Vpreb1a V-set pre-B cell surrogate light chain 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vpreb1aprovided by MGI
Official Full Name: V-set pre-B cell surrogate light chain 1Aprovided by MGI
Primary source: MGI:MGI:98936
See related: Ensembl:ENSMUSG00000059305 AllianceGenome:MGI:98936
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD179a; Vpreb1; Vpreb-1
Summary: Enables signaling receptor activity. Acts upstream of or within several processes, including B cell proliferation; homeostasis of number of cells; and regulation of cell size. Located in external side of plasma membrane. Is expressed in bone marrow; liver; and spleen. Orthologous to human VPREB1 (V-set pre-B cell surrogate light chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 13.3), thymus adult (RPKM 2.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 10.46 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (16686265..16687119, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (16868401..16869255, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show no autoantibody production was detectable in surrogate light chain (SLC) components VpreB/CD179a and lambda5/CD179b transgenic mice.
Title: Surrogate light chain expression beyond the pre-B cell stage promotes tolerance in a dose-dependent fashion.
VpreB probes the fitness of newly generated VH domains of IgH chains for later pairing with IgL chains, and its non-Ig part fixes the preBCRs on the surface.
Title: The non-Ig parts of the VpreB and λ5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor.
The epigenetic profile of immunoglobulin light chain (IgL) genes is strongly influenced by pre-B cell receptor signaling and by the differentiative stage of the progenitor lymphocytes.
Title: The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling.
Multiple receptor-dependent mechanisms operating at all stages of B cell development limit the contribution of B cells with Dmu heavy chain alleles to the repertoire.
Title: Multiple levels of selection responsive to immunoglobulin light chain and heavy chain structures impede the development of Dmu-expressing B cells.
Mice triply deficient for VpreB1 show B cell developmental defects but functional allelic exclusion of the IgH locus.
Title: VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus.
To identify the sequences that regulate lambda5 and VpreB1 expression during B cell development, the DNaseI hypersensitive sites in the lambda5-VpreB1 functional domain were mapped.
Title: Mapping and functional analysis of regulatory sequences in the mouse lambda5-VpreB1 domain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV103084 (e-PCR)
- UniSTS:209173

NoName (e-PCR)
- UniSTS:492603

X05556 (e-PCR)
- UniSTS:125789

Vpreb1 (e-PCR), detects polymorphism
- UniSTS:259191

Vpreb1 (e-PCR), detects polymorphism
- UniSTS:144761

Vpreb1 (e-PCR), detects polymorphism
- UniSTS:256455

X05556 (e-PCR)
- UniSTS:163563

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within B cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	IPI Inferred from Physical Interaction more info	PubMed
involved_in immunoglobulin production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immunoglobulin production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell size	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: immunoglobulin iota chain

Names: pre-B lymphocyte gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.