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    Zfp7 zinc finger protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 223669, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Zfp7provided by MGI
    Official Full Name
    zinc finger protein 7provided by MGI
    Primary source
    MGI:MGI:99208
    See related
    Ensembl:ENSMUSG00000033669 AllianceGenome:MGI:99208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KRAB7; Zfp-7; Zfp65; Zfp80; KRAB20; Krox-2; mszf73-2; Zfp86-rs1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; ganglia; metanephros; nasal cavity epithelium; and ureter. Orthologous to human ZNF7 (zinc finger protein 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.7), bladder adult (RPKM 4.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D3; 15 36.28 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76763440..76786089)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76879253..76892395)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 39 Neighboring gene STARR-positive B cell enhancer ABC_E8939 Neighboring gene STARR-seq mESC enhancer starr_39062 Neighboring gene predicted gene, 41350 Neighboring gene zinc finger protein 251 Neighboring gene STARR-positive B cell enhancer ABC_E11593 Neighboring gene STARR-positive B cell enhancer ABC_E2442 Neighboring gene STARR-positive B cell enhancer ABC_E5492 Neighboring gene COMM domain containing 5 Neighboring gene ribosomal protein L8 Neighboring gene zinc finger protein 647

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a mouse multigene family that encodes zinc finger structures. Chavrier P, et al. Mol Cell Biol, 1988 Mar. PMID 2452975, Free PMC Article
    2. Myelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve. Taïb S, et al. Elife, 2022 Jan 12. PMID 35019839, Free PMC Article
    3. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    4. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    5. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6397

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 7
    Names
    zinc finger protein 86, related sequence 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358816.2 → NP_001345745.1  zinc finger protein 7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC157554
      Consensus CDS
      CCDS37124.1
      UniProtKB/TrEMBL
      Q3TFZ4, Q921K6
      Related
      ENSMUSP00000155599.2, ENSMUST00000230106.2
      Conserved Domains (3) summary
      smart00349
      Location:4 → 65
      KRAB; krueppel associated box
      COG5048
      Location:246 → 668
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001358817.3 → NP_001345746.1  zinc finger protein 7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC157554
      UniProtKB/TrEMBL
      Q921K6
      Conserved Domains (3) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:245 → 667
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001358818.3 → NP_001345747.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC157554
      Conserved Domains (2) summary
      COG5048
      Location:103 → 525
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:299 → 319
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001416163.1 → NP_001403092.1  zinc finger protein 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157554

    5. NM_001416164.1 → NP_001403093.1  zinc finger protein 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157554

    6. NM_001416166.1 → NP_001403095.1  zinc finger protein 7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC157554

    7. NM_001416167.1 → NP_001403096.1  zinc finger protein 7 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC157554

    8. NM_001416168.1 → NP_001403097.1  zinc finger protein 7 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC157554

    9. NM_001416169.1 → NP_001403098.1  zinc finger protein 7 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC157554

    10. NM_001416170.1 → NP_001403099.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    11. NM_001416171.1 → NP_001403100.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    12. NM_001416172.1 → NP_001403101.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    13. NM_001416173.1 → NP_001403102.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    14. NM_001416174.1 → NP_001403103.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    15. NM_001416175.1 → NP_001403104.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    16. NM_001416176.1 → NP_001403105.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    17. NM_001416177.1 → NP_001403106.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    18. NM_001416178.1 → NP_001403107.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    19. NM_001416179.1 → NP_001403108.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    20. NM_001416180.1 → NP_001403109.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    21. NM_001416181.1 → NP_001403110.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    22. NM_001416182.1 → NP_001403111.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    23. NM_001416183.1 → NP_001403112.1  zinc finger protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157554

    24. NM_001416184.1 → NP_001403113.1  zinc finger protein 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157554

    25. NM_145916.5 → NP_666021.2  zinc finger protein 7 isoform 1

      See identical proteins and their annotated locations for NP_666021.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC157554
      Consensus CDS
      CCDS37124.1
      UniProtKB/TrEMBL
      Q3TFZ4, Q921K6
      Related
      ENSMUSP00000023179.6, ENSMUST00000023179.7
      Conserved Domains (3) summary
      smart00349
      Location:4 → 65
      KRAB; krueppel associated box
      COG5048
      Location:246 → 668
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_183485.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157554

    2. NR_183486.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157554

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76763440..76786089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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