PCR)
- UniSTS:515481

BB101031 (e-PCR)
- UniSTS:186013

AF071184 (e-PCR)
- UniSTS:186014

AW545037 (e-PCR)
- UniSTS:180708

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA cis splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of U2-type precatalytic spliceosome	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of precatalytic spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WW domain-binding protein 4

Names: WBP-4; WW domain-containing-binding protein 4; formin binding protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018765.3 → NP_061235.2 WW domain-binding protein 4

See identical proteins and their annotated locations for NP_061235.2

Status: PROVISIONAL

Source sequence(s)

AC151994

Consensus CDS

CCDS27300.1

UniProtKB/Swiss-Prot

Q3TUU8, Q61048, Q8K1Z9, Q9CS45

UniProtKB/TrEMBL

Q3TWW5

Related

ENSMUSP00000022601.6, ENSMUST00000022601.7

Conserved Domains (2) summary

COG5104
Location:129 → 195

PRP40; Splicing factor [RNA processing and modification]

pfam06220
Location:8 → 44

zf-U1; U1 zinc finger