U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Trpv2 transient receptor potential cation channel, subfamily V, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 22368, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Trpv2provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily V, member 2provided by MGI
    Primary source
    MGI:MGI:1341836
    See related
    Ensembl:ENSMUSG00000018507 AllianceGenome:MGI:1341836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GRC; Vrl1; VRL-1; OTRPC2
    Summary
    Enables calcium channel activity. Involved in positive regulation of axon extension; positive regulation of calcium ion import; and positive regulation of cold-induced thermogenesis. Located in cell body; cell surface; and growth cone. Is expressed in central nervous system; dorsal root ganglion; sensory organ; and testis. Orthologous to human TRPV2 (transient receptor potential cation channel subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 24.2), placenta adult (RPKM 13.8) and 21 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    11 B2; 11 38.48 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62465312..62491131)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62574486..62600305)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12279 Neighboring gene STARR-seq mESC enhancer starr_29713 Neighboring gene ubiquitin B Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:62387853-62388036 Neighboring gene RIKEN cDNA 2410006H16 gene Neighboring gene STARR-positive B cell enhancer ABC_E9364 Neighboring gene small nucleolar RNA, C/D box 49B Neighboring gene small nucleolar RNA, C/D box 49A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus. Liu G, et al. Biochem Biophys Res Commun, 2022 Sep 10. PMID 35785569
    2. Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models. Iwata Y, et al. Lab Invest, 2020 Feb. PMID 31896817
    3. Nitric oxide upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane. Maksoud MJE, et al. Glia, 2019 Dec. PMID 31453646
    4. Reduced transient receptor potential vanilloid 2 expression in alveolar macrophages causes COPD in mice through impaired phagocytic activity. Masubuchi H, et al. BMC Pulm Med, 2019 Mar 26. PMID 30914062, Free PMC Article
    5. TRPV2 channels mediate insulin secretion induced by cell swelling in mouse pancreatic β-cells. Sawatani T, et al. Am J Physiol Cell Physiol, 2019 Mar 1. PMID 30649920

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ion channel TRPV2 is critical in enhancing B cell activation and function.
      Title: Ion channel TRPV2 is critical in enhancing B cell activation and function.
    2. High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling.
      Title: High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling.
    3. Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta.
      Title: Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta.
    4. Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region.
      Title: Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region.
    5. The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca[2+] -LRMDA Axis in Myeloid Cells.
      Title: The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca(2+) -LRMDA Axis in Myeloid Cells.
    6. Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus.
      Title: Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus.
    7. Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.
      Title: Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.
    8. Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.
      Title: Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.
    9. TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions.
      Title: TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions.
    10. Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis.
      Title: Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis.
    Submit: New GeneRIF Correction See all GeneRIFs (56)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (4) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to temperature stimulus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    transient receptor potential cation channel subfamily V member 2
    Names
    growth factor regulated channel
    growth factor-regulated calcium channel
    osm-9-like TRP channel 2
    vanilloid receptor-like protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382489.1 → NP_001369418.1  transient receptor potential cation channel subfamily V member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596181
      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66 → 705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

    2. NM_001382490.1 → NP_001369419.1  transient receptor potential cation channel subfamily V member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596181
      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66 → 705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

    3. NM_001382491.1 → NP_001369420.1  transient receptor potential cation channel subfamily V member 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596181
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cl40437
      Location:66 → 658
      TRPV; Transient Receptor Potential channel, Vanilloid subfamily (TRPV)

    4. NM_001382492.1 → NP_001369421.1  transient receptor potential cation channel subfamily V member 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL596181
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cl40437
      Location:66 → 647
      TRPV; Transient Receptor Potential channel, Vanilloid subfamily (TRPV)

    5. NM_011706.2 → NP_035836.2  transient receptor potential cation channel subfamily V member 2 isoform 1

      See identical proteins and their annotated locations for NP_035836.2

      Status: VALIDATED

      Source sequence(s)
      AK008689, BB631765, BY648241
      Consensus CDS
      CCDS24827.1
      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Related
      ENSMUSP00000018651.8, ENSMUST00000018651.14
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66 → 705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62465312..62491131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156630.1 → XP_036012523.1  transient receptor potential cation channel subfamily V member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Related
      ENSMUSP00000099703.2, ENSMUST00000102643.2
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66 → 705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTR1.2 GenPept UniProtKB/Swiss-Prot:Q9WTR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous