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    Mpped1 metallophosphoesterase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 223726, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Mpped1provided by MGI
    Official Full Name
    metallophosphoesterase domain containing 1provided by MGI
    Primary source
    MGI:MGI:106316
    See related
    Ensembl:ENSMUSG00000041708 AllianceGenome:MGI:106316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6230403M19; D15Bwg0669e
    Summary
    Predicted to enable hydrolase activity. Is expressed in brain and tooth. Orthologous to human MPPED1 (metallophosphoesterase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 22.0), cortex adult (RPKM 14.1) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E1; 15 39.44 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83656256..83742688)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83779472..83858487)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene signal peptide, CUB domain, EGF-like 1 Neighboring gene predicted gene, 52183 Neighboring gene predicted gene, 33324 Neighboring gene STARR-seq mESC enhancer starr_39343 Neighboring gene predicted gene, 52172 Neighboring gene predicted gene, 41370 Neighboring gene STARR-seq mESC enhancer starr_39344 Neighboring gene predicted gene, 41372 Neighboring gene EF-hand calcium binding domain 6 Neighboring gene ribosomal protein L31, pseudogene 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression analysis of an evolutionarily conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon. Chen CM, et al. Dev Dyn, 2010 Jun. PMID 20503375
    2. NOVA2 regulates neural circRNA biogenesis. Knupp D, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34157123, Free PMC Article
    3. Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Telley L, et al. Science, 2019 May 10. PMID 31073041
    4. Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. Boyle MP, et al. J Comp Neurol, 2011 Aug 1. PMID 21491433
    5. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    metallophosphoesterase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359131.1 → NP_001346060.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL513354, AL591964
      Consensus CDS
      CCDS37164.1
      UniProtKB/Swiss-Prot
      A6PW09, Q3TMS4, Q3TYC7, Q91ZG2
      Related
      ENSMUSP00000105096.2, ENSMUST00000109470.8
      Conserved Domains (1) summary
      cd07379
      Location:91 → 303
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

    2. NM_001359132.1 → NP_001346061.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL513354, AL591964
      Consensus CDS
      CCDS37164.1
      UniProtKB/Swiss-Prot
      A6PW09, Q3TMS4, Q3TYC7, Q91ZG2
      Conserved Domains (1) summary
      cd07379
      Location:91 → 303
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

    3. NM_001416023.1 → NP_001402952.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL513354, AL591964
      UniProtKB/Swiss-Prot
      A6PW09, Q3TMS4, Q3TYC7, Q91ZG2

    4. NM_001416024.1 → NP_001402953.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL513354, AL591964
      UniProtKB/Swiss-Prot
      A6PW09, Q3TMS4, Q3TYC7, Q91ZG2

    5. NM_001416025.1 → NP_001402954.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL513354, AL591964
      UniProtKB/Swiss-Prot
      A6PW09, Q3TMS4, Q3TYC7, Q91ZG2

    6. NM_001416026.1 → NP_001402955.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL513354, AL591964
      UniProtKB/Swiss-Prot
      A6PW09, Q3TMS4, Q3TYC7, Q91ZG2

    7. NM_001416027.1 → NP_001402956.1  metallophosphoesterase domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL513354, AL591964
      UniProtKB/TrEMBL
      E9Q0C0

    8. NM_001416028.1 → NP_001402957.1  metallophosphoesterase domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL513354, AL591964
      UniProtKB/TrEMBL
      E9Q0C0
      Related
      ENSMUSP00000126242.2, ENSMUST00000163723.8

    9. NM_172610.4 → NP_766198.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_766198.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL513354, AL591964
      Consensus CDS
      CCDS37164.1
      UniProtKB/Swiss-Prot
      A6PW09, Q3TMS4, Q3TYC7, Q91ZG2
      Related
      ENSMUSP00000041981.6, ENSMUST00000046168.12
      Conserved Domains (1) summary
      cd07379
      Location:91 → 303
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

    RNA

    1. NR_152841.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL513354, AL591964

    2. NR_183244.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL513354, AL591964
      Related
      ENSMUST00000123387.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      83656256..83742688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520817.5 → XP_006520880.1  metallophosphoesterase domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006520880.1

      UniProtKB/Swiss-Prot
      A6PW09, Q3TMS4, Q3TYC7, Q91ZG2
      Conserved Domains (1) summary
      cd07379
      Location:91 → 303
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZG2.1 GenPept UniProtKB/Swiss-Prot:Q91ZG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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